Motif ID: TBX21_TBR1

Z-value: 1.056

Transcription factors associated with TBX21_TBR1:

Gene SymbolEntrez IDGene Name
TBR1 ENSG00000136535.10 TBR1
TBX21 ENSG00000073861.2 TBX21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBX21hg19_v2_chr17_+_45810594_45810610-0.433.5e-02Click!
TBR1hg19_v2_chr2_+_162272605_1622727530.193.7e-01Click!


Activity profile for motif TBX21_TBR1.

activity profile for motif TBX21_TBR1


Sorted Z-values histogram for motif TBX21_TBR1

Sorted Z-values for motif TBX21_TBR1



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX21_TBR1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_94727048 10.728 ENST00000283357.5
 FAM81B
family with sequence similarity 81, member B
chr1_+_38022572 9.897 ENST00000541606.1
 DNALI1
dynein, axonemal, light intermediate chain 1
chr1_+_38022513 8.827 ENST00000296218.7
 DNALI1
dynein, axonemal, light intermediate chain 1
chr11_+_73358594 7.429 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1


pleckstrin homology domain containing, family B (evectins) member 1


chr19_-_7990991 6.087 ENST00000318978.4
 CTXN1
cortexin 1
chr4_-_177116772 4.661 ENST00000280191.2
 SPATA4
spermatogenesis associated 4
chr5_-_35938674 4.630 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr7_-_120497178 3.861 ENST00000441017.1
ENST00000424710.1
ENST00000433758.1
 TSPAN12


tetraspanin 12


chr2_+_228736321 3.734 ENST00000309931.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr11_+_6260298 3.699 ENST00000379936.2
 CNGA4
cyclic nucleotide gated channel alpha 4
chr3_-_66551397 3.427 ENST00000383703.3
 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr2_+_228736335 3.350 ENST00000440997.1
ENST00000545118.1
 DAW1

dynein assembly factor with WDR repeat domains 1

chr3_-_66551351 3.262 ENST00000273261.3
 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr3_-_100712352 3.223 ENST00000471714.1
ENST00000284322.5
 ABI3BP

ABI family, member 3 (NESH) binding protein

chr16_-_67450325 2.986 ENST00000348579.2
 ZDHHC1
zinc finger, DHHC-type containing 1
chr14_+_95078714 2.600 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
 SERPINA3


serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3


chr12_+_69742121 2.510 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
 LYZ


lysozyme


chr17_-_56406117 2.510 ENST00000268893.6
ENST00000355701.3
 BZRAP1

benzodiazepine receptor (peripheral) associated protein 1

chr5_+_140571902 2.483 ENST00000239446.4
 PCDHB10
protocadherin beta 10
chr13_-_39564993 2.453 ENST00000423210.1
 STOML3
stomatin (EPB72)-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 7.6 GO:0007602 phototransduction(GO:0007602)
1.3 6.7 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 4.7 GO:0007220 Notch receptor processing(GO:0007220)
0.1 4.0 GO:0010842 retina layer formation(GO:0010842)
0.4 3.7 GO:0015889 cobalamin transport(GO:0015889)
0.1 3.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 3.0 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 2.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 2.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 2.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 2.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.8 2.3 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1 2.0 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.9 GO:0007608 sensory perception of smell(GO:0007608)
0.6 1.8 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.4 1.8 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 1.7 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 1.7 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.7 GO:0030286 dynein complex(GO:0030286)
0.0 8.0 GO:0005929 cilium(GO:0005929)
0.0 5.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.4 4.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 4.3 GO:0043202 lysosomal lumen(GO:0043202)
0.1 3.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 3.5 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 3.2 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 3.1 GO:0005614 interstitial matrix(GO:0005614)
0.8 2.3 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 2.2 GO:0032590 dendrite membrane(GO:0032590)
0.0 2.0 GO:0036064 ciliary basal body(GO:0036064)
0.0 2.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.0 GO:0001650 fibrillar center(GO:0001650)
0.2 1.9 GO:0044294 dendritic growth cone(GO:0044294)
0.0 1.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 1.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.5 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.2 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 18.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 4.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 3.7 GO:0031419 cobalamin binding(GO:0031419)
0.3 3.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 3.5 GO:0005518 collagen binding(GO:0005518)
0.1 3.1 GO:0030552 cAMP binding(GO:0030552)
0.1 3.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 2.5 GO:0003796 lysozyme activity(GO:0003796)
0.1 2.4 GO:0015643 toxic substance binding(GO:0015643)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 1.9 GO:0070888 E-box binding(GO:0070888)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 1.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 1.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 1.6 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.2 1.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 1.5 GO:0038132 neuregulin binding(GO:0038132)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 4.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 4.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 1.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.3 4.8 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.2 3.8 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.3 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 2.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 2.1 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 2.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.6 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 1.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.5 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 1.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 0.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.7 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis