Motif ID: TAF1

Z-value: 2.179


Transcription factors associated with TAF1:

Gene SymbolEntrez IDGene Name
TAF1 ENSG00000147133.11 TAF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TAF1hg19_v2_chrX_+_70586140_705862180.481.8e-02Click!


Activity profile for motif TAF1.

activity profile for motif TAF1


Sorted Z-values histogram for motif TAF1

Sorted Z-values for motif TAF1



Network of associatons between targets according to the STRING database.



First level regulatory network of TAF1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_197676740 13.599 ENST00000452735.1
ENST00000453254.1
ENST00000455191.1
 IQCG


IQ motif containing G


chr11_-_62477041 10.211 ENST00000433053.1
 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_62476965 10.109 ENST00000405837.1
ENST00000531524.1
 BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr3_-_197686847 8.759 ENST00000265239.6
 IQCG
IQ motif containing G
chr1_+_245133656 7.624 ENST00000366521.3
 EFCAB2
EF-hand calcium binding domain 2
chr11_+_101918153 6.561 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
 C11orf70


chromosome 11 open reading frame 70


chr19_-_11545920 6.395 ENST00000356392.4
ENST00000591179.1
 CCDC151

coiled-coil domain containing 151

chr17_+_45908974 5.691 ENST00000269025.4
 LRRC46
leucine rich repeat containing 46
chr12_+_49297899 5.050 ENST00000552942.1
ENST00000320516.4
 CCDC65

coiled-coil domain containing 65

chr1_+_38022572 4.917 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr18_-_47813940 4.478 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
 CXXC1


CXXC finger protein 1


chr1_+_38022513 4.345 ENST00000296218.7
 DNALI1
dynein, axonemal, light intermediate chain 1
chr4_+_15480828 4.319 ENST00000389652.5
 CC2D2A
coiled-coil and C2 domain containing 2A
chr5_-_139944196 4.114 ENST00000357560.4
 APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr13_+_35516390 4.014 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr11_-_34937858 3.887 ENST00000278359.5
 APIP
APAF1 interacting protein
chr17_+_7487146 3.863 ENST00000396501.4
ENST00000584378.1
ENST00000423172.2
ENST00000579445.1
ENST00000585217.1
ENST00000581380.1
 MPDU1





mannose-P-dolichol utilization defect 1





chr5_-_139943830 3.679 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
 APBB3





amyloid beta (A4) precursor protein-binding, family B, member 3





chr6_-_43478239 3.611 ENST00000372441.1
 LRRC73
leucine rich repeat containing 73
chr4_-_16228083 3.576 ENST00000399920.3
 TAPT1
transmembrane anterior posterior transformation 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 461 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 23.5 GO:0007288 sperm axoneme assembly(GO:0007288)
0.7 19.8 GO:0034389 lipid particle organization(GO:0034389)
0.5 11.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 10.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 8.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.2 7.0 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.6 6.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) pyroptosis(GO:0070269)
0.3 6.4 GO:0036158 outer dynein arm assembly(GO:0036158)
1.3 6.3 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.2 6.0 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.3 5.5 GO:1903012 positive regulation of bone development(GO:1903012)
0.2 5.3 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.3 5.2 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
1.3 5.2 GO:0019046 release from viral latency(GO:0019046)
0.3 5.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.1 4.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 4.6 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 4.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.1 4.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.6 4.3 GO:1904491 protein localization to ciliary transition zone(GO:1904491)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 23.9 GO:0002177 manchette(GO:0002177)
0.1 23.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.7 13.4 GO:0036038 MKS complex(GO:0036038)
0.1 10.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.2 10.5 GO:0030286 dynein complex(GO:0030286)
0.5 10.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.2 8.9 GO:0016592 mediator complex(GO:0016592)
0.1 8.1 GO:0036064 ciliary basal body(GO:0036064)
1.1 7.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 6.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 6.5 GO:0000139 Golgi membrane(GO:0000139)
0.1 6.4 GO:0015030 Cajal body(GO:0015030)
0.1 6.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4 5.6 GO:0034464 BBSome(GO:0034464)
0.3 5.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 4.4 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.2 4.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 4.0 GO:0071141 SMAD protein complex(GO:0071141)
0.2 3.8 GO:0000242 pericentriolar material(GO:0000242)
0.2 3.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 290 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 24.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.2 15.1 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.5 11.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 8.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.5 8.0 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.2 6.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 6.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 6.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.2 6.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 6.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 5.5 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.1 5.5 GO:0101005 ubiquitinyl hydrolase activity(GO:0101005)
0.8 5.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.1 5.1 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 5.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 4.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 4.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 4.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
1.5 4.5 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 4.5 GO:0002039 p53 binding(GO:0002039)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 7.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 5.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 5.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 PID_INSULIN_PATHWAY Insulin Pathway
0.0 1.5 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.4 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.3 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.3 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 1.1 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.0 1.1 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.1 PID_CD40_PATHWAY CD40/CD40L signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 9.0 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 6.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 6.9 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.2 6.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 6.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 5.8 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 5.7 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 4.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.1 4.3 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 4.1 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 4.0 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.5 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 3.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 3.2 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 3.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 2.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.8 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII