Motif ID: TCF12_ASCL2

Z-value: 0.650

Transcription factors associated with TCF12_ASCL2:

Gene SymbolEntrez IDGene Name
ASCL2 ENSG00000183734.4 ASCL2
TCF12 ENSG00000140262.13 TCF12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ASCL2hg19_v2_chr11_-_2292182_22922120.564.1e-03Click!
TCF12hg19_v2_chr15_+_57511609_575116640.472.2e-02Click!


Activity profile for motif TCF12_ASCL2.

activity profile for motif TCF12_ASCL2


Sorted Z-values histogram for motif TCF12_ASCL2

Sorted Z-values for motif TCF12_ASCL2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF12_ASCL2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39306054 1.865 ENST00000343246.4
 KRTAP4-5
keratin associated protein 4-5
chr10_-_102089729 1.845 ENST00000465680.2
 PKD2L1
polycystic kidney disease 2-like 1
chr4_-_16085314 1.644 ENST00000510224.1
 PROM1
prominin 1
chr6_-_24911195 1.535 ENST00000259698.4
 FAM65B
family with sequence similarity 65, member B
chr17_+_39261584 1.494 ENST00000391415.1
 KRTAP4-9
keratin associated protein 4-9
chr22_-_50970506 1.492 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chr1_-_75139397 1.403 ENST00000326665.5
 C1orf173
chromosome 1 open reading frame 173
chr4_-_16085340 1.182 ENST00000508167.1
 PROM1
prominin 1
chr1_+_18807424 1.177 ENST00000400664.1
 KLHDC7A
kelch domain containing 7A
chr7_-_73184588 1.041 ENST00000395145.2
 CLDN3
claudin 3
chr17_-_39296739 1.040 ENST00000345847.4
 KRTAP4-6
keratin associated protein 4-6
chrX_-_99665262 0.960 ENST00000373034.4
ENST00000255531.7
 PCDH19

protocadherin 19

chr17_-_39316983 0.944 ENST00000390661.3
 KRTAP4-4
keratin associated protein 4-4
chr22_-_36013368 0.923 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
 MB



myoglobin



chr17_+_39405939 0.901 ENST00000334109.2
 KRTAP9-4
keratin associated protein 9-4
chr17_-_39324424 0.833 ENST00000391356.2
 KRTAP4-3
keratin associated protein 4-3
chr2_+_233390863 0.801 ENST00000449596.1
ENST00000543200.1
 CHRND

cholinergic receptor, nicotinic, delta (muscle)

chr22_-_50970566 0.759 ENST00000405135.1
ENST00000401779.1
 ODF3B

outer dense fiber of sperm tails 3B

chr7_-_131241361 0.745 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL



podocalyxin-like



chr10_+_103348031 0.744 ENST00000370151.4
ENST00000370147.1
ENST00000370148.2
 DPCD


deleted in primary ciliary dyskinesia homolog (mouse)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 408 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0042633 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.7 2.8 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.3 1.9 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 1.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4 1.4 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.0 1.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.3 GO:0001895 retina homeostasis(GO:0001895)
0.1 1.0 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.1 0.9 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.9 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.9 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.2 0.8 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.2 0.8 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 0.8 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.1 0.8 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 0.8 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 0.7 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 0.7 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.7 GO:0009804 coumarin metabolic process(GO:0009804)
0.1 0.7 GO:0098535 de novo centriole assembly(GO:0098535)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0045095 keratin filament(GO:0045095)
0.2 2.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 2.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.7 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.7 GO:0071953 elastic fiber(GO:0071953)
0.1 0.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 0.6 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.6 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 224 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0042805 actinin binding(GO:0042805)
0.1 2.3 GO:0008527 taste receptor activity(GO:0008527)
0.1 1.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 1.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.0 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 1.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.9 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.8 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.1 0.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.8 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.8 GO:0015250 water channel activity(GO:0015250)
0.0 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.2 0.7 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.2 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 0.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.1 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 0.0 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.0 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.0 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 1.0 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.0 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 0.9 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.7 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.6 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling