Motif ID: UUGGCAA

Z-value: 0.508


Mature miRNA associated with seed UUGGCAA:

NamemiRBase Accession
hsa-miR-182-5p MIMAT0000259



Activity profile for motif UUGGCAA.

activity profile for motif UUGGCAA


Sorted Z-values histogram for motif UUGGCAA

Sorted Z-values for motif UUGGCAA



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGGCAA

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_160473996 1.401 ENST00000498165.1
 PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr7_-_158380465 1.294 ENST00000389413.3
ENST00000409483.1
 PTPRN2

protein tyrosine phosphatase, receptor type, N polypeptide 2

chr13_+_24734844 1.279 ENST00000382108.3
 SPATA13
spermatogenesis associated 13
chr6_+_135502466 1.190 ENST00000367814.4
 MYB
v-myb avian myeloblastosis viral oncogene homolog
chr14_+_75536280 1.092 ENST00000238686.8
 ZC2HC1C
zinc finger, C2HC-type containing 1C
chr6_-_10838710 0.958 ENST00000313243.2
 MAK
male germ cell-associated kinase
chr5_-_16509101 0.948 ENST00000399793.2
 FAM134B
family with sequence similarity 134, member B
chr2_-_220110187 0.944 ENST00000295759.7
ENST00000392089.2
 GLB1L

galactosidase, beta 1-like

chr2_+_85981008 0.932 ENST00000306279.3
 ATOH8
atonal homolog 8 (Drosophila)
chr19_+_32896697 0.893 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr1_+_3607228 0.857 ENST00000378285.1
ENST00000378280.1
ENST00000378288.4
 TP73


tumor protein p73


chr3_+_238273 0.847 ENST00000256509.2
 CHL1
cell adhesion molecule L1-like
chr5_+_50678921 0.845 ENST00000230658.7
 ISL1
ISL LIM homeobox 1
chr3_+_69812877 0.827 ENST00000457080.1
ENST00000328528.6
 MITF

microphthalmia-associated transcription factor

chr15_-_49255632 0.801 ENST00000332408.4
 SHC4
SHC (Src homology 2 domain containing) family, member 4
chr1_+_20512568 0.796 ENST00000375099.3
 UBXN10
UBX domain protein 10
chr17_-_1532106 0.787 ENST00000301335.5
ENST00000382147.4
 SLC43A2

solute carrier family 43 (amino acid system L transporter), member 2

chr12_-_56652111 0.784 ENST00000267116.7
 ANKRD52
ankyrin repeat domain 52
chrX_+_16964794 0.782 ENST00000357277.3
 REPS2
RALBP1 associated Eps domain containing 2
chr10_-_46167722 0.747 ENST00000374366.3
ENST00000344646.5
 ZFAND4

zinc finger, AN1-type domain 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.4 1.2 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 1.2 GO:0046847 filopodium assembly(GO:0046847)
0.1 1.0 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 1.0 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.9 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.9 GO:0060044 negative regulation of JUN kinase activity(GO:0043508) negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.3 0.8 GO:0021524 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913)
0.0 0.8 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.8 GO:0035640 exploration behavior(GO:0035640)
0.0 0.8 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 0.7 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.2 0.6 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.6 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.1 0.6 GO:0071233 cellular response to leucine(GO:0071233)
0.1 0.6 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.6 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.6 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.0 0.6 GO:0035404 histone-serine phosphorylation(GO:0035404) fatty acid homeostasis(GO:0055089)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0097542 ciliary tip(GO:0097542)
0.0 1.3 GO:0043195 terminal bouton(GO:0043195)
0.0 1.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.6 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 0.5 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.4 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.4 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 0.3 GO:0043235 receptor complex(GO:0043235)
0.1 0.3 GO:0031251 PAN complex(GO:0031251)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.8 GO:0070888 E-box binding(GO:0070888)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 0.9 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 0.9 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.7 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 0.6 GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity(GO:0047322) [acetyl-CoA carboxylase] kinase activity(GO:0050405)
0.2 0.6 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 0.6 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.0 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.4 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.2 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.2 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.6 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.5 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS Genes involved in Prolonged ERK activation events
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex