Motif ID: TBX4

Z-value: 0.485


Transcription factors associated with TBX4:

Gene SymbolEntrez IDGene Name
TBX4 ENSG00000121075.5 TBX4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBX4hg19_v2_chr17_+_59529743_59529798-0.077.6e-01Click!


Activity profile for motif TBX4.

activity profile for motif TBX4


Sorted Z-values histogram for motif TBX4

Sorted Z-values for motif TBX4



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4

PNG image of the network

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Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_73358594 2.566 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1


pleckstrin homology domain containing, family B (evectins) member 1


chr9_-_75567962 1.722 ENST00000297785.3
ENST00000376939.1
 ALDH1A1

aldehyde dehydrogenase 1 family, member A1

chr11_-_5248294 1.113 ENST00000335295.4
 HBB
hemoglobin, beta
chr13_-_36429763 0.959 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr3_-_66551397 0.932 ENST00000383703.3
 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr11_+_86511549 0.892 ENST00000533902.2
 PRSS23
protease, serine, 23
chr3_-_66551351 0.889 ENST00000273261.3
 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr20_+_44098346 0.886 ENST00000372676.3
 WFDC2
WAP four-disulfide core domain 2
chr17_+_35849937 0.722 ENST00000394389.4
 DUSP14
dual specificity phosphatase 14
chr11_-_34535332 0.718 ENST00000257832.2
ENST00000429939.2
 ELF5

E74-like factor 5 (ets domain transcription factor)

chr11_-_34535297 0.668 ENST00000532417.1
 ELF5
E74-like factor 5 (ets domain transcription factor)
chr6_+_39760129 0.641 ENST00000274867.4
 DAAM2
dishevelled associated activator of morphogenesis 2
chr2_-_157189180 0.581 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
 NR4A2




nuclear receptor subfamily 4, group A, member 2




chr1_+_114472222 0.571 ENST00000369558.1
ENST00000369561.4
 HIPK1

homeodomain interacting protein kinase 1

chr20_+_44098385 0.569 ENST00000217425.5
ENST00000339946.3
 WFDC2

WAP four-disulfide core domain 2

chr17_-_7232585 0.565 ENST00000571887.1
ENST00000315614.7
ENST00000399464.2
ENST00000570460.1
 NEURL4



neuralized E3 ubiquitin protein ligase 4



chr11_+_1940786 0.551 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
 TNNT3




troponin T type 3 (skeletal, fast)




chr1_+_114471809 0.530 ENST00000426820.2
 HIPK1
homeodomain interacting protein kinase 1
chr1_+_114472481 0.530 ENST00000369555.2
 HIPK1
homeodomain interacting protein kinase 1
chr11_-_33913708 0.522 ENST00000257818.2
 LMO2
LIM domain only 2 (rhombotin-like 1)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0007602 phototransduction(GO:0007602)
0.2 2.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.4 1.8 GO:0032474 otolith morphogenesis(GO:0032474)
0.4 1.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 1.4 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 1.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.3 1.1 GO:0030185 nitric oxide transport(GO:0030185)
0.0 1.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.9 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 0.7 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.7 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 0.6 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.2 0.5 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 0.4 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.4 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.3 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.6 GO:0005861 troponin complex(GO:0005861)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.5 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.4 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.2 1.5 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 1.4 GO:0070888 E-box binding(GO:0070888)
0.1 1.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.1 GO:0030492 hemoglobin binding(GO:0030492)
0.2 0.7 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0 0.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 0.6 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.5 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.5 GO:0097001 ceramide binding(GO:0097001)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.4 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.3 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 0.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0 0.2 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.7 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation