Motif ID: TEAD3_TEAD1

Z-value: 1.066

Transcription factors associated with TEAD3_TEAD1:

Gene SymbolEntrez IDGene Name
TEAD1 ENSG00000187079.10 TEAD1
TEAD3 ENSG00000007866.14 TEAD3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TEAD3hg19_v2_chr6_-_35464727_35464738,
hg19_v2_chr6_-_35464817_35464894		0.529.5e-03Click!
TEAD1hg19_v2_chr11_+_12695944_126959890.443.0e-02Click!


Activity profile for motif TEAD3_TEAD1.

activity profile for motif TEAD3_TEAD1


Sorted Z-values histogram for motif TEAD3_TEAD1

Sorted Z-values for motif TEAD3_TEAD1



Network of associatons between targets according to the STRING database.



First level regulatory network of TEAD3_TEAD1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51472031 6.455 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51472222 6.139 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr10_-_90712520 4.352 ENST00000224784.6
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr9_-_139891165 3.831 ENST00000494426.1
 CLIC3
chloride intracellular channel 3
chr15_+_39873268 2.969 ENST00000397591.2
ENST00000260356.5
 THBS1

thrombospondin 1

chr19_-_51512804 2.456 ENST00000594211.1
ENST00000376832.4
 KLK9

kallikrein-related peptidase 9

chr19_-_51504411 2.201 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr7_+_134464376 2.196 ENST00000454108.1
ENST00000361675.2
 CALD1

caldesmon 1

chr7_+_134464414 2.191 ENST00000361901.2
 CALD1
caldesmon 1
chr19_+_45409011 2.164 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
 APOE


apolipoprotein E


chr17_-_40575535 2.088 ENST00000357037.5
 PTRF
polymerase I and transcript release factor
chr10_-_17659234 2.073 ENST00000466335.1
 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr1_+_183155373 1.983 ENST00000493293.1
ENST00000264144.4
 LAMC2

laminin, gamma 2

chr12_-_54813229 1.943 ENST00000293379.4
 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_+_70117153 1.943 ENST00000245479.2
 SOX9
SRY (sex determining region Y)-box 9
chr1_+_86046433 1.934 ENST00000451137.2
 CYR61
cysteine-rich, angiogenic inducer, 61
chr14_-_57272366 1.910 ENST00000554788.1
ENST00000554845.1
ENST00000408990.3
 OTX2


orthodenticle homeobox 2


chr11_-_62313090 1.897 ENST00000528508.1
ENST00000533365.1
 AHNAK

AHNAK nucleoprotein

chr15_+_63334831 1.857 ENST00000288398.6
ENST00000358278.3
ENST00000560445.1
ENST00000403994.3
ENST00000357980.4
ENST00000559556.1
ENST00000559397.1
ENST00000267996.7
ENST00000560970.1
 TPM1








tropomyosin 1 (alpha)








chr2_-_216257849 1.854 ENST00000456923.1
 FN1
fibronectin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 204 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.6 GO:0016540 protein autoprocessing(GO:0016540)
0.8 4.7 GO:0090131 mesenchyme migration(GO:0090131)
0.2 4.3 GO:0007021 tubulin complex assembly(GO:0007021)
0.3 4.1 GO:0035878 nail development(GO:0035878)
0.5 3.6 GO:0031642 negative regulation of myelination(GO:0031642)
0.1 3.4 GO:0097435 fibril organization(GO:0097435)
0.0 3.2 GO:0006749 glutathione metabolic process(GO:0006749)
1.0 3.0 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.4 2.9 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 2.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.8 2.3 GO:0060516 primary prostatic bud elongation(GO:0060516)
0.1 2.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.7 2.2 GO:2000646 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646)
0.1 2.1 GO:0050884 neuromuscular process controlling posture(GO:0050884)
0.1 2.1 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 2.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.6 1.9 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.6 1.9 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.2 1.9 GO:2000543 positive regulation of gastrulation(GO:2000543)
0.2 1.9 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.2 GO:0030141 secretory granule(GO:0030141)
0.4 5.9 GO:0030478 actin cap(GO:0030478)
0.0 5.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 4.7 GO:0005577 fibrinogen complex(GO:0005577)
0.7 4.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 4.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 4.1 GO:0034707 chloride channel complex(GO:0034707)
0.2 3.9 GO:0097512 cardiac myofibril(GO:0097512)
0.2 3.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 3.1 GO:0030018 Z disc(GO:0030018)
0.2 2.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059)
0.7 2.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 2.2 GO:0016605 PML body(GO:0016605)
0.2 2.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.1 GO:0043034 costamere(GO:0043034)
0.0 2.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.7 2.0 GO:0005607 laminin-2 complex(GO:0005607)
0.5 1.9 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.5 1.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 148 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 6.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 5.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 4.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 3.1 GO:0038132 neuregulin binding(GO:0038132)
1.0 3.0 GO:0070052 collagen V binding(GO:0070052)
0.0 2.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 2.3 GO:0002162 dystroglycan binding(GO:0002162)
0.5 2.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 2.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 2.0 GO:0008201 heparin binding(GO:0008201)
0.1 2.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.6 1.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 1.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 1.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.9 GO:0016504 peptidase activator activity(GO:0016504)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 8.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.3 6.4 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 4.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 3.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 10.1 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 3.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.2 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 2.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.9 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.6 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 1.6 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions