Motif ID: TP73

Z-value: 0.474


Transcription factors associated with TP73:

Gene SymbolEntrez IDGene Name
TP73 ENSG00000078900.10 TP73

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3614591_3614622-0.311.4e-01Click!


Activity profile for motif TP73.

activity profile for motif TP73


Sorted Z-values histogram for motif TP73

Sorted Z-values for motif TP73



Network of associatons between targets according to the STRING database.



First level regulatory network of TP73

PNG image of the network

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Top targets:


Showing 1 to 20 of 139 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_46703069 0.420 ENST00000538237.1
ENST00000274793.7
 PLA2G7

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

chr1_-_236228417 0.384 ENST00000264187.6
 NID1
nidogen 1
chr1_-_236228403 0.377 ENST00000366595.3
 NID1
nidogen 1
chrX_+_130192318 0.376 ENST00000370922.1
 ARHGAP36
Rho GTPase activating protein 36
chr8_+_120885949 0.366 ENST00000523492.1
ENST00000286234.5
 DEPTOR

DEP domain containing MTOR-interacting protein

chr20_-_52790512 0.361 ENST00000216862.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr16_-_20367584 0.343 ENST00000570689.1
 UMOD
uromodulin
chr17_-_42452063 0.319 ENST00000588098.1
 ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chr22_-_37976082 0.305 ENST00000215886.4
 LGALS2
lectin, galactoside-binding, soluble, 2
chr18_-_28681950 0.294 ENST00000251081.6
 DSC2
desmocollin 2
chrX_+_130192216 0.282 ENST00000276211.5
 ARHGAP36
Rho GTPase activating protein 36
chrX_+_72667090 0.282 ENST00000373514.2
 CDX4
caudal type homeobox 4
chr1_-_203055129 0.281 ENST00000241651.4
 MYOG
myogenin (myogenic factor 4)
chr1_+_26485511 0.271 ENST00000374268.3
 FAM110D
family with sequence similarity 110, member D
chr20_-_52790055 0.267 ENST00000395955.3
 CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1
chr1_-_26197744 0.257 ENST00000374296.3
 PAQR7
progestin and adipoQ receptor family member VII
chr6_-_46703430 0.250 ENST00000537365.1
 PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_-_74043816 0.243 ENST00000379822.4
 C15orf59
chromosome 15 open reading frame 59
chr14_+_105190514 0.242 ENST00000330877.2
 ADSSL1
adenylosuccinate synthase like 1
chr1_+_47137445 0.240 ENST00000569393.1
ENST00000334122.4
ENST00000415500.1
 TEX38


testis expressed 38



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0032836 glomerular basement membrane development(GO:0032836)
0.1 0.7 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 0.7 GO:0051601 exocyst localization(GO:0051601)
0.2 0.6 GO:0042369 vitamin D catabolic process(GO:0042369)
0.1 0.4 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.4 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 0.3 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.3 GO:1903862 regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.3 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.2 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.1 0.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 0.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.2 GO:0071400 cellular response to oleic acid(GO:0071400)
0.0 0.2 GO:0021553 olfactory nerve development(GO:0021553)
0.0 0.2 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)

Gene overrepresentation in cellular_component category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.1 0.4 GO:0044393 microspike(GO:0044393)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.1 GO:1990742 microvesicle(GO:1990742)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 0.6 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 0.5 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.3 GO:0070051 fibrinogen binding(GO:0070051)
0.1 0.3 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.1 0.2 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.2 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.1 0.2 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.0 0.2 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen