Motif ID: TCF3_MYOG

Z-value: 1.110

Transcription factors associated with TCF3_MYOG:

Gene SymbolEntrez IDGene Name
MYOG ENSG00000122180.4 MYOG
TCF3 ENSG00000071564.10 TCF3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF3hg19_v2_chr19_-_1650666_16507440.803.2e-06Click!
MYOGhg19_v2_chr1_-_203055129_203055164-0.058.3e-01Click!


Activity profile for motif TCF3_MYOG.

activity profile for motif TCF3_MYOG


Sorted Z-values histogram for motif TCF3_MYOG

Sorted Z-values for motif TCF3_MYOG



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF3_MYOG

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_38071615 10.462 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr22_+_31489344 6.860 ENST00000404574.1
 SMTN
smoothelin
chr17_+_39382900 6.465 ENST00000377721.3
ENST00000455970.2
 KRTAP9-2

keratin associated protein 9-2

chr10_-_103347883 5.477 ENST00000339310.3
ENST00000370158.3
ENST00000299206.4
ENST00000456836.2
ENST00000413344.1
ENST00000429502.1
ENST00000430045.1
ENST00000370172.1
ENST00000436284.2
ENST00000370162.3
 POLL









polymerase (DNA directed), lambda









chr22_-_37823468 5.097 ENST00000402918.2
 ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr21_+_30502806 5.055 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL

MAP3K7 C-terminal like

chr17_-_39274606 4.879 ENST00000391413.2
 KRTAP4-11
keratin associated protein 4-11
chr20_+_3776936 4.281 ENST00000439880.2
 CDC25B
cell division cycle 25B
chr11_-_1643368 3.895 ENST00000399682.1
 KRTAP5-4
keratin associated protein 5-4
chr11_+_71249071 3.885 ENST00000398534.3
 KRTAP5-8
keratin associated protein 5-8
chr17_-_39254391 3.680 ENST00000333822.4
 KRTAP4-8
keratin associated protein 4-8
chr19_-_19051103 3.228 ENST00000542541.2
ENST00000433218.2
 HOMER3

homer homolog 3 (Drosophila)

chr11_-_66725837 3.164 ENST00000393958.2
ENST00000393960.1
ENST00000524491.1
ENST00000355677.3
 PC



pyruvate carboxylase



chr9_-_35689900 3.091 ENST00000378300.5
ENST00000329305.2
ENST00000360958.2
 TPM2


tropomyosin 2 (beta)


chr1_-_205391178 3.078 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
 LEMD1



LEM domain containing 1



chr19_+_16187085 2.923 ENST00000300933.4
 TPM4
tropomyosin 4
chr4_-_80994210 2.855 ENST00000403729.2
 ANTXR2
anthrax toxin receptor 2
chr8_+_126010783 2.806 ENST00000521232.1
 SQLE
squalene epoxidase
chr15_-_90039805 2.775 ENST00000544600.1
ENST00000268122.4
 RHCG

Rh family, C glycoprotein

chr17_+_39411636 2.758 ENST00000394008.1
 KRTAP9-9
keratin associated protein 9-9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 403 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 32.7 GO:0031424 keratinization(GO:0031424)
0.1 13.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
2.1 10.5 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 9.2 GO:0030308 negative regulation of cell growth(GO:0030308)
0.1 8.3 GO:1901998 toxin transport(GO:1901998)
0.1 7.9 GO:0006939 smooth muscle contraction(GO:0006939)
0.6 6.8 GO:0007144 female meiosis I(GO:0007144)
0.9 5.5 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 5.1 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.2 4.3 GO:0070831 basement membrane assembly(GO:0070831)
0.6 3.9 GO:0007296 vitellogenesis(GO:0007296)
0.4 3.8 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 3.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.4 3.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.9 3.5 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 3.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 3.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
1.1 3.2 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1 3.2 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 3.0 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 28.1 GO:0045095 keratin filament(GO:0045095)
0.0 13.7 GO:0030027 lamellipodium(GO:0030027)
0.5 9.4 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 9.3 GO:0000922 spindle pole(GO:0000922)
0.0 8.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 8.7 GO:0005925 focal adhesion(GO:0005925)
0.0 7.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 6.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 5.2 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.1 GO:0005882 intermediate filament(GO:0005882)
0.1 3.9 GO:0030673 axolemma(GO:0030673)
0.0 3.9 GO:0005901 caveola(GO:0005901)
0.1 3.5 GO:0043034 costamere(GO:0043034)
0.0 3.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 3.5 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 3.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 3.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 3.0 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.4 GO:0045180 basal cortex(GO:0045180)
0.0 2.3 GO:0005905 clathrin-coated pit(GO:0005905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 255 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 GO:0008307 structural constituent of muscle(GO:0008307)
2.6 10.5 GO:0030395 lactose binding(GO:0030395)
0.1 8.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 7.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 6.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 6.2 GO:0005525 GTP binding(GO:0005525)
0.1 5.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.5 5.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 5.2 GO:0003823 antigen binding(GO:0003823)
0.0 4.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 4.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 4.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 3.8 GO:0043422 protein kinase B binding(GO:0043422)
0.1 3.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.4 3.6 GO:0043426 MRF binding(GO:0043426)
0.7 3.4 GO:0050436 microfibril binding(GO:0050436)
0.1 3.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 3.2 GO:0031014 troponin T binding(GO:0031014)
0.2 3.2 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.3 3.0 GO:0004075 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 9.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 8.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.5 6.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 6.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 5.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.3 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.6 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 6.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 5.6 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 5.1 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 3.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 3.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 3.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.0 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 2.8 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.6 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 2.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.1 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions