Motif ID: TFAP2C

Z-value: 0.851


Transcription factors associated with TFAP2C:

Gene SymbolEntrez IDGene Name
TFAP2C ENSG00000087510.5 TFAP2C

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFAP2Chg19_v2_chr20_+_55204351_55204377-0.433.8e-02Click!


Activity profile for motif TFAP2C.

activity profile for motif TFAP2C


Sorted Z-values histogram for motif TFAP2C

Sorted Z-values for motif TFAP2C



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2C

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51487282 2.101 ENST00000595820.1
ENST00000597707.1
ENST00000336317.4
 KLK7


kallikrein-related peptidase 7


chr19_-_51487071 1.879 ENST00000391807.1
ENST00000593904.1
 KLK7

kallikrein-related peptidase 7

chr13_-_20806440 1.808 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr19_+_35645817 1.711 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr10_-_5541525 1.578 ENST00000380332.3
 CALML5
calmodulin-like 5
chr4_-_57522673 1.552 ENST00000381255.3
ENST00000317745.7
ENST00000555760.2
ENST00000556614.2
 HOPX



HOP homeobox



chr1_-_153521597 1.468 ENST00000368712.1
 S100A3
S100 calcium binding protein A3
chr6_+_151561506 1.464 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_153521714 1.453 ENST00000368713.3
 S100A3
S100 calcium binding protein A3
chr22_+_38071615 1.449 ENST00000215909.5
 LGALS1
lectin, galactoside-binding, soluble, 1
chr12_+_53491220 1.440 ENST00000548547.1
ENST00000301464.3
 IGFBP6

insulin-like growth factor binding protein 6

chr4_-_57522598 1.431 ENST00000553379.2
 HOPX
HOP homeobox
chr18_-_28681950 1.400 ENST00000251081.6
 DSC2
desmocollin 2
chr19_+_8429031 1.374 ENST00000301455.2
ENST00000541807.1
ENST00000393962.2
 ANGPTL4


angiopoietin-like 4


chr9_+_131182697 1.358 ENST00000372838.4
ENST00000411852.1
 CERCAM

cerebral endothelial cell adhesion molecule

chr10_+_95256356 1.344 ENST00000371485.3
 CEP55
centrosomal protein 55kDa
chr19_-_51512804 1.232 ENST00000594211.1
ENST00000376832.4
 KLK9

kallikrein-related peptidase 9

chr19_+_35645618 1.220 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr2_-_241396131 1.201 ENST00000404327.3
 AC110619.2
Uncharacterized protein
chr9_+_139553306 1.187 ENST00000371699.1
 EGFL7
EGF-like-domain, multiple 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 710 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.6 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 3.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.0 2.9 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.1 2.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.3 2.8 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 2.6 GO:0070268 cornification(GO:0070268)
0.2 2.4 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.3 2.2 GO:0035900 response to isolation stress(GO:0035900)
0.1 2.2 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.5 2.1 GO:0033123 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.2 2.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 2.1 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 2.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 2.0 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 2.0 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.6 1.9 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.6 1.8 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.1 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.6 1.7 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 1.7 GO:2000252 negative regulation of feeding behavior(GO:2000252)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 232 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.9 6.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 6.3 GO:0005882 intermediate filament(GO:0005882)
0.0 6.2 GO:0030027 lamellipodium(GO:0030027)
0.0 4.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 3.0 GO:0030057 desmosome(GO:0030057)
0.0 2.9 GO:0005901 caveola(GO:0005901)
0.0 2.9 GO:0001726 ruffle(GO:0001726)
0.3 2.3 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.1 2.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.1 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 2.0 GO:0005922 connexon complex(GO:0005922)
0.1 2.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.4 1.8 GO:0032449 CBM complex(GO:0032449)
0.2 1.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.2 1.7 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 1.7 GO:0044291 cell-cell contact zone(GO:0044291)
0.5 1.5 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 436 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.2 GO:0005096 GTPase activator activity(GO:0005096)
0.2 3.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 3.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.9 GO:0019887 protein kinase regulator activity(GO:0019887)
0.3 2.8 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 2.8 GO:0005178 integrin binding(GO:0005178)
0.1 2.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.2 GO:0050699 WW domain binding(GO:0050699)
0.2 2.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 2.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 2.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 1.9 GO:0017166 vinculin binding(GO:0017166)
0.1 1.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.8 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.3 1.7 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.7 GO:0033691 sialic acid binding(GO:0033691)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 6.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 4.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 4.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.8 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 2.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 2.2 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.2 PID_FOXO_PATHWAY FoxO family signaling
0.1 2.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 1.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.4 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.4 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 3.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 2.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 2.1 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 2.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 1.7 REACTOME_G1_PHASE Genes involved in G1 Phase