Motif ID: TAL1

Z-value: 1.079


Transcription factors associated with TAL1:

Gene SymbolEntrez IDGene Name
TAL1 ENSG00000162367.7 TAL1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TAL1hg19_v2_chr1_-_47697387_47697457-0.125.7e-01Click!


Activity profile for motif TAL1.

activity profile for motif TAL1


Sorted Z-values histogram for motif TAL1

Sorted Z-values for motif TAL1



Network of associatons between targets according to the STRING database.



First level regulatory network of TAL1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_24911195 4.028 ENST00000259698.4
 FAM65B
family with sequence similarity 65, member B
chr4_-_16085340 3.555 ENST00000508167.1
 PROM1
prominin 1
chr4_-_16085314 3.151 ENST00000510224.1
 PROM1
prominin 1
chr1_-_47407097 2.928 ENST00000457840.2
 CYP4A11
cytochrome P450, family 4, subfamily A, polypeptide 11
chr17_-_4689649 2.632 ENST00000441199.2
ENST00000416307.2
 VMO1

vitelline membrane outer layer 1 homolog (chicken)

chr4_-_16077741 2.529 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
 PROM1


prominin 1


chr4_+_75858318 2.381 ENST00000307428.7
 PARM1
prostate androgen-regulated mucin-like protein 1
chr17_-_39280419 2.078 ENST00000394014.1
 KRTAP4-12
keratin associated protein 4-12
chr16_+_84209539 2.052 ENST00000569735.1
 DNAAF1
dynein, axonemal, assembly factor 1
chr9_+_127615733 1.968 ENST00000373574.1
 WDR38
WD repeat domain 38
chr14_-_107078851 1.870 ENST00000390628.2
 IGHV1-58
immunoglobulin heavy variable 1-58
chr1_+_47264711 1.801 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr15_-_56757329 1.740 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr19_-_55677920 1.606 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr16_-_67427389 1.594 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
 TPPP3


tubulin polymerization-promoting protein family member 3


chr1_+_38022572 1.570 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr3_-_169530452 1.570 ENST00000446859.1
 LRRC34
leucine rich repeat containing 34
chr19_-_41388657 1.553 ENST00000301146.4
ENST00000291764.3
 CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr13_-_39564993 1.537 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3
chr7_-_99569468 1.523 ENST00000419575.1
 AZGP1
alpha-2-glycoprotein 1, zinc-binding

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 889 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 9.3 GO:2000768 positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 8.9 GO:0001895 retina homeostasis(GO:0001895)
0.2 5.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 4.0 GO:0003341 cilium movement(GO:0003341)
0.2 3.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 3.6 GO:0035082 axoneme assembly(GO:0035082)
0.3 3.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 3.3 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 3.2 GO:0060972 left/right pattern formation(GO:0060972)
0.2 3.1 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 3.0 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.7 2.9 GO:0003095 pressure natriuresis(GO:0003095)
0.3 2.9 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.7 2.8 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.3 2.8 GO:0001554 luteolysis(GO:0001554)
0.1 2.7 GO:0009068 aspartate family amino acid catabolic process(GO:0009068)
0.0 2.7 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.5 2.6 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 2.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 2.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 263 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.8 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.4 8.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.3 5.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 4.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 4.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 3.4 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.7 GO:0001650 fibrillar center(GO:0001650)
0.2 2.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 2.4 GO:0036064 ciliary basal body(GO:0036064)
0.2 2.3 GO:0097433 dense body(GO:0097433)
0.1 2.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 2.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.0 GO:0036038 MKS complex(GO:0036038)
0.2 1.9 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.6 1.7 GO:0001534 radial spoke(GO:0001534)
0.2 1.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 1.6 GO:0030286 dynein complex(GO:0030286)
0.0 1.6 GO:0070469 respiratory chain(GO:0070469)
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 509 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0042805 actinin binding(GO:0042805)
0.3 4.9 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.6 4.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 4.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 4.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 4.2 GO:0008009 chemokine activity(GO:0008009)
0.9 3.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 3.1 GO:0032395 MHC class II receptor activity(GO:0032395)
0.7 2.9 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.4 2.9 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.5 2.8 GO:0004771 sterol esterase activity(GO:0004771)
0.1 2.8 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 2.8 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity(GO:0004114)
0.1 2.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.7 GO:0051082 unfolded protein binding(GO:0051082)
0.4 2.6 GO:0004522 ribonuclease A activity(GO:0004522)
0.2 2.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 2.5 GO:0019905 syntaxin binding(GO:0019905)
0.1 2.4 GO:0017075 syntaxin-1 binding(GO:0017075)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 2.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.7 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 2.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 1.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 5.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 4.0 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 3.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 2.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.6 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 2.3 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 2.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.3 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 2.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.2 2.1 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.9 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.1 1.9 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.9 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.6 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 1.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds