Motif ID: TBP

Z-value: 1.745


Transcription factors associated with TBP:

Gene SymbolEntrez IDGene Name
TBP ENSG00000112592.8 TBP

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBPhg19_v2_chr6_+_170863421_1708634840.242.5e-01Click!


Activity profile for motif TBP.

activity profile for motif TBP


Sorted Z-values histogram for motif TBP

Sorted Z-values for motif TBP



Network of associatons between targets according to the STRING database.



First level regulatory network of TBP

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_23261589 7.366 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
LOXL2



lysyl oxidase-like 2



chr1_-_153044083 6.632 ENST00000341611.2
SPRR2B
small proline-rich protein 2B
chr1_-_153013588 5.798 ENST00000360379.3
SPRR2D
small proline-rich protein 2D
chr15_+_45722727 5.055 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
C15orf48


chromosome 15 open reading frame 48


chr12_-_52845910 5.034 ENST00000252252.3
KRT6B
keratin 6B
chr4_-_57547454 4.779 ENST00000556376.2
HOPX
HOP homeobox
chr4_-_57547870 4.687 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX



HOP homeobox



chr8_-_6735451 4.589 ENST00000297439.3
DEFB1
defensin, beta 1
chr12_+_4385230 4.579 ENST00000536537.1
CCND2
cyclin D2
chr21_-_28217721 4.434 ENST00000284984.3
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr8_-_133097902 4.417 ENST00000262283.5
OC90
Otoconin-90
chr1_+_152881014 4.366 ENST00000368764.3
ENST00000392667.2
IVL

involucrin

chr19_+_6531010 4.265 ENST00000245817.3
TNFSF9
tumor necrosis factor (ligand) superfamily, member 9
chr1_-_205419053 4.134 ENST00000367154.1
LEMD1
LEM domain containing 1
chr6_-_2903514 3.905 ENST00000380698.4
SERPINB9
serpin peptidase inhibitor, clade B (ovalbumin), member 9
chr3_-_111314230 3.682 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr14_+_75745477 3.649 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS




FBJ murine osteosarcoma viral oncogene homolog




chr15_+_81071684 3.546 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
KIAA1199


KIAA1199


chr11_+_43964055 3.270 ENST00000528572.1
C11orf96
chromosome 11 open reading frame 96
chr18_+_34124507 3.225 ENST00000591635.1
FHOD3
formin homology 2 domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 33.2 GO:0070268 cornification(GO:0070268)
0.3 8.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 7.4 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
1.5 7.3 GO:0060356 leucine import(GO:0060356)
0.2 6.8 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 5.3 GO:0006334 nucleosome assembly(GO:0006334)
0.9 5.2 GO:0055064 chloride ion homeostasis(GO:0055064)
1.0 5.1 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.2 4.7 GO:0071481 cellular response to X-ray(GO:0071481)
1.5 4.6 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.5 4.6 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
1.5 4.4 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.3 4.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 4.4 GO:1903963 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
1.1 4.3 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.2 4.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.3 4.1 GO:0002227 innate immune response in mucosa(GO:0002227)
1.3 4.0 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
1.3 3.9 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.1 3.9 GO:0006953 acute-phase response(GO:0006953)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.8 GO:0001533 cornified envelope(GO:0001533)
0.1 16.5 GO:0005882 intermediate filament(GO:0005882)
0.2 11.1 GO:0000786 nucleosome(GO:0000786)
0.1 10.9 GO:0005604 basement membrane(GO:0005604)
0.0 7.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 5.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 5.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
1.5 4.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
1.1 4.6 GO:1990742 microvesicle(GO:1990742)
0.8 4.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 4.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 4.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
1.0 4.0 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.5 3.6 GO:0035976 AP1 complex(GO:0035976)
1.1 3.4 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 3.2 GO:0005865 striated muscle thin filament(GO:0005865)
1.0 3.0 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
1.0 3.0 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 3.0 GO:0001772 immunological synapse(GO:0001772)
0.1 2.8 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 168 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 31.2 GO:0005198 structural molecule activity(GO:0005198)
0.0 9.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 8.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
1.5 7.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.5 7.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 6.9 GO:0003684 damaged DNA binding(GO:0003684)
0.3 5.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 5.1 GO:0017124 SH3 domain binding(GO:0017124)
1.5 4.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.3 4.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 4.6 GO:0003823 antigen binding(GO:0003823)
0.1 4.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 4.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 4.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 3.9 GO:0016918 retinal binding(GO:0016918)
0.1 3.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 3.6 GO:0070412 R-SMAD binding(GO:0070412)
1.1 3.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 3.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
1.0 3.0 GO:0070699 type II activin receptor binding(GO:0070699)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 5.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 5.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 5.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.1 4.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.6 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.3 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 4.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 3.7 PID_ALK1_PATHWAY ALK1 signaling events
0.2 3.6 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.8 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 2.5 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 2.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.2 9.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 5.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.3 5.5 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.3 5.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 5.2 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.3 4.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 4.6 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.1 4.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 4.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 3.9 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.1 3.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 3.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.6 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 2.5 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 2.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions