Motif ID: UAGUGUU

Z-value: 0.729





Activity profile for motif UAGUGUU.

activity profile for motif UAGUGUU


Sorted Z-values histogram for motif UAGUGUU

Sorted Z-values for motif UAGUGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of UAGUGUU

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_25102252 2.732 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr5_-_39219705 2.062 ENST00000351578.6
FYB
FYN binding protein
chr20_+_37554955 1.695 ENST00000217429.4
FAM83D
family with sequence similarity 83, member D
chr7_+_36429409 1.361 ENST00000265748.2
ANLN
anillin, actin binding protein
chr2_-_113542063 1.330 ENST00000263339.3
IL1A
interleukin 1, alpha
chr12_-_54813229 1.275 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr22_+_33197683 1.266 ENST00000266085.6
TIMP3
TIMP metallopeptidase inhibitor 3
chr20_-_23030296 1.219 ENST00000377103.2
THBD
thrombomodulin
chr14_-_35182994 1.152 ENST00000341223.3
CFL2
cofilin 2 (muscle)
chr3_+_172468472 1.063 ENST00000232458.5
ENST00000392692.3
ECT2

epithelial cell transforming sequence 2 oncogene

chr1_+_182992545 1.042 ENST00000258341.4
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr3_+_47324424 0.964 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
KLHL18


kelch-like family member 18


chr4_-_80994210 0.920 ENST00000403729.2
ANTXR2
anthrax toxin receptor 2
chr7_-_98741642 0.900 ENST00000361368.2
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
chr9_+_131644388 0.889 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr14_+_55034599 0.870 ENST00000392067.3
ENST00000357634.3
SAMD4A

sterile alpha motif domain containing 4A

chr1_+_40420802 0.846 ENST00000372811.5
ENST00000420632.2
ENST00000434861.1
ENST00000372809.5
MFSD2A



major facilitator superfamily domain containing 2A



chr3_-_98620500 0.825 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr10_+_76871454 0.813 ENST00000372687.4
SAMD8
sterile alpha motif domain containing 8
chr9_-_113800317 0.802 ENST00000374431.3
LPAR1
lysophosphatidic acid receptor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 1.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.7 GO:0072698 protein localization to microtubule cytoskeleton(GO:0072698)
0.1 1.5 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 1.5 GO:0070831 basement membrane assembly(GO:0070831)
0.5 1.4 GO:1904170 regulation of bleb assembly(GO:1904170) positive regulation of bleb assembly(GO:1904172)
0.3 1.3 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.2 1.3 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.1 1.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.1 1.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 1.1 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3 0.9 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 0.9 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.9 GO:1901998 toxin transport(GO:1901998)
0.0 0.9 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.2 0.8 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.1 0.8 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.8 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.7 GO:0007296 vitellogenesis(GO:0007296)
0.1 0.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.3 1.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 1.4 GO:0043198 dendritic shaft(GO:0043198)
0.3 1.3 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 1.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.1 GO:0097149 centralspindlin complex(GO:0097149)
0.3 1.0 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.0 1.0 GO:0032433 filopodium tip(GO:0032433)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.7 GO:0000811 GINS complex(GO:0000811)
0.2 0.7 GO:0045160 myosin I complex(GO:0045160)
0.2 0.7 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 2.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.9 GO:0019894 kinesin binding(GO:0019894)
0.1 1.3 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.8 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 0.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.8 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.8 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.7 GO:0004906 interferon-gamma receptor activity(GO:0004906)
0.0 0.7 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.7 GO:0005080 protein kinase C binding(GO:0005080)
0.2 0.6 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.8 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 1.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.4 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.4 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 1.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.0 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.9 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.8 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 1.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 0.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 0.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters