Motif ID: THRB

Z-value: 0.303


Transcription factors associated with THRB:

Gene SymbolEntrez IDGene Name
THRB ENSG00000151090.13 THRB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24207039_242070860.262.2e-01Click!


Activity profile for motif THRB.

activity profile for motif THRB


Sorted Z-values histogram for motif THRB

Sorted Z-values for motif THRB



Network of associatons between targets according to the STRING database.



First level regulatory network of THRB

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 48 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_101084446 0.685 ENST00000538112.2
ENST00000559639.1
ENST00000558884.2
CERS3


ceramide synthase 3


chr11_+_5617976 0.632 ENST00000445329.1
TRIM6
tripartite motif containing 6
chr11_+_5617858 0.611 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr13_-_24007815 0.536 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr15_-_101084547 0.533 ENST00000394113.1
CERS3
ceramide synthase 3
chr1_-_113498943 0.522 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr1_-_113498616 0.511 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr17_-_73840415 0.362 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D


unc-13 homolog D (C. elegans)


chr10_+_62538089 0.327 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1


cyclin-dependent kinase 1


chr10_+_62538248 0.291 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr15_-_101084881 0.289 ENST00000284382.4
CERS3
ceramide synthase 3
chr3_+_50606901 0.269 ENST00000455834.1
HEMK1
HemK methyltransferase family member 1
chr8_-_124037890 0.268 ENST00000519018.1
ENST00000523036.1
DERL1

derlin 1

chr3_+_50606577 0.245 ENST00000434410.1
ENST00000232854.4
HEMK1

HemK methyltransferase family member 1

chr15_-_35838348 0.241 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
DPH6


diphthamine biosynthesis 6


chr6_-_99842041 0.235 ENST00000254759.3
ENST00000369242.1
COQ3

coenzyme Q3 methyltransferase

chr2_-_9563469 0.186 ENST00000484735.1
ENST00000456913.2
ITGB1BP1

integrin beta 1 binding protein 1

chr18_-_47807829 0.167 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
MBD1




methyl-CpG binding domain protein 1




chr11_-_64014379 0.132 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr22_+_19938419 0.132 ENST00000412786.1
COMT
catechol-O-methyltransferase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 1.2 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.3 1.0 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.6 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.5 GO:0043320 natural killer cell degranulation(GO:0043320)
0.0 0.5 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.3 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.1 GO:0050668 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0002290 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)

Gene overrepresentation in cellular_component category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.6 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.3 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)

Gene overrepresentation in molecular_function category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.2 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.3 1.0 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.5 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 0.3 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade