Motif ID: TFCP2

Z-value: 0.826


Transcription factors associated with TFCP2:

Gene SymbolEntrez IDGene Name
TFCP2 ENSG00000135457.5 TFCP2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFCP2hg19_v2_chr12_-_51566849_51566927-0.301.5e-01Click!


Activity profile for motif TFCP2.

activity profile for motif TFCP2


Sorted Z-values histogram for motif TFCP2

Sorted Z-values for motif TFCP2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFCP2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_113542063 2.171 ENST00000263339.3
 IL1A
interleukin 1, alpha
chr4_-_80994619 1.915 ENST00000404191.1
 ANTXR2
anthrax toxin receptor 2
chr5_-_149669192 1.834 ENST00000398376.3
 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr14_+_75746781 1.702 ENST00000555347.1
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr5_-_39219705 1.387 ENST00000351578.6
 FYB
FYN binding protein
chr5_-_39219641 1.210 ENST00000509072.1
ENST00000504542.1
ENST00000505428.1
ENST00000506557.1
 FYB



FYN binding protein



chr20_-_5591626 1.209 ENST00000379019.4
 GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr1_+_45212074 1.143 ENST00000372217.1
 KIF2C
kinesin family member 2C
chr11_+_62649158 1.093 ENST00000539891.1
ENST00000536981.1
 SLC3A2

solute carrier family 3 (amino acid transporter heavy chain), member 2

chr10_-_90611566 1.017 ENST00000371930.4
 ANKRD22
ankyrin repeat domain 22
chr1_+_45212051 1.015 ENST00000372222.3
 KIF2C
kinesin family member 2C
chr10_+_88718314 0.996 ENST00000348795.4
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr12_+_41086297 0.922 ENST00000551295.2
 CNTN1
contactin 1
chr4_-_174255400 0.881 ENST00000506267.1
 HMGB2
high mobility group box 2
chr5_+_137514687 0.871 ENST00000394894.3
 KIF20A
kinesin family member 20A
chr6_+_31371337 0.858 ENST00000449934.2
ENST00000421350.1
 MICA

MHC class I polypeptide-related sequence A

chr5_+_137514834 0.839 ENST00000508792.1
ENST00000504621.1
 KIF20A

kinesin family member 20A

chr18_-_67873078 0.830 ENST00000255674.6
 RTTN
rotatin
chr10_-_33625154 0.805 ENST00000265371.4
 NRP1
neuropilin 1
chr11_-_28129656 0.797 ENST00000263181.6
 KIF18A
kinesin family member 18A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.4 2.2 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.2 2.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 2.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 2.1 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.2 2.0 GO:2000111 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 2.0 GO:1901998 toxin transport(GO:1901998)
0.2 1.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 1.7 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.3 1.6 GO:0030421 defecation(GO:0030421)
0.2 1.6 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.0 1.5 GO:0032570 response to progesterone(GO:0032570)
0.4 1.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.2 1.4 GO:0046618 drug export(GO:0046618)
0.0 1.4 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 1.3 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.1 1.3 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 1.2 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.1 1.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.1 GO:0001923 B-1 B cell differentiation(GO:0001923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.8 GO:0005795 Golgi stack(GO:0005795)
0.1 2.2 GO:0035371 microtubule plus-end(GO:0035371)
0.2 2.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 1.7 GO:0035976 AP1 complex(GO:0035976)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)
0.0 1.6 GO:0036064 ciliary basal body(GO:0036064)
0.2 1.5 GO:0036128 CatSper complex(GO:0036128)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.8 GO:0097443 sorting endosome(GO:0097443)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.0 0.7 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.6 GO:0031298 replication fork protection complex(GO:0031298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 2.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 2.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 1.7 GO:0070412 R-SMAD binding(GO:0070412)
0.2 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.4 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.1 1.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 1.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.2 1.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 1.3 GO:0043621 protein self-association(GO:0043621)
0.4 1.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 1.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.8 GO:0047718 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.1 0.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.8 GO:0004568 chitinase activity(GO:0004568)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 2.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.0 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 1.9 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.1 1.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.7 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.5 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.8 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.8 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.8 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.8 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.0 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 2.2 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 2.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.8 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.8 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.4 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.4 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.2 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.1 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 1.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.9 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.6 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1