Motif ID: TLX1_NFIC

Z-value: 1.191

Transcription factors associated with TLX1_NFIC:

Gene SymbolEntrez IDGene Name
NFIC ENSG00000141905.13 NFIC
TLX1 ENSG00000107807.8 TLX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX1hg19_v2_chr10_+_102891048_1028910780.331.1e-01Click!
NFIChg19_v2_chr19_+_3359561_3359681-0.058.2e-01Click!


Activity profile for motif TLX1_NFIC.

activity profile for motif TLX1_NFIC


Sorted Z-values histogram for motif TLX1_NFIC

Sorted Z-values for motif TLX1_NFIC



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1_NFIC

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_74372662 2.896 ENST00000591651.1
ENST00000545180.1
 SPHK1

sphingosine kinase 1

chr18_+_21529811 2.552 ENST00000588004.1
 LAMA3
laminin, alpha 3
chr8_-_42065075 2.388 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
 PLAT



plasminogen activator, tissue



chr8_-_42065187 2.212 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
 PLAT


plasminogen activator, tissue


chr7_+_143079000 1.985 ENST00000392910.2
 ZYX
zyxin
chr19_+_10397621 1.934 ENST00000380770.3
 ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 1.916 ENST00000340992.4
ENST00000393717.2
 ICAM4

intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

chr8_+_22022800 1.819 ENST00000397814.3
 BMP1
bone morphogenetic protein 1
chr12_-_54813229 1.759 ENST00000293379.4
 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_+_7344057 1.722 ENST00000575398.1
ENST00000575082.1
 FGF11

fibroblast growth factor 11

chr7_+_143078652 1.709 ENST00000354434.4
ENST00000449423.2
 ZYX

zyxin

chr20_+_58251716 1.705 ENST00000355648.4
 PHACTR3
phosphatase and actin regulator 3
chr7_+_116165038 1.660 ENST00000393470.1
 CAV1
caveolin 1, caveolae protein, 22kDa
chr14_+_85996471 1.634 ENST00000330753.4
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr20_+_33759854 1.518 ENST00000216968.4
 PROCR
protein C receptor, endothelial
chr12_+_13349650 1.492 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
 EMP1



epithelial membrane protein 1



chr14_+_24867992 1.406 ENST00000382554.3
 NYNRIN
NYN domain and retroviral integrase containing
chr2_-_192711968 1.390 ENST00000304141.4
 SDPR
serum deprivation response
chr3_+_186915274 1.339 ENST00000312295.4
 RTP1
receptor (chemosensory) transporter protein 1
chrX_-_128788914 1.335 ENST00000429967.1
ENST00000307484.6
 APLN

apelin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 154 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.6 GO:0031639 plasminogen activation(GO:0031639)
0.0 3.8 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
1.0 2.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 2.9 GO:0001502 cartilage condensation(GO:0001502)
0.4 2.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 2.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 2.3 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.7 2.0 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.2 1.9 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.2 1.9 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 1.8 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.6 1.7 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.4 1.6 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 1.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 1.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 1.5 GO:0032060 bleb assembly(GO:0032060)
0.2 1.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.4 GO:0015074 DNA integration(GO:0015074)
0.0 1.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 1.4 GO:0030574 collagen catabolic process(GO:0030574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.8 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 3.7 GO:0005610 laminin-5 complex(GO:0005610)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 2.0 GO:0097228 sperm principal piece(GO:0097228)
0.4 1.8 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 1.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.6 GO:0042588 zymogen granule(GO:0042588)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 1.4 GO:0043202 lysosomal lumen(GO:0043202)
0.3 1.3 GO:0036156 inner dynein arm(GO:0036156)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.1 GO:0035976 AP1 complex(GO:0035976)
0.1 1.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3 0.9 GO:0072563 endothelial microparticle(GO:0072563)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0005178 integrin binding(GO:0005178)
0.0 4.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 2.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 2.6 GO:0045499 chemorepellent activity(GO:0045499)
0.2 2.1 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.7 2.0 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)
0.6 1.7 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 1.4 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3 1.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 1.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.4 1.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.2 1.2 GO:0035662 Toll-like receptor 4 binding(GO:0035662)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.2 3.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 2.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.5 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.1 2.1 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 2.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.3 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.6 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.5 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 7.1 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.1 2.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 2.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.7 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 2.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.3 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.2 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.2 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.1 1.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.8 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.8 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 0.6 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions