Motif ID: TCF7L2

Z-value: 0.446


Transcription factors associated with TCF7L2:

Gene SymbolEntrez IDGene Name
TCF7L2 ENSG00000148737.11 TCF7L2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114710516_1147106750.368.4e-02Click!


Activity profile for motif TCF7L2.

activity profile for motif TCF7L2


Sorted Z-values histogram for motif TCF7L2

Sorted Z-values for motif TCF7L2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF7L2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_63557309 1.362 ENST00000580513.1
 AXIN2
axin 2
chr17_-_63556414 1.286 ENST00000585045.1
 AXIN2
axin 2
chr13_+_24144509 1.260 ENST00000248484.4
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_+_24144796 0.947 ENST00000403372.2
 TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr13_-_36429763 0.751 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr17_+_68100989 0.665 ENST00000585558.1
ENST00000392670.1
 KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr17_-_63557759 0.665 ENST00000307078.5
 AXIN2
axin 2
chr3_-_45957088 0.611 ENST00000539217.1
 LZTFL1
leucine zipper transcription factor-like 1
chr1_+_61330931 0.572 ENST00000371191.1
 NFIA
nuclear factor I/A
chr1_+_162351503 0.533 ENST00000458626.2
 C1orf226
chromosome 1 open reading frame 226
chr20_+_18794370 0.527 ENST00000377428.2
 SCP2D1
SCP2 sterol-binding domain containing 1
chr3_-_45957534 0.516 ENST00000536047.1
 LZTFL1
leucine zipper transcription factor-like 1
chr2_+_204801471 0.516 ENST00000316386.6
ENST00000435193.1
 ICOS

inducible T-cell co-stimulator

chr17_-_39165366 0.470 ENST00000391588.1
 KRTAP3-1
keratin associated protein 3-1
chr12_-_49582978 0.447 ENST00000301071.7
 TUBA1A
tubulin, alpha 1a
chr10_+_114133773 0.421 ENST00000354655.4
 ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_123542224 0.377 ENST00000264497.3
 IL21
interleukin 21
chr15_-_93632421 0.367 ENST00000329082.7
 RGMA
repulsive guidance molecule family member a
chr2_+_69240302 0.350 ENST00000303714.4
 ANTXR1
anthrax toxin receptor 1
chr10_+_7745232 0.347 ENST00000358415.4
 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.3 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 1.9 GO:0001942 hair follicle development(GO:0001942)
0.4 1.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.8 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.2 0.7 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 0.6 GO:0072189 ureter development(GO:0072189)
0.0 0.5 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 0.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.3 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.2 GO:0060086 circadian temperature homeostasis(GO:0060086) positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)

Gene overrepresentation in cellular_component category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.1 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 GO:0070411 I-SMAD binding(GO:0070411)
0.1 2.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.3 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.2 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.0 0.1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection