Motif ID: TBX5
Z-value: 0.776
Transcription factors associated with TBX5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
TBX5 | ENSG00000089225.15 | TBX5 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
TBX5 | hg19_v2_chr12_-_114841703_114841726 | 0.33 | 1.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 3.1 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
0.3 | 0.8 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
0.3 | 0.8 | GO:0032824 | natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714) |
0.2 | 0.7 | GO:1900073 | regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075) |
0.2 | 0.7 | GO:1904328 | regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) |
0.2 | 1.8 | GO:0001661 | conditioned taste aversion(GO:0001661) |
0.2 | 0.6 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
0.2 | 0.2 | GO:0016539 | intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) |
0.2 | 0.7 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
0.2 | 0.6 | GO:0035627 | ceramide transport(GO:0035627) |
0.1 | 2.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
0.1 | 1.2 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.1 | 0.4 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
0.1 | 0.5 | GO:0003241 | growth involved in heart morphogenesis(GO:0003241) |
0.1 | 0.4 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
0.1 | 0.8 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
0.1 | 0.4 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
0.1 | 1.0 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.1 | 0.3 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
0.1 | 0.6 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
0.1 | 0.4 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
0.1 | 0.8 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
0.1 | 0.1 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
0.1 | 0.4 | GO:0030311 | poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
0.1 | 0.5 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
0.1 | 0.4 | GO:0033159 | negative regulation of protein import into nucleus, translocation(GO:0033159) |
0.1 | 0.4 | GO:0042361 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
0.1 | 0.6 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
0.1 | 0.7 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
0.1 | 0.7 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
0.1 | 0.3 | GO:0042938 | dipeptide transport(GO:0042938) |
0.1 | 0.3 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
0.1 | 0.3 | GO:0021986 | epithalamus development(GO:0021538) habenula development(GO:0021986) |
0.1 | 0.3 | GO:0060474 | positive regulation of sperm motility involved in capacitation(GO:0060474) |
0.1 | 0.5 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
0.1 | 0.3 | GO:0045014 | carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) |
0.1 | 0.3 | GO:2001037 | tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037) |
0.1 | 0.3 | GO:0035803 | egg coat formation(GO:0035803) |
0.1 | 0.2 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) |
0.1 | 0.5 | GO:1904823 | pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
0.1 | 0.4 | GO:0032425 | positive regulation of mismatch repair(GO:0032425) |
0.1 | 0.3 | GO:0021553 | olfactory nerve development(GO:0021553) |
0.1 | 0.4 | GO:0021938 | ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) |
0.1 | 0.2 | GO:0007518 | myoblast fate determination(GO:0007518) |
0.1 | 0.6 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
0.1 | 0.4 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
0.1 | 0.6 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
0.1 | 0.2 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
0.1 | 0.2 | GO:0043397 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020) |
0.1 | 0.6 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
0.1 | 0.4 | GO:2000490 | negative regulation of hepatic stellate cell activation(GO:2000490) |
0.1 | 0.2 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
0.1 | 0.3 | GO:0070980 | biphenyl catabolic process(GO:0070980) |
0.1 | 0.7 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 0.2 | GO:2000870 | positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870) |
0.1 | 0.4 | GO:0010193 | response to ozone(GO:0010193) |
0.1 | 0.2 | GO:0008050 | female courtship behavior(GO:0008050) |
0.1 | 0.2 | GO:0031247 | actin rod assembly(GO:0031247) |
0.1 | 0.4 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
0.1 | 0.5 | GO:0010533 | regulation of activation of Janus kinase activity(GO:0010533) |
0.1 | 0.3 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
0.0 | 0.2 | GO:1904075 | trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
0.0 | 0.1 | GO:0061386 | closure of optic fissure(GO:0061386) |
0.0 | 0.3 | GO:0042335 | cuticle development(GO:0042335) |
0.0 | 1.1 | GO:0035646 | endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757) |
0.0 | 0.2 | GO:0046668 | regulation of retinal cell programmed cell death(GO:0046668) |
0.0 | 0.1 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
0.0 | 0.0 | GO:0051710 | regulation of cytolysis in other organism(GO:0051710) |
0.0 | 0.4 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
0.0 | 0.1 | GO:0097156 | fasciculation of motor neuron axon(GO:0097156) |
0.0 | 0.3 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
0.0 | 0.3 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
0.0 | 0.1 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
0.0 | 0.1 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
0.0 | 0.2 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
0.0 | 0.3 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
0.0 | 0.3 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
0.0 | 0.2 | GO:0044878 | mitotic cytokinesis checkpoint(GO:0044878) |
0.0 | 0.2 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
0.0 | 0.4 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
0.0 | 0.4 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
0.0 | 0.4 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
0.0 | 0.6 | GO:0023041 | neuronal signal transduction(GO:0023041) |
0.0 | 0.2 | GO:0007525 | somatic muscle development(GO:0007525) |
0.0 | 0.1 | GO:0019087 | transformation of host cell by virus(GO:0019087) |
0.0 | 0.1 | GO:0098838 | reduced folate transmembrane transport(GO:0098838) |
0.0 | 0.5 | GO:0051639 | actin filament network formation(GO:0051639) |
0.0 | 0.1 | GO:0002290 | gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193) |
0.0 | 0.1 | GO:0051541 | elastin metabolic process(GO:0051541) |
0.0 | 0.1 | GO:0006172 | ADP biosynthetic process(GO:0006172) |
0.0 | 0.2 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
0.0 | 0.1 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
0.0 | 0.2 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
0.0 | 0.1 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
0.0 | 0.2 | GO:0038110 | interleukin-2-mediated signaling pathway(GO:0038110) |
0.0 | 0.2 | GO:0060492 | foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) |
0.0 | 0.2 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
0.0 | 0.1 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
0.0 | 0.6 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
0.0 | 0.1 | GO:0010728 | regulation of hydrogen peroxide biosynthetic process(GO:0010728) |
0.0 | 0.6 | GO:0045618 | positive regulation of keratinocyte differentiation(GO:0045618) |
0.0 | 0.5 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
0.0 | 0.1 | GO:0007343 | egg activation(GO:0007343) |
0.0 | 0.2 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
0.0 | 0.2 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
0.0 | 0.1 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
0.0 | 0.1 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
0.0 | 0.1 | GO:0030421 | defecation(GO:0030421) |
0.0 | 0.1 | GO:0021633 | optic nerve structural organization(GO:0021633) |
0.0 | 0.3 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.4 | GO:0034063 | stress granule assembly(GO:0034063) |
0.0 | 0.2 | GO:1901843 | positive regulation of high voltage-gated calcium channel activity(GO:1901843) |
0.0 | 0.1 | GO:0007439 | ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611) |
0.0 | 0.1 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
0.0 | 0.2 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
0.0 | 0.5 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
0.0 | 0.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.0 | 0.1 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
0.0 | 0.2 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
0.0 | 0.1 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
0.0 | 0.1 | GO:0015015 | heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015) |
0.0 | 0.3 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
0.0 | 0.1 | GO:0051835 | positive regulation of synapse structural plasticity(GO:0051835) |
0.0 | 0.1 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
0.0 | 0.2 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
0.0 | 0.3 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
0.0 | 0.1 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) |
0.0 | 0.2 | GO:0030091 | protein repair(GO:0030091) |
0.0 | 0.1 | GO:0099540 | synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) |
0.0 | 0.3 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.0 | 0.0 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
0.0 | 0.6 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 1.1 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
0.0 | 0.1 | GO:0014826 | cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826) |
0.0 | 0.3 | GO:0090527 | actin filament reorganization(GO:0090527) |
0.0 | 0.1 | GO:0045792 | negative regulation of cell size(GO:0045792) |
0.0 | 0.2 | GO:0071593 | T cell activation(GO:0042110) leukocyte aggregation(GO:0070486) T cell aggregation(GO:0070489) lymphocyte aggregation(GO:0071593) |
0.0 | 0.1 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564) |
0.0 | 0.3 | GO:0045116 | protein neddylation(GO:0045116) |
0.0 | 0.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.0 | 0.2 | GO:0036149 | phosphatidylinositol acyl-chain remodeling(GO:0036149) |
0.0 | 0.0 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
0.0 | 0.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
0.0 | 0.3 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
0.0 | 0.3 | GO:0007567 | parturition(GO:0007567) |
0.0 | 0.1 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
0.0 | 0.1 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
0.0 | 0.4 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
0.0 | 0.0 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
0.0 | 1.6 | GO:0006939 | smooth muscle contraction(GO:0006939) |
0.0 | 0.1 | GO:0010482 | epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482) |
0.0 | 0.0 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
0.0 | 0.1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
0.0 | 0.1 | GO:0034378 | chylomicron assembly(GO:0034378) |
0.0 | 0.2 | GO:0042104 | positive regulation of activated T cell proliferation(GO:0042104) |
0.0 | 0.3 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
0.0 | 0.0 | GO:0002775 | antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.8 | GO:0035976 | AP1 complex(GO:0035976) |
0.1 | 0.6 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.1 | 0.5 | GO:0071458 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) |
0.1 | 0.8 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
0.1 | 0.3 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
0.1 | 0.4 | GO:0030934 | anchoring collagen complex(GO:0030934) |
0.1 | 0.6 | GO:0097209 | epidermal lamellar body(GO:0097209) |
0.1 | 0.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
0.1 | 0.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
0.1 | 0.4 | GO:0031262 | Ndc80 complex(GO:0031262) |
0.1 | 0.4 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
0.1 | 0.3 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
0.0 | 0.7 | GO:0099634 | postsynaptic specialization membrane(GO:0099634) |
0.0 | 0.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
0.0 | 0.2 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062) |
0.0 | 0.2 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
0.0 | 0.2 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
0.0 | 0.7 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
0.0 | 0.1 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
0.0 | 0.4 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 0.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
0.0 | 0.7 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.5 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
0.0 | 0.1 | GO:0032279 | asymmetric synapse(GO:0032279) |
0.0 | 1.8 | GO:0001533 | cornified envelope(GO:0001533) |
0.0 | 0.4 | GO:0031209 | SCAR complex(GO:0031209) |
0.0 | 2.2 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.0 | 0.6 | GO:0031264 | death-inducing signaling complex(GO:0031264) |
0.0 | 0.2 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.0 | 0.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.0 | 0.7 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 0.2 | GO:0042382 | paraspeckles(GO:0042382) |
0.0 | 0.6 | GO:0030425 | dendrite(GO:0030425) |
0.0 | 0.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.0 | 0.3 | GO:0032433 | filopodium tip(GO:0032433) |
0.0 | 1.8 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.0 | 0.0 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.0 | 0.1 | GO:1990745 | EARP complex(GO:1990745) |
0.0 | 0.8 | GO:0031904 | endosome lumen(GO:0031904) |
0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
0.0 | 0.6 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
0.0 | 0.1 | GO:0070876 | SOSS complex(GO:0070876) |
0.0 | 0.1 | GO:0071203 | WASH complex(GO:0071203) |
0.0 | 0.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.0 | 0.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 0.9 | GO:0002102 | podosome(GO:0002102) |
0.0 | 0.1 | GO:0036449 | microtubule minus-end(GO:0036449) |
0.0 | 0.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
0.0 | 0.1 | GO:0005787 | signal peptidase complex(GO:0005787) |
0.0 | 0.1 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
0.0 | 0.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.1 | GO:0031931 | TORC1 complex(GO:0031931) |
0.0 | 0.9 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.1 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
0.4 | 1.7 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
0.3 | 0.8 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
0.3 | 0.8 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
0.2 | 0.9 | GO:0034040 | lipid-transporting ATPase activity(GO:0034040) |
0.2 | 0.6 | GO:0045518 | interleukin-22 receptor binding(GO:0045518) |
0.2 | 0.8 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
0.2 | 0.6 | GO:0038131 | neuregulin receptor activity(GO:0038131) |
0.2 | 0.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
0.1 | 0.8 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
0.1 | 1.2 | GO:0043426 | MRF binding(GO:0043426) |
0.1 | 0.4 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
0.1 | 0.4 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
0.1 | 0.5 | GO:0015389 | pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389) |
0.1 | 0.4 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
0.1 | 0.3 | GO:0005148 | prolactin receptor binding(GO:0005148) |
0.1 | 0.6 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
0.1 | 0.4 | GO:0047888 | fatty acid peroxidase activity(GO:0047888) |
0.1 | 0.7 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.1 | 0.6 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
0.1 | 0.3 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
0.1 | 0.4 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
0.1 | 0.4 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.1 | 0.7 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
0.1 | 0.2 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
0.1 | 0.3 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) oligopeptide transmembrane transporter activity(GO:0035673) |
0.1 | 0.1 | GO:1990763 | arrestin family protein binding(GO:1990763) |
0.1 | 0.8 | GO:0008517 | folic acid transporter activity(GO:0008517) |
0.1 | 0.3 | GO:0010465 | nerve growth factor receptor activity(GO:0010465) |
0.1 | 0.4 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
0.1 | 0.3 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.1 | 0.3 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.1 | 0.2 | GO:0004917 | interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917) |
0.1 | 0.3 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
0.1 | 0.3 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
0.0 | 0.1 | GO:0005136 | interleukin-4 receptor binding(GO:0005136) |
0.0 | 0.3 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
0.0 | 0.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.0 | 0.3 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
0.0 | 0.1 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
0.0 | 1.7 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.0 | 3.5 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
0.0 | 0.5 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
0.0 | 0.1 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
0.0 | 0.1 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
0.0 | 0.3 | GO:0097016 | L27 domain binding(GO:0097016) |
0.0 | 0.3 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
0.0 | 0.7 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
0.0 | 0.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.0 | 0.2 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
0.0 | 0.8 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.1 | GO:0017095 | heparan sulfate 6-O-sulfotransferase activity(GO:0017095) |
0.0 | 0.3 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
0.0 | 0.3 | GO:0032190 | acrosin binding(GO:0032190) |
0.0 | 0.3 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
0.0 | 0.1 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
0.0 | 0.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
0.0 | 0.2 | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) |
0.0 | 0.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.0 | 0.3 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
0.0 | 0.1 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
0.0 | 2.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 0.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
0.0 | 0.2 | GO:0019958 | C-X-C chemokine binding(GO:0019958) |
0.0 | 0.3 | GO:0019957 | C-C chemokine binding(GO:0019957) |
0.0 | 0.4 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.0 | 0.3 | GO:0003680 | AT DNA binding(GO:0003680) |
0.0 | 0.2 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
0.0 | 0.2 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
0.0 | 1.4 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 0.1 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
0.0 | 0.4 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
0.0 | 0.3 | GO:0031014 | troponin T binding(GO:0031014) |
0.0 | 0.1 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
0.0 | 0.2 | GO:0070324 | thyroid hormone binding(GO:0070324) |
0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
0.0 | 0.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
0.0 | 0.3 | GO:0005549 | odorant binding(GO:0005549) |
0.0 | 0.1 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
0.0 | 0.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.1 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
0.0 | 0.1 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
0.0 | 0.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.0 | 0.2 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
0.0 | 0.0 | GO:0016503 | pheromone receptor activity(GO:0016503) |
0.0 | 0.1 | GO:0060175 | brain-derived neurotrophic factor-activated receptor activity(GO:0060175) |
0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 0.1 | GO:0043237 | laminin-1 binding(GO:0043237) |
0.0 | 0.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
0.0 | 0.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 0.1 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.0 | 0.1 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
0.0 | 0.1 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.0 | 0.1 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
0.0 | 0.1 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
0.0 | 0.3 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
0.0 | 0.0 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.0 | 0.1 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
0.0 | 0.1 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
0.0 | 0.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.0 | 0.2 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
0.0 | 1.1 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.1 | GO:0004046 | aminoacylase activity(GO:0004046) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.8 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
0.1 | 1.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 1.3 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
0.0 | 1.2 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
0.0 | 0.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.0 | 0.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
0.0 | 2.6 | PID_CDC42_PATHWAY | CDC42 signaling events |
0.0 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 0.6 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
0.0 | 0.6 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.0 | 0.4 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.0 | 0.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 0.2 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.0 | 0.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.0 | 0.5 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.0 | 0.6 | PID_ENDOTHELIN_PATHWAY | Endothelins |
0.0 | 0.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.0 | 0.5 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
0.0 | 0.5 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
0.0 | 0.3 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
0.0 | 0.3 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
0.0 | 0.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.0 | 0.2 | PID_ER_NONGENOMIC_PATHWAY | Plasma membrane estrogen receptor signaling |
0.0 | 0.4 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.7 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
0.0 | 0.3 | PID_IFNG_PATHWAY | IFN-gamma pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.8 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.1 | 1.1 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.1 | 0.6 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
0.0 | 1.1 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 0.7 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.0 | 0.9 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
0.0 | 0.7 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
0.0 | 1.9 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
0.0 | 0.6 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.0 | 0.7 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
0.0 | 1.1 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 0.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
0.0 | 0.3 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
0.0 | 0.4 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
0.0 | 0.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.8 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.0 | 0.4 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
0.0 | 0.7 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
0.0 | 0.6 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
0.0 | 0.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.0 | 0.4 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
0.0 | 0.3 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
0.0 | 0.8 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
0.0 | 0.5 | REACTOME_KINESINS | Genes involved in Kinesins |
0.0 | 0.2 | REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
0.0 | 0.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
0.0 | 0.2 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
0.0 | 0.6 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.0 | 0.2 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
0.0 | 0.4 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.4 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.0 | 0.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 0.2 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.0 | 0.3 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
0.0 | 0.3 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |