Motif ID: UCACAUU

Z-value: 0.367


Mature miRNA associated with seed UCACAUU:

NamemiRBase Accession
hsa-miR-130a-5p MIMAT0004593
hsa-miR-23a-3p MIMAT0000078
hsa-miR-23b-3p MIMAT0000418
hsa-miR-23c MIMAT0018000



Activity profile for motif UCACAUU.

activity profile for motif UCACAUU


Sorted Z-values histogram for motif UCACAUU

Sorted Z-values for motif UCACAUU



Network of associatons between targets according to the STRING database.



First level regulatory network of UCACAUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_46598284 0.570 ENST00000423209.1
ENST00000262741.5
 PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr6_-_39197226 0.546 ENST00000359534.3
 KCNK5
potassium channel, subfamily K, member 5
chr4_-_23891693 0.512 ENST00000264867.2
 PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr14_+_79745746 0.399 ENST00000281127.7
 NRXN3
neurexin 3
chr11_+_113930291 0.357 ENST00000335953.4
 ZBTB16
zinc finger and BTB domain containing 16
chr3_+_69812877 0.347 ENST00000457080.1
ENST00000328528.6
 MITF

microphthalmia-associated transcription factor

chr18_+_55711575 0.324 ENST00000356462.6
ENST00000400345.3
ENST00000589054.1
ENST00000256832.7
 NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase



chr1_+_107599267 0.254 ENST00000361318.5
ENST00000370078.1
 PRMT6

protein arginine methyltransferase 6

chrX_+_16804544 0.248 ENST00000380122.5
ENST00000398155.4
 TXLNG

taxilin gamma

chr8_+_76452097 0.242 ENST00000396423.2
 HNF4G
hepatocyte nuclear factor 4, gamma
chr10_+_11206925 0.235 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
 CELF2


CUGBP, Elav-like family member 2


chrX_+_44732757 0.231 ENST00000377967.4
ENST00000536777.1
ENST00000382899.4
ENST00000543216.1
 KDM6A



lysine (K)-specific demethylase 6A



chr16_-_19896220 0.231 ENST00000562469.1
ENST00000300571.2
 GPRC5B

G protein-coupled receptor, family C, group 5, member B

chr2_+_46524537 0.206 ENST00000263734.3
 EPAS1
endothelial PAS domain protein 1
chr5_+_140254884 0.203 ENST00000398631.2
 PCDHA12
protocadherin alpha 12
chr3_-_66551351 0.202 ENST00000273261.3
 LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr5_+_140227048 0.198 ENST00000532602.1
 PCDHA9
protocadherin alpha 9
chr5_+_140248518 0.198 ENST00000398640.2
 PCDHA11
protocadherin alpha 11
chr6_-_46138676 0.198 ENST00000371383.2
ENST00000230565.3
 ENPP5

ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)

chr6_+_138188551 0.197 ENST00000237289.4
ENST00000433680.1
 TNFAIP3

tumor necrosis factor, alpha-induced protein 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 0.5 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.1 0.5 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.5 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 0.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 0.3 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.2 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
0.1 0.2 GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.0 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.2 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.2 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.0 0.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.2 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.2 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.2 GO:1902741 interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.0 0.2 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.2 GO:0001887 selenium compound metabolic process(GO:0001887)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.0 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.0 GO:0031091 platelet alpha granule(GO:0031091) platelet alpha granule membrane(GO:0031092)
0.0 0.0 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.2 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.1 0.2 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.2 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.2 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.1 GO:0051538 iron-responsive element binding(GO:0030350) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.5 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1