Motif ID: TLX2

Z-value: 0.786


Transcription factors associated with TLX2:

Gene SymbolEntrez IDGene Name
TLX2 ENSG00000115297.9 TLX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX2hg19_v2_chr2_+_74741569_747416200.125.8e-01Click!


Activity profile for motif TLX2.

activity profile for motif TLX2


Sorted Z-values histogram for motif TLX2

Sorted Z-values for motif TLX2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_102928009 3.753 ENST00000404917.2
ENST00000447231.1
 IL1RL1

interleukin 1 receptor-like 1

chr8_+_86376081 2.897 ENST00000285379.5
 CA2
carbonic anhydrase II
chr14_+_54863739 2.351 ENST00000541304.1
 CDKN3
cyclin-dependent kinase inhibitor 3
chr2_+_10262857 2.156 ENST00000304567.5
 RRM2
ribonucleotide reductase M2
chr14_+_54863667 2.151 ENST00000335183.6
 CDKN3
cyclin-dependent kinase inhibitor 3
chr14_+_54863682 2.142 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
 CDKN3



cyclin-dependent kinase inhibitor 3



chr1_-_17304771 1.958 ENST00000375534.3
 MFAP2
microfibrillar-associated protein 2
chr4_+_17812525 1.931 ENST00000251496.2
 NCAPG
non-SMC condensin I complex, subunit G
chr11_+_69924639 1.702 ENST00000538023.1
ENST00000398543.2
 ANO1

anoctamin 1, calcium activated chloride channel

chr1_+_152881014 1.643 ENST00000368764.3
ENST00000392667.2
 IVL

involucrin

chr11_-_123065989 1.570 ENST00000448775.2
 CLMP
CXADR-like membrane protein
chr1_+_152486950 1.543 ENST00000368790.3
 CRCT1
cysteine-rich C-terminal 1
chr10_+_88718397 1.518 ENST00000372017.3
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr1_-_24469602 1.501 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr22_+_31477296 1.497 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
 SMTN




smoothelin




chr10_+_88718314 1.417 ENST00000348795.4
 SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr6_+_24775641 1.393 ENST00000378054.2
ENST00000476555.1
 GMNN

geminin, DNA replication inhibitor

chr10_-_90712520 1.294 ENST00000224784.6
 ACTA2
actin, alpha 2, smooth muscle, aorta
chr3_+_121796697 1.279 ENST00000482356.1
ENST00000393627.2
 CD86

CD86 molecule

chr2_-_190044480 1.230 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.6 3.8 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 3.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.4 3.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
1.0 2.9 GO:0042938 dipeptide transport(GO:0042938)
0.1 2.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.8 2.4 GO:0002644 negative regulation of tolerance induction(GO:0002644) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 2.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.3 2.1 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.0 2.1 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.2 2.0 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.2 1.9 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 1.7 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 1.7 GO:0046847 filopodium assembly(GO:0046847)
0.5 1.6 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.4 1.6 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.1 1.6 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.3 1.5 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 1.5 GO:0015705 iodide transport(GO:0015705)
0.1 1.5 GO:0090178 regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 3.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 2.7 GO:0000796 condensin complex(GO:0000796)
0.0 2.3 GO:0001650 fibrillar center(GO:0001650)
0.4 2.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 2.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 1.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.8 GO:0005768 endosome(GO:0005768)
0.0 1.7 GO:0005902 microvillus(GO:0005902)
0.5 1.6 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.1 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.6 GO:0030057 desmosome(GO:0030057)
0.0 1.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.5 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 1.5 GO:0031143 pseudopodium(GO:0031143)
0.0 1.4 GO:0045095 keratin filament(GO:0045095)
0.0 1.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
1.3 3.8 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 3.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.4 2.9 GO:0004064 arylesterase activity(GO:0004064)
0.0 2.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.7 GO:0048185 activin binding(GO:0048185)
0.4 2.2 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 2.0 GO:0015026 coreceptor activity(GO:0015026)
0.0 2.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.4 1.9 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.3 1.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 1.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.5 1.6 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 1.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 1.5 GO:0008199 ferric iron binding(GO:0008199)
0.1 1.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 1.5 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.4 GO:0017166 vinculin binding(GO:0017166)
0.0 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.7 NABA_CORE_MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 2.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.3 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 1.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.6 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.9 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 3.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.8 REACTOME_IL_2_SIGNALING Genes involved in Interleukin-2 signaling
0.0 2.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 2.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 2.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.7 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.4 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 1.4 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.2 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.0 REACTOME_GAB1_SIGNALOSOME Genes involved in GAB1 signalosome
0.0 0.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.8 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.7 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.7 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins