Motif ID: TLX1_NFIC
Z-value: 1.191
Transcription factors associated with TLX1_NFIC:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
NFIC | ENSG00000141905.13 | NFIC |
TLX1 | ENSG00000107807.8 | TLX1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
TLX1 | hg19_v2_chr10_+_102891048_102891078 | 0.33 | 1.1e-01 | Click! |
NFIC | hg19_v2_chr19_+_3359561_3359681 | -0.05 | 8.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 2.9 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
0.7 | 2.0 | GO:0033242 | regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283) |
0.6 | 1.7 | GO:1900085 | negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609) |
0.4 | 1.3 | GO:0043397 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) regulation of G-protein coupled receptor internalization(GO:1904020) |
0.4 | 2.6 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
0.4 | 1.6 | GO:1902460 | regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462) |
0.3 | 1.5 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
0.3 | 0.9 | GO:0001300 | chronological cell aging(GO:0001300) |
0.3 | 0.8 | GO:0050902 | leukocyte adhesive activation(GO:0050902) |
0.2 | 1.9 | GO:1900127 | positive regulation of hyaluronan biosynthetic process(GO:1900127) |
0.2 | 1.9 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
0.2 | 1.1 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
0.2 | 1.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
0.2 | 0.7 | GO:0090294 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
0.2 | 0.6 | GO:0002384 | hepatic immune response(GO:0002384) |
0.2 | 2.3 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
0.2 | 0.6 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
0.2 | 1.2 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
0.2 | 4.6 | GO:0031639 | plasminogen activation(GO:0031639) |
0.2 | 0.6 | GO:0061107 | seminal vesicle development(GO:0061107) |
0.2 | 1.4 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
0.1 | 0.6 | GO:0015783 | GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079) |
0.1 | 1.1 | GO:0001661 | conditioned taste aversion(GO:0001661) |
0.1 | 1.5 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.1 | 0.3 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
0.1 | 0.4 | GO:0003099 | positive regulation of the force of heart contraction by chemical signal(GO:0003099) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
0.1 | 1.1 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
0.1 | 0.5 | GO:1900106 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
0.1 | 1.2 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
0.1 | 1.8 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
0.1 | 2.9 | GO:0001502 | cartilage condensation(GO:0001502) |
0.1 | 1.4 | GO:0015074 | DNA integration(GO:0015074) |
0.1 | 0.4 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
0.1 | 0.8 | GO:0030578 | PML body organization(GO:0030578) |
0.1 | 1.3 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
0.1 | 0.5 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
0.1 | 0.4 | GO:0072092 | ureteric bud invasion(GO:0072092) |
0.1 | 2.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.1 | 0.4 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
0.1 | 0.5 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
0.1 | 0.3 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
0.1 | 0.2 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
0.1 | 0.2 | GO:0044376 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
0.1 | 0.5 | GO:0070966 | nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) |
0.1 | 0.2 | GO:1903207 | neuron death in response to hydrogen peroxide(GO:0036476) regulation of hydrogen peroxide-induced neuron death(GO:1903207) negative regulation of hydrogen peroxide-induced neuron death(GO:1903208) |
0.1 | 0.4 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
0.1 | 0.4 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
0.1 | 0.5 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
0.1 | 0.4 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
0.1 | 0.2 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
0.1 | 0.2 | GO:0002277 | myeloid dendritic cell activation involved in immune response(GO:0002277) |
0.1 | 0.2 | GO:0097359 | UDP-glucosylation(GO:0097359) |
0.1 | 0.8 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
0.1 | 0.3 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
0.1 | 1.2 | GO:0034063 | stress granule assembly(GO:0034063) |
0.1 | 0.3 | GO:1902044 | regulation of Fas signaling pathway(GO:1902044) |
0.1 | 0.3 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
0.1 | 0.5 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
0.1 | 1.1 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
0.1 | 0.4 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
0.1 | 0.4 | GO:0060737 | prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) |
0.1 | 0.5 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
0.1 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
0.1 | 0.7 | GO:0006089 | lactate metabolic process(GO:0006089) |
0.1 | 1.5 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 0.3 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
0.1 | 0.6 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 0.3 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
0.1 | 0.8 | GO:0051639 | actin filament network formation(GO:0051639) |
0.1 | 0.4 | GO:1904970 | brush border assembly(GO:1904970) |
0.0 | 0.2 | GO:1901355 | response to rapamycin(GO:1901355) |
0.0 | 1.1 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
0.0 | 0.7 | GO:0051451 | myoblast migration(GO:0051451) |
0.0 | 0.3 | GO:0048241 | epinephrine transport(GO:0048241) |
0.0 | 0.1 | GO:0043686 | co-translational protein modification(GO:0043686) |
0.0 | 1.0 | GO:0045109 | intermediate filament organization(GO:0045109) |
0.0 | 0.3 | GO:0090131 | mesenchyme migration(GO:0090131) |
0.0 | 0.3 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
0.0 | 0.6 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
0.0 | 0.6 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
0.0 | 0.1 | GO:1902731 | negative regulation of chondrocyte proliferation(GO:1902731) |
0.0 | 0.1 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
0.0 | 1.4 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
0.0 | 0.2 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
0.0 | 0.4 | GO:0018230 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
0.0 | 0.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
0.0 | 0.4 | GO:0009407 | toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487) |
0.0 | 0.1 | GO:1903674 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
0.0 | 0.1 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
0.0 | 0.5 | GO:0038065 | collagen-activated signaling pathway(GO:0038065) |
0.0 | 0.1 | GO:0061537 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
0.0 | 0.1 | GO:0018874 | benzoate metabolic process(GO:0018874) |
0.0 | 0.2 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.0 | 0.6 | GO:0033622 | integrin activation(GO:0033622) |
0.0 | 0.2 | GO:2000568 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
0.0 | 0.1 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
0.0 | 0.1 | GO:0003335 | corneocyte development(GO:0003335) |
0.0 | 0.1 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
0.0 | 0.1 | GO:0022614 | membrane to membrane docking(GO:0022614) |
0.0 | 0.6 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
0.0 | 0.2 | GO:0090116 | C-5 methylation of cytosine(GO:0090116) |
0.0 | 0.9 | GO:0048268 | clathrin coat assembly(GO:0048268) |
0.0 | 1.3 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
0.0 | 0.4 | GO:2001224 | positive regulation of neuron migration(GO:2001224) |
0.0 | 0.2 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
0.0 | 0.4 | GO:0048368 | lateral mesoderm development(GO:0048368) |
0.0 | 0.4 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
0.0 | 3.8 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.4 | GO:0070234 | positive regulation of T cell apoptotic process(GO:0070234) |
0.0 | 0.3 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
0.0 | 0.4 | GO:0002544 | chronic inflammatory response(GO:0002544) |
0.0 | 0.7 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
0.0 | 0.2 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
0.0 | 0.2 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
0.0 | 0.2 | GO:0051964 | negative regulation of synapse assembly(GO:0051964) |
0.0 | 0.1 | GO:0045719 | inorganic diphosphate transport(GO:0030505) negative regulation of glycogen biosynthetic process(GO:0045719) |
0.0 | 1.2 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
0.0 | 0.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.0 | 0.8 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
0.0 | 0.1 | GO:0018894 | dibenzo-p-dioxin metabolic process(GO:0018894) |
0.0 | 0.3 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.0 | 0.1 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
0.0 | 0.9 | GO:0050919 | negative chemotaxis(GO:0050919) |
0.0 | 0.6 | GO:0005980 | glycogen catabolic process(GO:0005980) |
0.0 | 0.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
0.0 | 1.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.0 | 0.1 | GO:0038165 | oncostatin-M-mediated signaling pathway(GO:0038165) |
0.0 | 0.7 | GO:0045687 | positive regulation of glial cell differentiation(GO:0045687) |
0.0 | 0.3 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
0.0 | 0.1 | GO:1904647 | response to rotenone(GO:1904647) |
0.0 | 0.1 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.0 | 0.2 | GO:0097264 | self proteolysis(GO:0097264) |
0.0 | 0.4 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
0.0 | 0.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.0 | 0.1 | GO:0051182 | coenzyme transport(GO:0051182) |
0.0 | 1.0 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 0.2 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
0.0 | 0.2 | GO:0034214 | protein hexamerization(GO:0034214) |
0.0 | 0.5 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
0.0 | 0.2 | GO:0045792 | negative regulation of cell size(GO:0045792) |
0.0 | 0.2 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
0.0 | 0.1 | GO:1901525 | negative regulation of macromitophagy(GO:1901525) |
0.0 | 0.4 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
0.0 | 0.2 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
0.0 | 0.2 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
0.0 | 0.1 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
0.0 | 0.2 | GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241) |
0.0 | 0.6 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
0.0 | 0.5 | GO:0030818 | negative regulation of cAMP biosynthetic process(GO:0030818) |
0.0 | 0.3 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
0.0 | 0.3 | GO:0007520 | myoblast fusion(GO:0007520) |
0.0 | 0.0 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
0.0 | 0.0 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 3.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
0.4 | 1.8 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
0.3 | 1.3 | GO:0036156 | inner dynein arm(GO:0036156) |
0.3 | 0.9 | GO:0072563 | endothelial microparticle(GO:0072563) |
0.2 | 0.6 | GO:0036025 | protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183) |
0.2 | 0.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
0.2 | 0.5 | GO:0034681 | integrin alpha11-beta1 complex(GO:0034681) |
0.1 | 1.1 | GO:0035976 | AP1 complex(GO:0035976) |
0.1 | 1.7 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
0.1 | 0.5 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
0.1 | 0.1 | GO:0034665 | integrin alpha1-beta1 complex(GO:0034665) |
0.1 | 1.1 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
0.1 | 1.2 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.1 | 0.6 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
0.1 | 1.6 | GO:0042588 | zymogen granule(GO:0042588) |
0.1 | 0.6 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
0.1 | 2.0 | GO:0097228 | sperm principal piece(GO:0097228) |
0.0 | 0.1 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
0.0 | 0.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
0.0 | 0.4 | GO:0031931 | TORC1 complex(GO:0031931) |
0.0 | 0.3 | GO:0097452 | GAIT complex(GO:0097452) |
0.0 | 0.8 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.0 | 0.2 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
0.0 | 4.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
0.0 | 0.4 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
0.0 | 0.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
0.0 | 0.1 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
0.0 | 0.7 | GO:0042627 | chylomicron(GO:0042627) |
0.0 | 0.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
0.0 | 0.4 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
0.0 | 0.3 | GO:0097433 | dense body(GO:0097433) |
0.0 | 0.3 | GO:0005642 | annulate lamellae(GO:0005642) |
0.0 | 0.2 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 0.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.0 | 0.1 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
0.0 | 0.8 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
0.0 | 0.7 | GO:0043034 | costamere(GO:0043034) |
0.0 | 2.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 1.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
0.0 | 0.4 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 0.4 | GO:0010369 | chromocenter(GO:0010369) |
0.0 | 9.8 | GO:0031012 | extracellular matrix(GO:0031012) |
0.0 | 0.7 | GO:0000791 | euchromatin(GO:0000791) |
0.0 | 1.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
0.0 | 1.1 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
0.0 | 0.3 | GO:0032982 | myosin filament(GO:0032982) |
0.0 | 0.6 | GO:0043025 | neuronal cell body(GO:0043025) |
0.0 | 1.3 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 1.5 | GO:0016605 | PML body(GO:0016605) |
0.0 | 0.2 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.9 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.2 | GO:0032420 | stereocilium(GO:0032420) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0036487 | nitric-oxide synthase inhibitor activity(GO:0036487) |
0.6 | 1.7 | GO:0070320 | inward rectifier potassium channel inhibitor activity(GO:0070320) |
0.5 | 2.9 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
0.4 | 1.2 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
0.4 | 1.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
0.3 | 1.3 | GO:0031849 | olfactory receptor binding(GO:0031849) |
0.2 | 0.7 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
0.2 | 0.9 | GO:0035501 | MH1 domain binding(GO:0035501) |
0.2 | 1.1 | GO:0050436 | microfibril binding(GO:0050436) |
0.2 | 0.7 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
0.2 | 0.6 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
0.2 | 2.1 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
0.2 | 0.7 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
0.2 | 1.2 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
0.2 | 0.7 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.2 | 2.6 | GO:0045499 | chemorepellent activity(GO:0045499) |
0.2 | 0.5 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
0.1 | 0.6 | GO:0005457 | GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080) |
0.1 | 0.5 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
0.1 | 0.9 | GO:0005534 | galactose binding(GO:0005534) |
0.1 | 0.3 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
0.1 | 0.4 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
0.1 | 0.7 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
0.1 | 0.6 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
0.1 | 0.4 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954) |
0.1 | 0.3 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
0.1 | 0.4 | GO:0004144 | diacylglycerol O-acyltransferase activity(GO:0004144) |
0.1 | 0.2 | GO:0051139 | metal ion:proton antiporter activity(GO:0051139) |
0.1 | 0.2 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
0.1 | 0.3 | GO:0008513 | acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375) |
0.1 | 0.4 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
0.1 | 0.4 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) |
0.1 | 0.3 | GO:0005275 | amine transmembrane transporter activity(GO:0005275) |
0.1 | 0.6 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
0.1 | 0.2 | GO:0003980 | UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) |
0.1 | 0.8 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
0.1 | 0.3 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
0.1 | 0.4 | GO:0050610 | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
0.1 | 0.6 | GO:0032190 | acrosin binding(GO:0032190) |
0.1 | 1.1 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
0.1 | 1.3 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.1 | 0.7 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
0.1 | 0.5 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
0.1 | 1.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
0.1 | 0.4 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
0.1 | 0.4 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
0.1 | 1.4 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.0 | 1.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.0 | 0.1 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
0.0 | 0.4 | GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
0.0 | 0.9 | GO:0038191 | neuropilin binding(GO:0038191) |
0.0 | 1.0 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 1.2 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.0 | 0.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.0 | 0.2 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
0.0 | 0.6 | GO:0003796 | lysozyme activity(GO:0003796) |
0.0 | 0.2 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.0 | 1.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.0 | 1.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 0.9 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
0.0 | 4.7 | GO:0051219 | phosphoprotein binding(GO:0051219) |
0.0 | 5.7 | GO:0005178 | integrin binding(GO:0005178) |
0.0 | 0.2 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
0.0 | 4.7 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.0 | 0.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.0 | 0.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
0.0 | 1.4 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
0.0 | 0.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.0 | 0.1 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
0.0 | 0.2 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
0.0 | 0.2 | GO:1990254 | keratin filament binding(GO:1990254) |
0.0 | 0.1 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
0.0 | 0.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.0 | 0.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
0.0 | 1.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
0.0 | 0.1 | GO:0015375 | glycine:sodium symporter activity(GO:0015375) |
0.0 | 1.5 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
0.0 | 1.0 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.0 | 0.6 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.0 | 0.1 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
0.0 | 1.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.1 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.0 | 0.1 | GO:0023030 | MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030) |
0.0 | 1.3 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.2 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
0.0 | 0.3 | GO:0030957 | Tat protein binding(GO:0030957) |
0.0 | 0.4 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
0.0 | 0.1 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
0.0 | 0.2 | GO:0003680 | AT DNA binding(GO:0003680) |
0.0 | 0.1 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
0.0 | 0.4 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
0.0 | 0.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
0.0 | 0.0 | GO:0008426 | protein kinase C inhibitor activity(GO:0008426) |
0.0 | 0.4 | GO:0031489 | myosin V binding(GO:0031489) |
0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.0 | 0.2 | GO:0030414 | peptidase inhibitor activity(GO:0030414) peptidase regulator activity(GO:0061134) |
0.0 | 1.0 | GO:0001618 | virus receptor activity(GO:0001618) |
0.0 | 2.0 | GO:0008083 | growth factor activity(GO:0008083) |
0.0 | 0.2 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
0.0 | 1.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
0.0 | 0.2 | GO:0019864 | IgG binding(GO:0019864) |
0.0 | 0.4 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 0.3 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
0.0 | 0.2 | GO:0043022 | ribosome binding(GO:0043022) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 3.7 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.2 | 8.6 | PID_INTEGRIN2_PATHWAY | Beta2 integrin cell surface interactions |
0.1 | 3.8 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.1 | 3.6 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
0.1 | 2.1 | PID_INTEGRIN_CS_PATHWAY | Integrin family cell surface interactions |
0.1 | 2.7 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
0.1 | 0.6 | ST_STAT3_PATHWAY | STAT3 Pathway |
0.0 | 2.5 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
0.0 | 2.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
0.0 | 2.1 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.0 | 1.3 | PID_AMB2_NEUTROPHILS_PATHWAY | amb2 Integrin signaling |
0.0 | 1.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.0 | 0.5 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 2.8 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.0 | 0.3 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.0 | 0.2 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
0.0 | 0.6 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 0.6 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
0.0 | 0.7 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.0 | 3.9 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.8 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.1 | 0.4 | REACTOME_GAB1_SIGNALOSOME | Genes involved in GAB1 signalosome |
0.1 | 2.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
0.1 | 2.2 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
0.1 | 1.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.1 | 1.9 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
0.1 | 1.1 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.1 | 0.6 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
0.1 | 1.2 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
0.1 | 7.6 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.1 | 1.2 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
0.0 | 1.3 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 7.1 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
0.0 | 0.7 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
0.0 | 0.6 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.8 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 0.2 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
0.0 | 0.7 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
0.0 | 0.2 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
0.0 | 0.5 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
0.0 | 2.7 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
0.0 | 0.3 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.0 | 0.8 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.0 | 0.2 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.0 | 0.2 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
0.0 | 0.3 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 0.6 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.0 | 1.1 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
0.0 | 0.5 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.0 | 0.8 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
0.0 | 0.5 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
0.0 | 0.3 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
0.0 | 0.3 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
0.0 | 0.2 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
0.0 | 0.5 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |