Motif ID: TCF7

Z-value: 0.681


Transcription factors associated with TCF7:

Gene SymbolEntrez IDGene Name
TCF7 ENSG00000081059.15 TCF7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7hg19_v2_chr5_+_133450365_1334504440.602.2e-03Click!


Activity profile for motif TCF7.

activity profile for motif TCF7


Sorted Z-values histogram for motif TCF7

Sorted Z-values for motif TCF7



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_116937636 1.936 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
 RSPH4A


radial spoke head 4 homolog A (Chlamydomonas)


chr17_+_68100989 1.882 ENST00000585558.1
ENST00000392670.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr10_-_61513201 1.768 ENST00000414264.1
ENST00000594536.1
 LINC00948

long intergenic non-protein coding RNA 948

chr7_-_154863264 1.686 ENST00000395731.2
ENST00000543018.1
 HTR5A-AS1

HTR5A antisense RNA 1

chr6_+_112408768 1.467 ENST00000368656.2
ENST00000604268.1
 FAM229B

family with sequence similarity 229, member B

chr20_+_31823792 1.440 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
 BPIFA1


BPI fold containing family A, member 1


chr2_-_86564776 1.436 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
 REEP1


receptor accessory protein 1


chr14_+_74486043 1.369 ENST00000464394.1
ENST00000394009.3
 CCDC176

coiled-coil domain containing 176

chr12_-_58329819 1.272 ENST00000551421.1
 RP11-620J15.3
RP11-620J15.3
chr3_-_197676740 1.270 ENST00000452735.1
ENST00000453254.1
ENST00000455191.1
 IQCG


IQ motif containing G


chr6_-_29527702 1.256 ENST00000377050.4
 UBD
ubiquitin D
chr17_-_63556414 1.255 ENST00000585045.1
 AXIN2
axin 2
chr17_-_63557309 1.227 ENST00000580513.1
 AXIN2
axin 2
chr2_+_172378757 1.224 ENST00000409484.1
ENST00000321348.4
ENST00000375252.3
 CYBRD1


cytochrome b reductase 1


chr11_-_8615507 1.155 ENST00000431279.2
ENST00000418597.1
 STK33

serine/threonine kinase 33

chr1_-_151345159 0.973 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
 SELENBP1




selenium binding protein 1




chr12_-_58329888 0.955 ENST00000546580.1
 RP11-620J15.3
RP11-620J15.3
chr7_+_142829162 0.928 ENST00000291009.3
 PIP
prolactin-induced protein
chr20_-_39317868 0.870 ENST00000373313.2
 MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr1_+_183774240 0.846 ENST00000360851.3
 RGL1
ral guanine nucleotide dissociation stimulator-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 2.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.4 2.2 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0 2.1 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.9 GO:0035082 axoneme assembly(GO:0035082)
0.1 1.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.3 1.3 GO:0070842 aggresome assembly(GO:0070842)
0.1 1.3 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 1.2 GO:0010107 potassium ion import(GO:0010107)
0.0 1.2 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.3 0.9 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.9 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 0.8 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.7 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.7 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.6 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.6 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 0.5 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.6 1.9 GO:0001534 radial spoke(GO:0001534)
0.0 1.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 1.3 GO:0002177 manchette(GO:0002177)
0.0 1.2 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.8 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.8 GO:0031526 brush border membrane(GO:0031526)
0.1 0.5 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 0.5 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.3 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 1.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 1.3 GO:0070628 proteasome binding(GO:0070628)
0.1 1.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 1.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 1.0 GO:0008430 selenium binding(GO:0008430)
0.1 0.9 GO:0019864 IgG binding(GO:0019864)
0.1 0.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1 0.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.7 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.6 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.5 GO:0045545 syndecan binding(GO:0045545)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.4 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 0.4 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 0.4 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.4 GO:0004565 beta-galactosidase activity(GO:0004565)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.1 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.7 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.3 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide