Motif ID: TP53

Z-value: 0.907


Transcription factors associated with TP53:

Gene SymbolEntrez IDGene Name
TP53 ENSG00000141510.11 TP53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP53hg19_v2_chr17_-_7590745_7590856-0.252.4e-01Click!


Activity profile for motif TP53.

activity profile for motif TP53


Sorted Z-values histogram for motif TP53

Sorted Z-values for motif TP53



Network of associatons between targets according to the STRING database.



First level regulatory network of TP53

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51504411 6.613 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr10_+_11784360 5.226 ENST00000379215.4
ENST00000420401.1
 ECHDC3

enoyl CoA hydratase domain containing 3

chr8_-_10588010 3.423 ENST00000304501.1
 SOX7
SRY (sex determining region Y)-box 7
chr2_+_95691445 3.078 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
 MAL


mal, T-cell differentiation protein


chr2_+_95691417 3.069 ENST00000309988.4
 MAL
mal, T-cell differentiation protein
chr7_+_100770328 2.727 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr20_+_33759854 2.635 ENST00000216968.4
 PROCR
protein C receptor, endothelial
chr17_+_74372662 2.294 ENST00000591651.1
ENST00000545180.1
 SPHK1

sphingosine kinase 1

chr17_+_76210267 2.292 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
 BIRC5



baculoviral IAP repeat containing 5



chr11_+_706595 2.104 ENST00000531348.1
ENST00000530636.1
 EPS8L2

EPS8-like 2

chr17_+_76210367 1.989 ENST00000592734.1
ENST00000587746.1
 BIRC5

baculoviral IAP repeat containing 5

chr9_+_139847347 1.896 ENST00000371632.3
 LCN12
lipocalin 12
chr11_-_2160611 1.870 ENST00000416167.2
 IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_+_22778291 1.802 ENST00000545979.1
 ETNK1
ethanolamine kinase 1
chrX_+_99899180 1.611 ENST00000373004.3
 SRPX2
sushi-repeat containing protein, X-linked 2
chr10_-_105212059 1.574 ENST00000260743.5
 CALHM2
calcium homeostasis modulator 2
chr6_-_30712313 1.573 ENST00000376377.2
ENST00000259874.5
 IER3

immediate early response 3

chr8_-_23021533 1.363 ENST00000312584.3
 TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr10_-_105212141 1.356 ENST00000369788.3
 CALHM2
calcium homeostasis modulator 2
chr18_-_28622774 1.348 ENST00000434452.1
 DSC3
desmocollin 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.6 GO:0031642 negative regulation of myelination(GO:0031642)
0.5 6.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 4.3 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 4.1 GO:0001706 endoderm formation(GO:0001706)
0.2 3.5 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 3.5 GO:0070268 cornification(GO:0070268)
0.9 2.7 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 2.6 GO:0050819 negative regulation of coagulation(GO:0050819)
0.3 2.5 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.8 2.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 2.3 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.5 2.1 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.2 2.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 1.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 1.6 GO:0007613 memory(GO:0007613)
0.4 1.5 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 1.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 1.5 GO:0048477 oogenesis(GO:0048477)
0.2 1.3 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 4.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.5 4.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 2.8 GO:0030057 desmosome(GO:0030057)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 1.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.1 1.3 GO:0005642 annulate lamellae(GO:0005642)
0.2 1.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 1.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 1.1 GO:0005638 lamin filament(GO:0005638)
0.3 1.0 GO:0071001 U4/U6 snRNP(GO:0071001)
0.1 1.0 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 1.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.7 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 0.6 GO:0035686 sperm fibrous sheath(GO:0035686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.9 5.6 GO:0045569 TRAIL binding(GO:0045569)
0.1 4.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 4.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.1 GO:0019838 growth factor binding(GO:0019838)
0.0 2.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 2.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 2.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.9 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 1.7 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.3 GO:0034452 dynactin binding(GO:0034452)
0.1 1.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 1.1 GO:0005504 fatty acid binding(GO:0005504)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.6 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 4.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.6 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.2 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 1.1 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.0 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.8 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.6 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.5 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.4 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.2 REACTOME_KINESINS Genes involved in Kinesins
0.1 1.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.8 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse