Motif ID: TBX15_MGA
Z-value: 0.562
Transcription factors associated with TBX15_MGA:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| MGA | ENSG00000174197.12 | MGA |
| TBX15 | ENSG00000092607.9 | TBX15 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MGA | hg19_v2_chr15_+_41952591_41952672 | -0.49 | 1.5e-02 | Click! |
| TBX15 | hg19_v2_chr1_-_119532127_119532179, hg19_v2_chr1_-_119530428_119530572 | 0.20 | 3.4e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 190 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 1.7 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.2 | 1.3 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.2 | 1.3 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
| 0.0 | 1.2 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 1.1 | GO:0021603 | cranial nerve formation(GO:0021603) |
| 0.0 | 1.1 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.0 | 1.1 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.0 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.0 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.2 | 0.9 | GO:0035803 | egg coat formation(GO:0035803) |
| 0.1 | 0.9 | GO:0038060 | nitric oxide-cGMP-mediated signaling pathway(GO:0038060) |
| 0.1 | 0.9 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.3 | 0.8 | GO:0072579 | molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579) |
| 0.3 | 0.8 | GO:0000412 | histone peptidyl-prolyl isomerization(GO:0000412) |
| 0.2 | 0.8 | GO:0046110 | xanthine metabolic process(GO:0046110) |
| 0.2 | 0.8 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 0.1 | 0.8 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.0 | 0.8 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 59 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 1.4 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 1.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 1.0 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 1.0 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.0 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
| 0.1 | 0.9 | GO:0043219 | lateral loop(GO:0043219) |
| 0.0 | 0.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 0.7 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.0 | 0.7 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 0.6 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 0.5 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.5 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.0 | 0.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342) |
| 0.1 | 0.4 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 0.4 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 108 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 1.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.0 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.1 | 1.0 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 0.9 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.3 | 0.8 | GO:0061599 | molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599) |
| 0.1 | 0.8 | GO:0043546 | molybdopterin cofactor binding(GO:0043546) |
| 0.1 | 0.8 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 0.8 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.7 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.7 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.7 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.2 | 0.6 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.1 | 0.6 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 0.6 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 23 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 1.1 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.1 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.0 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.8 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.8 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.7 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.7 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.7 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.7 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.6 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.5 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
| 0.0 | 0.4 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.4 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.3 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.2 | 0.2 | PID_IL8_CXCR1_PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.2 | PID_FGF_PATHWAY | FGF signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 32 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 1.2 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.1 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.1 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 1.0 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.9 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.9 | REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 0.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.8 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 0.8 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.8 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.8 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.7 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.5 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.5 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.5 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.5 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
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