Motif ID: THRA_RXRB

Z-value: 0.703

Transcription factors associated with THRA_RXRB:

Gene SymbolEntrez IDGene Name
RXRB ENSG00000204231.6 RXRB
THRA ENSG00000126351.8 THRA

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
THRAhg19_v2_chr17_+_38219063_38219154-0.664.8e-04Click!
RXRBhg19_v2_chr6_-_33168391_33168465-0.368.3e-02Click!


Activity profile for motif THRA_RXRB.

activity profile for motif THRA_RXRB


Sorted Z-values histogram for motif THRA_RXRB

Sorted Z-values for motif THRA_RXRB



Network of associatons between targets according to the STRING database.



First level regulatory network of THRA_RXRB

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_162887556 2.608 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
 HMMR


hyaluronan-mediated motility receptor (RHAMM)


chr1_+_152881014 1.823 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr10_+_11784360 1.609 ENST00000379215.4
ENST00000420401.1
 ECHDC3

enoyl CoA hydratase domain containing 3

chr10_+_77056134 1.583 ENST00000528121.1
ENST00000416398.1
 ZNF503-AS1

ZNF503 antisense RNA 1

chr19_+_54371114 1.503 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
 MYADM



myeloid-associated differentiation marker



chr15_-_34629922 1.469 ENST00000559484.1
ENST00000354181.3
ENST00000558589.1
ENST00000458406.2
 SLC12A6



solute carrier family 12 (potassium/chloride transporter), member 6



chr15_-_75017711 1.407 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
 CYP1A1





cytochrome P450, family 1, subfamily A, polypeptide 1





chr15_-_34630234 1.229 ENST00000558667.1
ENST00000561120.1
ENST00000559236.1
ENST00000397702.2
 SLC12A6



solute carrier family 12 (potassium/chloride transporter), member 6



chr2_+_220491973 1.197 ENST00000358055.3
 SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr9_+_125133315 1.190 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr1_-_150693318 1.181 ENST00000442853.1
ENST00000368995.4
ENST00000368993.2
ENST00000361824.2
ENST00000322343.7
 HORMAD1




HORMA domain containing 1




chr1_+_45212074 1.154 ENST00000372217.1
 KIF2C
kinesin family member 2C
chr1_+_45212051 1.151 ENST00000372222.3
 KIF2C
kinesin family member 2C
chr3_-_50340996 1.119 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr12_-_25102252 1.062 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr1_+_17531614 1.035 ENST00000375471.4
 PADI1
peptidyl arginine deiminase, type I
chr9_+_36572851 0.994 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
 MELK







maternal embryonic leucine zipper kinase







chr12_-_95510743 0.985 ENST00000551521.1
 FGD6
FYVE, RhoGEF and PH domain containing 6
chr22_-_29138386 0.948 ENST00000544772.1
 CHEK2
checkpoint kinase 2
chr9_+_116298778 0.939 ENST00000462143.1
 RGS3
regulator of G-protein signaling 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 2.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 2.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 2.2 GO:0015701 bicarbonate transport(GO:0015701)
0.6 1.8 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.6 1.8 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 1.6 GO:0006734 NADH metabolic process(GO:0006734)
0.4 1.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.5 1.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.1 1.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.4 1.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138) meiotic recombination checkpoint(GO:0051598)
0.1 1.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 1.2 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.3 1.1 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.2 1.1 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 1.1 GO:0007144 female meiosis I(GO:0007144)
0.0 1.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.0 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.0 GO:0046847 filopodium assembly(GO:0046847)
0.1 0.9 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.9 GO:0016605 PML body(GO:0016605)
0.0 1.8 GO:0001533 cornified envelope(GO:0001533)
0.0 1.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.2 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 1.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.7 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.7 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.6 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.5 GO:0005826 actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 2.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 2.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 2.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.5 1.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 1.4 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.3 1.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2 1.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 1.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.8 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.8 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.7 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 PID_ATM_PATHWAY ATM pathway
0.0 2.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 2.3 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.4 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.1 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 0.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants