Motif ID: TBX2

Z-value: 0.677


Transcription factors associated with TBX2:

Gene SymbolEntrez IDGene Name
TBX2 ENSG00000121068.9 TBX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBX2hg19_v2_chr17_+_59477233_594772630.067.6e-01Click!


Activity profile for motif TBX2.

activity profile for motif TBX2


Sorted Z-values histogram for motif TBX2

Sorted Z-values for motif TBX2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_76255444 2.192 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr9_+_33750667 1.641 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
PRSS3


protease, serine, 3


chr9_+_33750515 1.616 ENST00000361005.5
PRSS3
protease, serine, 3
chr1_+_20915409 1.323 ENST00000375071.3
CDA
cytidine deaminase
chr10_+_54074033 1.058 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr2_-_31637560 1.015 ENST00000379416.3
XDH
xanthine dehydrogenase
chr7_-_27135591 1.011 ENST00000343060.4
ENST00000355633.5
HOXA1

homeobox A1

chr11_-_28129656 0.964 ENST00000263181.6
KIF18A
kinesin family member 18A
chr14_-_55658323 0.877 ENST00000554067.1
ENST00000247191.2
DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr10_+_95256356 0.867 ENST00000371485.3
CEP55
centrosomal protein 55kDa
chr2_-_216003127 0.838 ENST00000412081.1
ENST00000272895.7
ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12

chr1_-_200589859 0.803 ENST00000367350.4
KIF14
kinesin family member 14
chr14_-_55658252 0.796 ENST00000395425.2
DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_205391178 0.785 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1



LEM domain containing 1



chr1_+_15736359 0.742 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr2_-_169769787 0.733 ENST00000451987.1
SPC25
SPC25, NDC80 kinetochore complex component
chr10_+_94833642 0.709 ENST00000224356.4
ENST00000394139.1
CYP26A1

cytochrome P450, family 26, subfamily A, polypeptide 1

chr5_+_150639360 0.702 ENST00000523004.1
GM2A
GM2 ganglioside activator
chr14_-_100841670 0.656 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS





tryptophanyl-tRNA synthetase





chr21_+_30502806 0.638 ENST00000399928.1
ENST00000399926.1
MAP3K7CL

MAP3K7 C-terminal like


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0035803 egg coat formation(GO:0035803)
0.1 2.0 GO:0009235 cobalamin metabolic process(GO:0009235)
0.3 1.7 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.5 1.5 GO:0019858 cytosine metabolic process(GO:0019858)
0.0 1.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.4 1.1 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956)
0.3 1.0 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 1.0 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
0.1 1.0 GO:0021603 cranial nerve formation(GO:0021603)
0.1 1.0 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.9 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 0.8 GO:0035627 ceramide transport(GO:0035627)
0.2 0.8 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.2 0.7 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.1 0.7 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.2 0.6 GO:0048627 myoblast development(GO:0048627)
0.1 0.6 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.1 0.6 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.0 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.1 0.9 GO:0090543 Flemming body(GO:0090543)
0.1 0.8 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.2 0.7 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 0.7 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.2 0.6 GO:0000811 GINS complex(GO:0000811)
0.1 0.6 GO:0036021 endolysosome lumen(GO:0036021)
0.1 0.6 GO:0000796 condensin complex(GO:0000796)
0.0 0.6 GO:0097546 ciliary base(GO:0097546)
0.2 0.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.5 GO:0042382 paraspeckles(GO:0042382)
0.0 0.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.4 GO:0032190 acrosin binding(GO:0032190)
0.0 1.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.3 1.0 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.1 1.0 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 0.8 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.0 0.8 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 0.7 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.7 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.7 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.6 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.0 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.6 GO:0043394 proteoglycan binding(GO:0043394)
0.2 0.5 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.5 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 0.6 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.6 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.5 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.4 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.4 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.3 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.9 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.9 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.7 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.7 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
0.0 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway