Motif ID: TBX3

Z-value: 0.474


Transcription factors associated with TBX3:

Gene SymbolEntrez IDGene Name
TBX3 ENSG00000135111.10 TBX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBX3hg19_v2_chr12_-_115121962_115121987-0.067.8e-01Click!


Activity profile for motif TBX3.

activity profile for motif TBX3


Sorted Z-values histogram for motif TBX3

Sorted Z-values for motif TBX3



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_+_56725952 1.501 ENST00000371168.3
 C20orf85
chromosome 20 open reading frame 85
chr22_+_24891210 0.555 ENST00000382760.2
 UPB1
ureidopropionase, beta
chr6_+_52285131 0.539 ENST00000433625.2
 EFHC1
EF-hand domain (C-terminal) containing 1
chr11_-_1629693 0.511 ENST00000399685.1
 KRTAP5-3
keratin associated protein 5-3
chr7_+_76751926 0.504 ENST00000285871.4
ENST00000431197.1
 CCDC146

coiled-coil domain containing 146

chr14_-_106642049 0.475 ENST00000390605.2
 IGHV1-18
immunoglobulin heavy variable 1-18
chr19_-_55677920 0.472 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr16_+_58283814 0.459 ENST00000443128.2
ENST00000219299.4
 CCDC113

coiled-coil domain containing 113

chr12_+_12223867 0.439 ENST00000308721.5
 BCL2L14
BCL2-like 14 (apoptosis facilitator)
chr7_-_138386097 0.433 ENST00000421622.1
 SVOPL
SVOP-like
chr14_-_21270561 0.394 ENST00000412779.2
 RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr2_-_217560248 0.377 ENST00000233813.4
 IGFBP5
insulin-like growth factor binding protein 5
chr1_+_162351503 0.360 ENST00000458626.2
 C1orf226
chromosome 1 open reading frame 226
chr17_+_26800756 0.357 ENST00000537681.1
 SLC13A2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr6_+_52285046 0.356 ENST00000371068.5
 EFHC1
EF-hand domain (C-terminal) containing 1
chr14_-_21270995 0.332 ENST00000555698.1
ENST00000397970.4
ENST00000340900.3
 RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr19_-_9092018 0.329 ENST00000397910.4
 MUC16
mucin 16, cell surface associated
chr6_-_52668605 0.328 ENST00000334575.5
 GSTA1
glutathione S-transferase alpha 1
chr19_-_7766991 0.322 ENST00000597921.1
ENST00000346664.5
 FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr19_+_1077393 0.312 ENST00000590577.1
 HMHA1
histocompatibility (minor) HA-1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 0.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 0.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.6 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.6 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.4 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0 0.3 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.3 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.1 0.2 GO:0036378 alkaloid catabolic process(GO:0009822) calcitriol biosynthetic process from calciol(GO:0036378)
0.0 0.2 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0 0.2 GO:0019249 lactate biosynthetic process(GO:0019249)
0.0 0.2 GO:2000852 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.1 GO:0072579 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.1 GO:0010446 response to alkaline pH(GO:0010446)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.3 GO:0032010 phagolysosome(GO:0032010)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0032044 DSIF complex(GO:0032044)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.0 GO:0097179 protease inhibitor complex(GO:0097179)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.7 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.4 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.1 0.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0019863 IgE binding(GO:0019863)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 0.2 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.2 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.1 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis