Motif ID: TP63

Z-value: 1.273


Transcription factors associated with TP63:

Gene SymbolEntrez IDGene Name
TP63 ENSG00000073282.8 TP63

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP63hg19_v2_chr3_+_189507432_1895074590.834.1e-07Click!


Activity profile for motif TP63.

activity profile for motif TP63


Sorted Z-values histogram for motif TP63

Sorted Z-values for motif TP63



Network of associatons between targets according to the STRING database.



First level regulatory network of TP63

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51504411 10.855 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr19_-_51471381 5.759 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_19051103 3.936 ENST00000542541.2
ENST00000433218.2
 HOMER3

homer homolog 3 (Drosophila)

chr1_+_151030234 3.438 ENST00000368921.3
 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr2_-_216003127 3.348 ENST00000412081.1
ENST00000272895.7
 ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12

chr12_-_52845910 3.335 ENST00000252252.3
 KRT6B
keratin 6B
chr4_-_10023095 3.118 ENST00000264784.3
 SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr20_-_43280325 3.070 ENST00000537820.1
 ADA
adenosine deaminase
chr2_-_31361543 2.862 ENST00000349752.5
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr10_+_102106829 2.734 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr12_+_119616447 2.713 ENST00000281938.2
 HSPB8
heat shock 22kDa protein 8
chrX_-_153602991 2.698 ENST00000369850.3
ENST00000422373.1
 FLNA

filamin A, alpha

chr3_-_50340996 2.620 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
 HYAL1





hyaluronoglucosaminidase 1





chr1_+_17575584 2.569 ENST00000375460.3
 PADI3
peptidyl arginine deiminase, type III
chr1_-_26197744 2.566 ENST00000374296.3
 PAQR7
progestin and adipoQ receptor family member VII
chr1_+_86889769 2.524 ENST00000370565.4
 CLCA2
chloride channel accessory 2
chr20_-_43280361 2.508 ENST00000372874.4
 ADA
adenosine deaminase
chr18_+_34124507 2.493 ENST00000591635.1
 FHOD3
formin homology 2 domain containing 3
chr22_+_31489344 2.233 ENST00000404574.1
 SMTN
smoothelin
chr10_+_99344104 2.169 ENST00000555577.1
ENST00000370649.3
 PI4K2A
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.9 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 5.7 GO:0016540 protein autoprocessing(GO:0016540)
1.9 5.6 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.3 4.6 GO:0051639 actin filament network formation(GO:0051639)
0.2 4.5 GO:0090179 planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 4.4 GO:0016266 O-glycan processing(GO:0016266)
0.2 4.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 3.6 GO:0016579 protein deubiquitination(GO:0016579)
1.1 3.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.7 3.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 3.4 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
0.8 3.3 GO:0035627 ceramide transport(GO:0035627)
0.2 3.1 GO:0046415 urate metabolic process(GO:0046415)
0.1 3.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 3.0 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 2.8 GO:0007398 ectoderm development(GO:0007398)
0.0 2.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.9 2.7 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.4 2.7 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.7 2.6 GO:1900106 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 21.4 GO:0005615 extracellular space(GO:0005615)
0.1 7.2 GO:0045178 basal part of cell(GO:0045178)
0.2 5.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 4.5 GO:0045095 keratin filament(GO:0045095)
0.1 3.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 3.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.5 3.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 2.8 GO:0005865 striated muscle thin filament(GO:0005865)
0.9 2.7 GO:0031523 Myb complex(GO:0031523)
0.0 2.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.5 2.3 GO:0035838 growing cell tip(GO:0035838)
0.1 1.9 GO:0097512 cardiac myofibril(GO:0097512)
0.2 1.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.8 GO:0005916 fascia adherens(GO:0005916)
0.1 1.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.7 GO:0031941 filamentous actin(GO:0031941)
0.0 1.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 5.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 5.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.9 5.5 GO:0045569 TRAIL binding(GO:0045569)
0.2 4.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 3.9 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
1.1 3.4 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.2 3.4 GO:0008199 ferric iron binding(GO:0008199)
0.8 3.3 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.2 3.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 3.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.7 2.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.5 2.7 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.7 2.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.5 2.6 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 2.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 2.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.5 2.2 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.1 2.1 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 5.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 2.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.2 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.7 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.2 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.5 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 4.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 3.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 3.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 3.1 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 3.0 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 2.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 2.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 2.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.9 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 1.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 1.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PE Genes involved in Acyl chain remodelling of PE
0.1 1.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.5 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification