Motif ID: TFEC_MITF_ARNTL_BHLHE41
Z-value: 0.660
Transcription factors associated with TFEC_MITF_ARNTL_BHLHE41:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ARNTL | ENSG00000133794.13 | ARNTL |
| BHLHE41 | ENSG00000123095.5 | BHLHE41 |
| MITF | ENSG00000187098.10 | MITF |
| TFEC | ENSG00000105967.11 | TFEC |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BHLHE41 | hg19_v2_chr12_-_26278030_26278060 | 0.43 | 3.8e-02 | Click! |
| MITF | hg19_v2_chr3_+_69985792_69985874 | -0.33 | 1.2e-01 | Click! |
| ARNTL | hg19_v2_chr11_+_13299186_13299432 | -0.26 | 2.1e-01 | Click! |
| TFEC | hg19_v2_chr7_-_115670804_115670867, hg19_v2_chr7_-_115608304_115608352 | -0.02 | 9.4e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 153 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.4 | 2.6 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.0 | 2.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 1.5 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.2 | 1.3 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.4 | 1.2 | GO:1904170 | regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172) |
| 0.3 | 1.1 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.2 | 1.0 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.1 | 1.0 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 1.0 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.2 | 0.9 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 0.0 | 0.8 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.0 | 0.8 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 0.8 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.0 | 0.8 | GO:0050775 | positive regulation of dendrite morphogenesis(GO:0050775) |
| 0.2 | 0.6 | GO:0009436 | glyoxylate catabolic process(GO:0009436) |
| 0.2 | 0.6 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 0.2 | 0.6 | GO:0043311 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.2 | 0.6 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.1 | 0.6 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production(GO:0071638) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 60 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 2.5 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.3 | 2.3 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 2.1 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.2 | 1.2 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 1.0 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 0.8 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 0.6 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.6 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.1 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 0.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.5 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.5 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.4 | GO:0001534 | radial spoke(GO:0001534) |
| 0.1 | 0.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.4 | GO:0097228 | sperm principal piece(GO:0097228) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 94 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 2.5 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.4 | 2.4 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.0 | 1.6 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 1.1 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.0 | 1.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 1.0 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.0 | 1.0 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 0.8 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 0.8 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.2 | 0.7 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.0 | 0.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.7 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 0.6 | GO:0070361 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 0.2 | 0.6 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.2 | 0.6 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.1 | 0.6 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.0 | 0.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in C2:CP category:
Showing 1 to 11 of 11 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 1.1 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 1.1 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 1.0 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.9 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.6 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.6 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.1 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.1 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 19 of 19 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.3 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 1.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.0 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.9 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 0.9 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.7 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.6 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 0.4 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 0.4 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 0.3 | REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.3 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.1 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.0 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
|
|
|