Motif ID: TBX5

Z-value: 0.776


Transcription factors associated with TBX5:

Gene SymbolEntrez IDGene Name
TBX5 ENSG00000089225.15 TBX5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBX5hg19_v2_chr12_-_114841703_1148417260.331.1e-01Click!


Activity profile for motif TBX5.

activity profile for motif TBX5


Sorted Z-values histogram for motif TBX5

Sorted Z-values for motif TBX5



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_31488433 1.557 ENST00000455608.1
SMTN
smoothelin
chr14_+_75746781 1.219 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr4_-_175443788 1.179 ENST00000541923.1
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr4_-_175443484 1.107 ENST00000514584.1
ENST00000542498.1
ENST00000296521.7
ENST00000422112.2
ENST00000504433.1
HPGD




hydroxyprostaglandin dehydrogenase 15-(NAD)




chr21_+_30502806 1.057 ENST00000399928.1
ENST00000399926.1
MAP3K7CL

MAP3K7 C-terminal like

chr9_+_125137565 1.047 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_-_2170786 1.026 ENST00000300632.5
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_40174565 1.018 ENST00000309930.5
ENST00000401647.2
ENST00000335693.4
ENST00000413931.1
ENST00000416370.1
ENST00000540834.1
C7orf10





succinylCoA:glutarate-CoA transferase





chr13_-_60738003 1.010 ENST00000400330.1
ENST00000400324.4
DIAPH3

diaphanous-related formin 3

chr13_-_60737898 0.934 ENST00000377908.2
ENST00000400319.1
ENST00000400320.1
ENST00000267215.4
DIAPH3



diaphanous-related formin 3



chr14_+_24540046 0.931 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6



copine VI (neuronal)



chr1_+_15736359 0.919 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chr1_+_8378140 0.886 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr13_+_78109884 0.885 ENST00000377246.3
ENST00000349847.3
SCEL

sciellin

chr11_-_58345569 0.883 ENST00000528954.1
ENST00000528489.1
LPXN

leupaxin

chr20_+_306177 0.871 ENST00000544632.1
SOX12
SRY (sex determining region Y)-box 12
chr16_-_2205352 0.844 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5
chr13_+_78109804 0.827 ENST00000535157.1
SCEL
sciellin
chr17_+_74372662 0.819 ENST00000591651.1
ENST00000545180.1
SPHK1

sphingosine kinase 1

chr8_-_144655141 0.802 ENST00000398882.3
MROH6
maestro heat-like repeat family member 6
chr4_-_175443943 0.779 ENST00000296522.6
HPGD
hydroxyprostaglandin dehydrogenase 15-(NAD)
chr4_-_73434498 0.761 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr19_-_46526304 0.758 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr12_+_107712173 0.715 ENST00000280758.5
ENST00000420571.2
BTBD11

BTB (POZ) domain containing 11

chr7_+_143013198 0.713 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr18_+_33877654 0.701 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3



formin homology 2 domain containing 3



chrX_-_106959631 0.700 ENST00000486554.1
ENST00000372390.4
TSC22D3

TSC22 domain family, member 3

chr8_+_87111059 0.685 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr17_-_8059638 0.665 ENST00000584202.1
ENST00000354903.5
ENST00000577253.1
PER1


period circadian clock 1


chr9_+_125133315 0.646 ENST00000223423.4
ENST00000362012.2
PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr1_-_153521714 0.636 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr3_-_48594248 0.614 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
PFKFB4





6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4





chr7_-_27135591 0.612 ENST00000343060.4
ENST00000355633.5
HOXA1

homeobox A1

chr19_+_16308711 0.610 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr14_+_75745477 0.607 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS




FBJ murine osteosarcoma viral oncogene homolog




chr2_-_216003127 0.605 ENST00000412081.1
ENST00000272895.7
ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12

chr2_+_174219548 0.577 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
CDCA7




cell division cycle associated 7




chr5_+_54320078 0.577 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr15_+_85427879 0.575 ENST00000338602.2
ENST00000537216.1
ENST00000538177.1
ENST00000537624.1
SLC28A1



solute carrier family 28 (concentrative nucleoside transporter), member 1



chr11_-_72385437 0.570 ENST00000418754.2
ENST00000542969.2
ENST00000334456.5
PDE2A


phosphodiesterase 2A, cGMP-stimulated


chr11_+_35198118 0.567 ENST00000525211.1
ENST00000526000.1
ENST00000279452.6
ENST00000527889.1
CD44



CD44 molecule (Indian blood group)



chr7_+_155090271 0.566 ENST00000476756.1
INSIG1
insulin induced gene 1
chr6_+_34204642 0.563 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1




high mobility group AT-hook 1




chr22_-_20231207 0.558 ENST00000425986.1
RTN4R
reticulon 4 receptor
chr14_+_21467414 0.551 ENST00000554422.1
ENST00000298681.4
SLC39A2

solute carrier family 39 (zinc transporter), member 2

chr6_-_11382478 0.525 ENST00000397378.3
ENST00000513989.1
ENST00000508546.1
ENST00000504387.1
NEDD9



neural precursor cell expressed, developmentally down-regulated 9



chr4_+_102268904 0.516 ENST00000527564.1
ENST00000529296.1
AP001816.1

Uncharacterized protein

chr10_+_94352956 0.514 ENST00000260731.3
KIF11
kinesin family member 11
chrX_+_70503037 0.512 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chr5_-_127418573 0.510 ENST00000508353.1
ENST00000508878.1
ENST00000501652.1
ENST00000514409.1
CTC-228N24.3



CTC-228N24.3



chrX_-_106960285 0.503 ENST00000503515.1
ENST00000372397.2
TSC22D3

TSC22 domain family, member 3

chr5_-_54281407 0.501 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr19_+_16308659 0.499 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1


adaptor-related protein complex 1, mu 1 subunit


chr19_+_10397648 0.495 ENST00000340992.4
ENST00000393717.2
ICAM4

intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

chr20_+_306221 0.490 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chr15_-_71055769 0.483 ENST00000539319.1
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr14_-_37051798 0.480 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr1_+_150954493 0.465 ENST00000368947.4
ANXA9
annexin A9
chr7_+_76139833 0.455 ENST00000257632.5
UPK3B
uroplakin 3B
chr3_+_167453493 0.449 ENST00000295777.5
ENST00000472747.2
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr20_-_32891151 0.442 ENST00000217426.2
AHCY
adenosylhomocysteinase
chrX_-_109561294 0.442 ENST00000372059.2
ENST00000262844.5
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr7_+_139529040 0.441 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr16_+_55600580 0.436 ENST00000457326.2
CAPNS2
calpain, small subunit 2
chr19_-_41934635 0.434 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr17_-_39203519 0.430 ENST00000542137.1
ENST00000391419.3
KRTAP2-1

keratin associated protein 2-1

chr19_-_16045220 0.421 ENST00000326742.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr4_-_186456652 0.418 ENST00000284767.5
ENST00000284770.5
PDLIM3

PDZ and LIM domain 3

chr4_-_186456766 0.413 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr17_+_43922241 0.413 ENST00000329196.5
SPPL2C
signal peptide peptidase like 2C
chr2_+_201676908 0.410 ENST00000409226.1
ENST00000452790.2
BZW1

basic leucine zipper and W2 domains 1

chr10_-_131762105 0.409 ENST00000368648.3
ENST00000355311.5
EBF3

early B-cell factor 3

chr7_+_139528952 0.409 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr3_-_48632593 0.405 ENST00000454817.1
ENST00000328333.8
COL7A1

collagen, type VII, alpha 1

chr19_+_10397621 0.403 ENST00000380770.3
ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr2_-_169769787 0.401 ENST00000451987.1
SPC25
SPC25, NDC80 kinetochore complex component
chrX_-_148713365 0.399 ENST00000511776.1
ENST00000507237.1
TMEM185A

transmembrane protein 185A

chr17_+_37894179 0.396 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7


growth factor receptor-bound protein 7


chr19_+_41856816 0.395 ENST00000539627.1
TMEM91
transmembrane protein 91
chr11_-_85779971 0.393 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr19_+_54385439 0.392 ENST00000536044.1
ENST00000540413.1
ENST00000263431.3
ENST00000419486.1
PRKCG



protein kinase C, gamma



chrX_-_153775426 0.388 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr6_+_121756809 0.384 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr12_+_57853918 0.382 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1



GLI family zinc finger 1



chr2_+_68961934 0.372 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr10_+_135340859 0.372 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1


cytochrome P450, family 2, subfamily E, polypeptide 1


chr2_+_234601512 0.368 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr2_+_171673072 0.365 ENST00000358196.3
ENST00000375272.1
GAD1

glutamate decarboxylase 1 (brain, 67kDa)

chr5_-_176836577 0.362 ENST00000253496.3
F12
coagulation factor XII (Hageman factor)
chr17_-_74533734 0.360 ENST00000589342.1
CYGB
cytoglobin
chr19_-_10420459 0.360 ENST00000403352.1
ENST00000403903.3
ZGLP1

zinc finger, GATA-like protein 1

chr17_+_34538310 0.357 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
CCL4L1











chemokine (C-C motif) ligand 4-like 1











chr8_+_32405785 0.356 ENST00000287842.3
NRG1
neuregulin 1
chr19_-_42931567 0.356 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr8_+_32405728 0.356 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1




neuregulin 1




chr3_+_135741576 0.353 ENST00000334546.2
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr1_+_207038699 0.350 ENST00000367098.1
IL20
interleukin 20
chr7_+_143318020 0.350 ENST00000444908.2
ENST00000518791.1
ENST00000411497.2
FAM115C


family with sequence similarity 115, member C


chr1_+_13910479 0.350 ENST00000509009.1
PDPN
podoplanin
chr13_+_30510003 0.348 ENST00000400540.1
LINC00544
long intergenic non-protein coding RNA 544
chr4_+_8582287 0.348 ENST00000382487.4
GPR78
G protein-coupled receptor 78
chr2_+_68961905 0.347 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr17_-_72358001 0.346 ENST00000375366.3
BTBD17
BTB (POZ) domain containing 17
chr11_-_88796803 0.341 ENST00000418177.2
ENST00000455756.2
GRM5

glutamate receptor, metabotropic 5

chr2_-_89521942 0.338 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr2_+_234668894 0.335 ENST00000608383.1
ENST00000360418.3
ENST00000305208.5
UGT1A1

UGT1A8
UDP glucuronosyltransferase 1 family, polypeptide A8

UDP glucuronosyltransferase 1 family, polypeptide A1
chr17_-_61973929 0.333 ENST00000329882.8
ENST00000453363.3
ENST00000316193.8
CSH1


chorionic somatomammotropin hormone 1 (placental lactogen)


chr5_-_148758839 0.331 ENST00000261796.3
IL17B
interleukin 17B
chr7_+_76139741 0.328 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
UPK3B



uroplakin 3B



chr16_+_640201 0.323 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr2_+_171673417 0.322 ENST00000344257.5
GAD1
glutamate decarboxylase 1 (brain, 67kDa)
chr3_-_197024394 0.322 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1




discs, large homolog 1 (Drosophila)




chr1_+_13910757 0.320 ENST00000376061.4
ENST00000513143.1
PDPN

podoplanin

chr2_+_89998789 0.318 ENST00000453166.2
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr1_+_101702417 0.317 ENST00000305352.6
S1PR1
sphingosine-1-phosphate receptor 1
chr7_-_105319536 0.316 ENST00000477775.1
ATXN7L1
ataxin 7-like 1
chr1_+_156785425 0.307 ENST00000392302.2
NTRK1
neurotrophic tyrosine kinase, receptor, type 1
chr12_-_28124903 0.305 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH


parathyroid hormone-like hormone


chr17_-_7297519 0.300 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3

TMEM256-PLSCR3 readthrough (NMD candidate)

chr11_+_119019722 0.297 ENST00000307417.3
ABCG4
ATP-binding cassette, sub-family G (WHITE), member 4
chr17_-_40333099 0.297 ENST00000607371.1
KCNH4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr2_+_204193101 0.296 ENST00000430418.1
ENST00000424558.1
ENST00000261016.6
ABI2


abl-interactor 2


chr9_-_98784042 0.293 ENST00000412122.2
LINC00092
long intergenic non-protein coding RNA 92
chr1_+_168250194 0.291 ENST00000367821.3
TBX19
T-box 19
chr1_+_156254070 0.290 ENST00000405535.2
ENST00000456810.1
TMEM79

transmembrane protein 79

chr19_+_17862274 0.288 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
FCHO1








FCH domain only 1








chr5_-_16738451 0.286 ENST00000274203.9
ENST00000515803.1
MYO10

myosin X

chr3_-_178984759 0.285 ENST00000349697.2
ENST00000497599.1
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr2_+_228337079 0.284 ENST00000409315.1
ENST00000373671.3
ENST00000409171.1
AGFG1


ArfGAP with FG repeats 1


chr15_-_74043816 0.282 ENST00000379822.4
C15orf59
chromosome 15 open reading frame 59
chr3_-_182703688 0.281 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCUN1D1



DCN1, defective in cullin neddylation 1, domain containing 1



chr1_+_202995611 0.281 ENST00000367240.2
PPFIA4
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr15_+_89182178 0.280 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr17_-_7297833 0.279 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3



TMEM256-PLSCR3 readthrough (NMD candidate)



chr1_-_12677714 0.278 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr3_+_133292759 0.277 ENST00000431519.2
CDV3
CDV3 homolog (mouse)
chr13_-_99404875 0.275 ENST00000376503.5
SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr11_-_47470591 0.274 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr17_-_33416231 0.272 ENST00000584655.1
ENST00000447669.2
ENST00000315249.7
RFFL


ring finger and FYVE-like domain containing E3 ubiquitin protein ligase


chr2_+_201676256 0.272 ENST00000452206.1
ENST00000410110.2
ENST00000409600.1
BZW1


basic leucine zipper and W2 domains 1


chr4_-_82136114 0.272 ENST00000395578.1
ENST00000418486.2
PRKG2

protein kinase, cGMP-dependent, type II

chr5_-_54281491 0.271 ENST00000381405.4
ESM1
endothelial cell-specific molecule 1
chr13_-_79177673 0.270 ENST00000377208.5
POU4F1
POU class 4 homeobox 1
chr6_+_167536230 0.269 ENST00000341935.5
ENST00000349984.4
CCR6

chemokine (C-C motif) receptor 6

chr22_+_38201114 0.268 ENST00000340857.2
H1F0
H1 histone family, member 0
chr12_+_50898881 0.267 ENST00000301180.5
DIP2B
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr7_+_2687173 0.266 ENST00000403167.1
TTYH3
tweety family member 3
chrX_+_69642881 0.264 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
GDPD2



glycerophosphodiester phosphodiesterase domain containing 2



chr16_-_29874211 0.263 ENST00000563415.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr11_-_7847519 0.261 ENST00000328375.1
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr11_-_47470703 0.261 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse
chr17_-_39324424 0.261 ENST00000391356.2
KRTAP4-3
keratin associated protein 4-3
chr11_+_1860200 0.261 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr7_+_80231466 0.261 ENST00000309881.7
ENST00000534394.1
CD36

CD36 molecule (thrombospondin receptor)

chr8_+_99439214 0.260 ENST00000287042.4
KCNS2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr4_+_158142750 0.259 ENST00000505888.1
ENST00000449365.1
GRIA2

glutamate receptor, ionotropic, AMPA 2

chr17_-_61959202 0.259 ENST00000449787.2
ENST00000456543.2
ENST00000423893.2
ENST00000332800.7
GH2



growth hormone 2



chr17_-_61996160 0.256 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
GH1


growth hormone 1


chr3_+_35722844 0.256 ENST00000436702.1
ENST00000438071.1
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr3_+_14860469 0.255 ENST00000285046.5
FGD5
FYVE, RhoGEF and PH domain containing 5
chr3_+_38035610 0.254 ENST00000465644.1
VILL
villin-like
chr20_-_22565101 0.251 ENST00000419308.2
FOXA2
forkhead box A2
chr2_-_72374948 0.251 ENST00000546307.1
ENST00000474509.1
CYP26B1

cytochrome P450, family 26, subfamily B, polypeptide 1

chr13_+_28195988 0.250 ENST00000399697.3
ENST00000399696.1
POLR1D

polymerase (RNA) I polypeptide D, 16kDa

chr7_-_76255444 0.250 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr12_-_102872317 0.249 ENST00000424202.2
IGF1
insulin-like growth factor 1 (somatomedin C)
chr7_+_62809239 0.249 ENST00000456890.1
AC006455.1
AC006455.1
chr9_+_129376722 0.248 ENST00000526117.1
ENST00000373474.4
ENST00000355497.5
ENST00000425646.2
ENST00000561065.1
LMX1B




LIM homeobox transcription factor 1, beta




chr4_+_37962018 0.247 ENST00000504686.1
PTTG2
pituitary tumor-transforming 2
chr17_-_15469590 0.245 ENST00000312127.2
CDRT1
CMT duplicated region transcript 1; Uncharacterized protein
chr20_+_23420322 0.244 ENST00000347397.1
CSTL1
cystatin-like 1
chr12_-_49351228 0.242 ENST00000541959.1
ENST00000447318.2
ARF3

ADP-ribosylation factor 3

chr19_-_4302375 0.242 ENST00000600114.1
ENST00000600349.1
ENST00000595645.1
ENST00000301272.2
TMIGD2



transmembrane and immunoglobulin domain containing 2



chr4_+_78079570 0.241 ENST00000509972.1
CCNG2
cyclin G2
chr1_-_42384343 0.240 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr15_+_41099254 0.238 ENST00000570108.1
ENST00000564258.1
ENST00000355341.4
ENST00000336455.5
ZFYVE19



zinc finger, FYVE domain containing 19



chr11_-_2182388 0.237 ENST00000397270.1
ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
INS-IGF2
INS



INS-IGF2 readthrough
insulin



chr6_-_41168920 0.234 ENST00000483722.1
TREML2
triggering receptor expressed on myeloid cells-like 2
chr10_+_133918175 0.232 ENST00000298622.4
JAKMIP3
Janus kinase and microtubule interacting protein 3
chr11_-_72145426 0.232 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
CLPB


ClpB caseinolytic peptidase B homolog (E. coli)


chr1_+_207039154 0.231 ENST00000367096.3
ENST00000391930.2
IL20

interleukin 20

chrX_-_148713440 0.225 ENST00000536359.1
ENST00000316916.8
TMEM185A

transmembrane protein 185A

chr16_+_30007524 0.225 ENST00000567254.1
ENST00000567705.1
INO80E

INO80 complex subunit E

chr6_+_122931366 0.224 ENST00000368452.2
ENST00000368448.1
ENST00000392490.1
PKIB


protein kinase (cAMP-dependent, catalytic) inhibitor beta


chr2_+_201994208 0.223 ENST00000440180.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr7_+_112063192 0.221 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr2_+_29336855 0.221 ENST00000404424.1
CLIP4
CAP-GLY domain containing linker protein family, member 4
chr3_-_120170052 0.217 ENST00000295633.3
FSTL1
follistatin-like 1
chr2_+_11696464 0.216 ENST00000234142.5
GREB1
growth regulation by estrogen in breast cancer 1
chr12_+_81101277 0.216 ENST00000228641.3
MYF6
myogenic factor 6 (herculin)
chr22_+_46481861 0.215 ENST00000360737.3
FLJ27365
hsa-mir-4763
chr17_+_57970469 0.212 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
RPS6KB1



ribosomal protein S6 kinase, 70kDa, polypeptide 1



chr11_-_47470682 0.212 ENST00000529341.1
ENST00000352508.3
RAPSN

receptor-associated protein of the synapse

chr6_+_45389893 0.211 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr1_-_157670647 0.211 ENST00000368184.3
FCRL3
Fc receptor-like 3
chr1_+_1981890 0.209 ENST00000378567.3
ENST00000468310.1
PRKCZ

protein kinase C, zeta

chr19_+_18723660 0.209 ENST00000262817.3
TMEM59L
transmembrane protein 59-like
chrX_-_128788914 0.208 ENST00000429967.1
ENST00000307484.6
APLN

apelin

chr6_-_26018007 0.208 ENST00000244573.3
HIST1H1A
histone cluster 1, H1a
chr3_+_45986511 0.208 ENST00000458629.1
ENST00000457814.1
CXCR6

chemokine (C-X-C motif) receptor 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.1 GO:2001300 lipoxin metabolic process(GO:2001300)
0.3 0.8 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 0.8 GO:0032824 natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) positive regulation of cytolysis in other organism(GO:0051714)
0.2 0.7 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.2 0.7 GO:1904328 regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.2 1.8 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 0.6 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 0.2 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.2 0.7 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.2 0.6 GO:0035627 ceramide transport(GO:0035627)
0.1 2.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.2 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.5 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.1 0.4 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.1 0.8 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.4 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 1.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.6 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.4 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.1 0.8 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 0.1 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 0.4 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.5 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.1 0.4 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.1 0.6 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.7 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.7 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 0.3 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.3 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.3 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.3 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.3 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.3 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.3 GO:0035803 egg coat formation(GO:0035803)
0.1 0.2 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.5 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.4 GO:0032425 positive regulation of mismatch repair(GO:0032425)
0.1 0.3 GO:0021553 olfactory nerve development(GO:0021553)
0.1 0.4 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1 0.2 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.6 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.4 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.6 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.2 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.1 0.2 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.6 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.4 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.3 GO:0070980 biphenyl catabolic process(GO:0070980)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.2 GO:2000870 positive regulation of female gonad development(GO:2000196) regulation of progesterone secretion(GO:2000870)
0.1 0.4 GO:0010193 response to ozone(GO:0010193)
0.1 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.1 0.2 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.4 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 0.5 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.1 0.3 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.3 GO:0042335 cuticle development(GO:0042335)
0.0 1.1 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 0.2 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.0 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.0 0.4 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.3 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.3 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:0006427 histidyl-tRNA aminoacylation(GO:0006427)
0.0 0.2 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.0 0.3 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.0 0.3 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.2 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.4 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.6 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.1 GO:0098838 reduced folate transmembrane transport(GO:0098838)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:0002290 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.1 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.2 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.2 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.2 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.1 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.0 0.6 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0010728 regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0 0.6 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.1 GO:0007439 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.2 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.0 0.2 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.3 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.1 GO:0014826 cellular magnesium ion homeostasis(GO:0010961) vein smooth muscle contraction(GO:0014826)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.2 GO:0071593 T cell activation(GO:0042110) leukocyte aggregation(GO:0070486) T cell aggregation(GO:0070489) lymphocyte aggregation(GO:0071593)
0.0 0.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488) anterior/posterior axon guidance(GO:0033564)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.2 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.0 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.3 GO:0007567 parturition(GO:0007567)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.4 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 0.0 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 1.6 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.1 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.0 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724)
0.0 0.1 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.1 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.2 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.0 GO:0002775 antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0035976 AP1 complex(GO:0035976)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.8 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.4 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 0.6 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.4 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.7 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.0 0.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.7 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.1 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.5 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 2.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.6 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.6 GO:0030425 dendrite(GO:0030425)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.8 GO:0031904 endosome lumen(GO:0031904)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.6 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404)
0.4 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.3 0.8 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.3 0.8 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 0.9 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.2 0.6 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.2 0.8 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.2 0.6 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 0.5 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.8 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.2 GO:0043426 MRF binding(GO:0043426)
0.1 0.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.4 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.5 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 0.4 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 0.3 GO:0005148 prolactin receptor binding(GO:0005148)
0.1 0.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 0.4 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.6 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 0.3 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.1 0.4 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.4 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.7 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.3 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.1 0.8 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.4 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.2 GO:0004917 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.1 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.1 GO:0004821 histidine-tRNA ligase activity(GO:0004821)
0.0 1.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 3.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.1 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.0 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.3 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.7 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 1.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 2.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.0 0.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.1 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.2 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.6 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.6 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.3 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.9 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.6 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 1.1 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.3 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.7 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis