Motif ID: TWIST1_SNAI1

Z-value: 0.939

Transcription factors associated with TWIST1_SNAI1:

Gene SymbolEntrez IDGene Name
SNAI1 ENSG00000124216.3 SNAI1
TWIST1 ENSG00000122691.8 TWIST1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SNAI1hg19_v2_chr20_+_48599506_485995360.203.6e-01Click!
TWIST1hg19_v2_chr7_-_19157248_191572950.184.1e-01Click!


Activity profile for motif TWIST1_SNAI1.

activity profile for motif TWIST1_SNAI1


Sorted Z-values histogram for motif TWIST1_SNAI1

Sorted Z-values for motif TWIST1_SNAI1



Network of associatons between targets according to the STRING database.



First level regulatory network of TWIST1_SNAI1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_111314230 3.316 ENST00000317012.4
 ZBED2
zinc finger, BED-type containing 2
chr19_-_51471362 3.170 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 3.134 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr9_+_35673853 3.082 ENST00000378357.4
 CA9
carbonic anhydrase IX
chr22_+_31489344 3.042 ENST00000404574.1
 SMTN
smoothelin
chr19_-_51456198 2.887 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr15_+_90728145 2.868 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
 SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr19_+_54926621 2.446 ENST00000376530.3
ENST00000445095.1
ENST00000391739.3
ENST00000376531.3
 TTYH1



tweety family member 1



chr19_+_54926601 2.390 ENST00000301194.4
 TTYH1
tweety family member 1
chr17_-_39553844 2.191 ENST00000251645.2
 KRT31
keratin 31
chr9_-_123638633 2.108 ENST00000456291.1
 PHF19
PHD finger protein 19
chr15_+_81071684 2.072 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
 KIAA1199


KIAA1199


chr4_+_8201091 1.989 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
 SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr18_+_47088401 1.962 ENST00000261292.4
ENST00000427224.2
ENST00000580036.1
 LIPG


lipase, endothelial


chr1_-_113498616 1.786 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
 SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr16_+_88704978 1.734 ENST00000244241.4
 IL17C
interleukin 17C
chr22_+_19467261 1.699 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
 CDC45



cell division cycle 45



chr4_-_10023095 1.513 ENST00000264784.3
 SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr19_+_38810447 1.483 ENST00000263372.3
 KCNK6
potassium channel, subfamily K, member 6
chr4_-_57522598 1.451 ENST00000553379.2
 HOPX
HOP homeobox

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 412 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 GO:0070268 cornification(GO:0070268)
0.3 6.5 GO:0016540 protein autoprocessing(GO:0016540)
0.2 5.8 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.6 4.5 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 4.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 3.3 GO:0050919 negative chemotaxis(GO:0050919)
0.5 2.9 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 2.9 GO:0048711 positive regulation of astrocyte differentiation(GO:0048711)
0.1 2.9 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 2.8 GO:0033227 dsRNA transport(GO:0033227)
0.5 2.6 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.8 2.4 GO:0045062 extrathymic T cell selection(GO:0045062)
0.0 2.3 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.2 2.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.5 2.0 GO:0010982 regulation of high-density lipoprotein particle clearance(GO:0010982)
0.3 2.0 GO:0007296 vitellogenesis(GO:0007296)
0.6 1.8 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.6 1.8 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.2 1.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.2 1.8 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 120 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.6 5.2 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 5.2 GO:0005882 intermediate filament(GO:0005882)
0.4 3.9 GO:0031528 microvillus membrane(GO:0031528)
0.0 3.4 GO:0042641 actomyosin(GO:0042641)
1.0 2.9 GO:0097453 mesaxon(GO:0097453) ensheathing process(GO:1990015)
0.4 2.9 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.9 GO:0030057 desmosome(GO:0030057)
0.4 1.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.2 1.8 GO:0005587 collagen type IV trimer(GO:0005587)
0.6 1.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 1.5 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.5 GO:0005922 connexon complex(GO:0005922)
0.0 1.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 1.3 GO:0043259 laminin-10 complex(GO:0043259)
0.4 1.2 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 246 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 8.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.8 4.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 3.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.2 GO:0038191 neuropilin binding(GO:0038191)
0.2 3.0 GO:0033691 sialic acid binding(GO:0033691)
0.2 2.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.7 GO:0005125 cytokine activity(GO:0005125)
0.0 2.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.3 2.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 2.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.6 1.8 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.3 1.8 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 1.8 GO:0019841 retinol binding(GO:0019841)
0.1 1.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 1.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.7 GO:0005095 GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 6.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 4.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 2.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.1 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 6.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 4.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.9 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.9 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 2.4 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 2.3 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 2.2 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 2.2 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 1.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.9 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 1.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.2 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network