Motif ID: STAT6
Z-value: 0.740
Transcription factors associated with STAT6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| STAT6 | ENSG00000166888.6 | STAT6 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT6 | hg19_v2_chr12_-_57505121_57505216 | 0.26 | 2.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.4 | 1.2 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
| 0.3 | 1.0 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.3 | 1.2 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
| 0.2 | 1.9 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.2 | 1.5 | GO:0030578 | PML body organization(GO:0030578) |
| 0.2 | 0.8 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.2 | 1.9 | GO:0045542 | positive regulation of cholesterol biosynthetic process(GO:0045542) |
| 0.1 | 0.7 | GO:0008204 | ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204) |
| 0.1 | 0.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 0.4 | GO:0090425 | hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.1 | 1.1 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.1 | 1.1 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.1 | 2.1 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 1.0 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.3 | GO:0016094 | polyprenol biosynthetic process(GO:0016094) |
| 0.1 | 0.3 | GO:0015772 | disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772) |
| 0.1 | 6.5 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
| 0.1 | 0.3 | GO:0032679 | TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759) |
| 0.1 | 0.4 | GO:1902162 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.1 | 0.7 | GO:1903243 | negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243) |
| 0.1 | 0.4 | GO:0007619 | courtship behavior(GO:0007619) |
| 0.1 | 1.0 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 0.9 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.1 | 0.4 | GO:0070945 | neutrophil mediated killing of gram-negative bacterium(GO:0070945) |
| 0.1 | 0.6 | GO:0048733 | sebaceous gland development(GO:0048733) |
| 0.1 | 0.2 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 0.2 | GO:0060380 | regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) |
| 0.1 | 0.6 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 0.5 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.0 | 0.2 | GO:0030070 | insulin processing(GO:0030070) |
| 0.0 | 0.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.0 | 0.3 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.0 | 0.3 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.0 | 0.4 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.0 | 0.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.0 | 0.2 | GO:0019566 | arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373) |
| 0.0 | 0.2 | GO:0038169 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.0 | 0.6 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.0 | 0.3 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 0.6 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.0 | 1.1 | GO:0006833 | water transport(GO:0006833) |
| 0.0 | 0.8 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.0 | 0.2 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 0.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.9 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.2 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.0 | 0.4 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.1 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.0 | 0.5 | GO:2000479 | regulation of cAMP-dependent protein kinase activity(GO:2000479) |
| 0.0 | 0.2 | GO:0030202 | heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 0.0 | 0.1 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.0 | 0.0 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.0 | 0.3 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.0 | 0.1 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 0.0 | 1.0 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.2 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.0 | 0.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.2 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.0 | 1.0 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 0.8 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 0.2 | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 0.9 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 0.2 | GO:1902358 | sulfate transmembrane transport(GO:1902358) |
| 0.0 | 0.4 | GO:2001240 | negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240) |
| 0.0 | 0.2 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.2 | 0.9 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.1 | 0.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.0 | 0.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 2.1 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.3 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.1 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.0 | 1.9 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.1 | GO:0097679 | other organism cytoplasm(GO:0097679) |
| 0.0 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.8 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.2 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 8.2 | GO:0005925 | focal adhesion(GO:0005925) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.4 | 1.9 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.4 | 1.8 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.3 | 0.9 | GO:0047223 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223) |
| 0.2 | 0.9 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.2 | 2.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 0.7 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.2 | 1.0 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 0.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.1 | 1.0 | GO:0043426 | MRF binding(GO:0043426) |
| 0.1 | 0.3 | GO:0002094 | polyprenyltransferase activity(GO:0002094) |
| 0.1 | 0.6 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.1 | 0.3 | GO:0008515 | sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.1 | 0.4 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.1 | 1.1 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 0.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 0.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.6 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 0.4 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.4 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.1 | GO:0032093 | SAM domain binding(GO:0032093) |
| 0.0 | 0.2 | GO:0046556 | alpha-L-arabinofuranosidase activity(GO:0046556) |
| 0.0 | 1.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.2 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.0 | 0.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.5 | GO:0031628 | opioid receptor binding(GO:0031628) |
| 0.0 | 1.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.2 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 7.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 1.2 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.2 | GO:0008048 | calcium sensitive guanylate cyclase activator activity(GO:0008048) |
| 0.0 | 0.2 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.0 | 1.0 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.3 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.0 | 1.0 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 1.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 0.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.0 | 1.2 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.6 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 0.2 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 0.2 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 0.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.0 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.1 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 3.6 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.8 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.4 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.2 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.9 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 1.8 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.9 | REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.1 | 1.0 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 0.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.6 | REACTOME_OPSINS | Genes involved in Opsins |
| 0.0 | 2.1 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 2.1 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.7 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 1.5 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.5 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.7 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.2 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.5 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.3 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
