Motif ID: T

Z-value: 0.566


Transcription factors associated with T:

Gene SymbolEntrez IDGene Name
T ENSG00000164458.5 T

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thg19_v2_chr6_-_166582107_1665821880.154.7e-01Click!


Activity profile for motif T.

activity profile for motif T


Sorted Z-values histogram for motif T

Sorted Z-values for motif T



Network of associatons between targets according to the STRING database.



First level regulatory network of T

PNG image of the network

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Top targets:


Showing 1 to 20 of 193 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_153029980 1.750 ENST00000392653.2
 SPRR2A
small proline-rich protein 2A
chr14_+_75746781 1.542 ENST00000555347.1
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr10_+_94833642 1.372 ENST00000224356.4
ENST00000394139.1
 CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

chr12_-_52845910 1.323 ENST00000252252.3
 KRT6B
keratin 6B
chr1_-_153066998 1.230 ENST00000368750.3
 SPRR2E
small proline-rich protein 2E
chr21_+_30502806 1.189 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL

MAP3K7 C-terminal like

chr9_+_36572851 0.981 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
 MELK







maternal embryonic leucine zipper kinase







chr2_-_216003127 0.864 ENST00000412081.1
ENST00000272895.7
 ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12

chr12_+_22778291 0.843 ENST00000545979.1
 ETNK1
ethanolamine kinase 1
chr12_-_6961050 0.817 ENST00000538862.2
 CDCA3
cell division cycle associated 3
chr7_+_134576317 0.771 ENST00000424922.1
ENST00000495522.1
 CALD1

caldesmon 1

chr12_-_6960407 0.751 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
 CDCA3



cell division cycle associated 3



chr19_-_44174330 0.726 ENST00000340093.3
 PLAUR
plasminogen activator, urokinase receptor
chr12_-_69326940 0.621 ENST00000549781.1
ENST00000548262.1
ENST00000551568.1
ENST00000548954.1
 CPM



carboxypeptidase M



chr19_-_44174305 0.608 ENST00000601723.1
ENST00000339082.3
 PLAUR

plasminogen activator, urokinase receptor

chr2_-_85636928 0.607 ENST00000449030.1
 CAPG
capping protein (actin filament), gelsolin-like
chr4_-_73434498 0.599 ENST00000286657.4
 ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr9_+_40028620 0.597 ENST00000426179.1
 AL353791.1
AL353791.1
chr1_-_24126023 0.593 ENST00000429356.1
 GALE
UDP-galactose-4-epimerase
chr20_+_44637526 0.587 ENST00000372330.3
 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0018149 peptide cross-linking(GO:0018149)
0.2 1.5 GO:0001661 conditioned taste aversion(GO:0001661)
0.3 1.4 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0 1.4 GO:0006491 N-glycan processing(GO:0006491)
0.3 1.3 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.0 1.3 GO:0007398 ectoderm development(GO:0007398)
0.0 1.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.1 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 1.0 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 1.0 GO:0019388 galactose catabolic process(GO:0019388)
0.0 1.0 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.2 0.9 GO:0035627 ceramide transport(GO:0035627)
0.0 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.7 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) protein K29-linked ubiquitination(GO:0035519)
0.1 0.7 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 0.6 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.6 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1 0.6 GO:0035803 egg coat formation(GO:0035803)
0.0 0.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.5 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.8 GO:0045095 keratin filament(GO:0045095)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 1.5 GO:0035976 AP1 complex(GO:0035976)
0.1 1.3 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.0 GO:0033010 paranodal junction(GO:0033010)
0.1 0.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.8 GO:0030478 actin cap(GO:0030478)
0.0 0.6 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.3 GO:0043259 laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.1 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 1.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.4 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 1.3 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.1 1.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 1.0 GO:0003974 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.2 0.9 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.1 0.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 0.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.7 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.0 0.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.6 GO:0032190 acrosin binding(GO:0032190)
0.0 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 0.5 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.5 GO:0001972 retinoic acid binding(GO:0001972)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 1.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.4 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.4 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.4 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.3 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.9 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.6 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.3 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR