Motif ID: TCF21

Z-value: 1.454


Transcription factors associated with TCF21:

Gene SymbolEntrez IDGene Name
TCF21 ENSG00000118526.6 TCF21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF21hg19_v2_chr6_+_134210243_1342102760.038.9e-01Click!


Activity profile for motif TCF21.

activity profile for motif TCF21


Sorted Z-values histogram for motif TCF21

Sorted Z-values for motif TCF21



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF21

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_205391178 6.659 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr22_+_38071615 5.782 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr17_-_7493390 4.992 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
 SOX15


SRY (sex determining region Y)-box 15


chrX_+_69509927 4.667 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr1_+_171154347 4.523 ENST00000209929.7
ENST00000441535.1
 FMO2

flavin containing monooxygenase 2 (non-functional)

chr7_-_41742697 4.111 ENST00000242208.4
 INHBA
inhibin, beta A
chr20_-_52790055 3.262 ENST00000395955.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr17_+_6347729 3.247 ENST00000572447.1
 FAM64A
family with sequence similarity 64, member A
chr17_+_6347761 3.201 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A




family with sequence similarity 64, member A




chr17_-_43025005 3.143 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
 KIF18B


kinesin family member 18B


chr18_+_21529811 3.078 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr16_-_46655538 2.963 ENST00000303383.3
 SHCBP1
SHC SH2-domain binding protein 1
chr12_-_6960407 2.686 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
 CDCA3



cell division cycle associated 3



chr5_-_59995921 2.644 ENST00000453022.2
ENST00000545085.1
ENST00000265036.5
 DEPDC1B


DEP domain containing 1B


chr20_+_30327063 2.619 ENST00000300403.6
ENST00000340513.4
 TPX2

TPX2, microtubule-associated

chr5_+_68463043 2.610 ENST00000508407.1
ENST00000505500.1
 CCNB1

cyclin B1

chr12_-_52845910 2.539 ENST00000252252.3
 KRT6B
keratin 6B
chr5_+_68462944 2.528 ENST00000506572.1
 CCNB1
cyclin B1
chr11_+_125496619 2.521 ENST00000532669.1
ENST00000278916.3
 CHEK1

checkpoint kinase 1

chr11_+_125496400 2.475 ENST00000524737.1
 CHEK1
checkpoint kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 178 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 9.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
2.5 7.5 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
1.2 7.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
1.2 6.2 GO:0002317 plasma cell differentiation(GO:0002317)
1.7 5.0 GO:0048627 myoblast development(GO:0048627)
0.3 4.7 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.4 4.1 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.7 4.1 GO:0070995 NADPH oxidation(GO:0070995)
0.1 3.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 3.9 GO:0031424 keratinization(GO:0031424)
0.0 3.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 3.7 GO:0030321 transepithelial chloride transport(GO:0030321)
1.1 3.3 GO:0042369 vitamin D catabolic process(GO:0042369)
0.8 3.3 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 3.1 GO:0031581 hemidesmosome assembly(GO:0031581)
1.0 3.0 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 3.0 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.0 2.9 GO:0007015 actin filament organization(GO:0007015)
0.2 2.8 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 2.7 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 9.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.5 7.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 7.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 6.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 6.4 GO:0045095 keratin filament(GO:0045095)
0.0 6.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 4.9 GO:0005811 lipid particle(GO:0005811)
1.4 4.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 3.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.4 3.1 GO:0005610 laminin-5 complex(GO:0005610)
0.3 3.1 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)
0.2 2.6 GO:0043203 axon hillock(GO:0043203)
0.1 2.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.6 GO:0030027 lamellipodium(GO:0030027)
0.6 2.5 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 2.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.3 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.2 GO:0008307 structural constituent of muscle(GO:0008307)
1.1 7.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
1.2 7.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.4 5.8 GO:0030395 lactose binding(GO:0030395)
0.1 4.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.9 4.3 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
1.4 4.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.7 4.0 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 3.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 3.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 3.4 GO:0019894 kinesin binding(GO:0019894)
0.5 3.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 3.2 GO:0042169 SH2 domain binding(GO:0042169)
0.6 3.0 GO:0032810 sterol response element binding(GO:0032810)
0.0 2.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.5 2.6 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 2.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 2.5 GO:0035174 histone serine kinase activity(GO:0035174)
0.2 2.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.6 PID_PLK1_PATHWAY PLK1 signaling events
0.5 7.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 1.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.2 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.0 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.8 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 14.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 12.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 7.2 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.4 5.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 5.0 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.1 4.7 REACTOME_KINESINS Genes involved in Kinesins
0.2 4.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 3.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 3.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.1 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 3.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 2.3 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 2.3 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.9 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.5 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins