Motif ID: UUGGUCC

Z-value: 0.553


Mature miRNA associated with seed UUGGUCC:

NamemiRBase Accession
hsa-miR-133a-3p.2 MIMAT0000427
hsa-miR-133b MIMAT0000770



Activity profile for motif UUGGUCC.

activity profile for motif UUGGUCC


Sorted Z-values histogram for motif UUGGUCC

Sorted Z-values for motif UUGGUCC



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGGUCC

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_132272504 3.305 ENST00000367976.3
 CTGF
connective tissue growth factor
chr1_-_22469459 1.402 ENST00000290167.6
 WNT4
wingless-type MMTV integration site family, member 4
chr6_+_19837592 1.355 ENST00000378700.3
 ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr5_+_75699040 1.313 ENST00000274364.6
 IQGAP2
IQ motif containing GTPase activating protein 2
chr16_+_58549378 1.248 ENST00000310682.2
ENST00000394266.4
ENST00000219315.4
 SETD6


SET domain containing 6


chr7_+_121513143 1.199 ENST00000393386.2
 PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chrY_+_15016725 1.176 ENST00000336079.3
 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr8_+_17354587 1.150 ENST00000494857.1
ENST00000522656.1
 SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr12_-_63328817 1.076 ENST00000228705.6
 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr1_+_118148556 0.999 ENST00000369448.3
 FAM46C
family with sequence similarity 46, member C
chr7_+_100728720 0.967 ENST00000306085.6
ENST00000412507.1
 TRIM56

tripartite motif containing 56

chr5_+_76506706 0.959 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
 PDE8B




phosphodiesterase 8B




chr17_+_53342311 0.904 ENST00000226067.5
 HLF
hepatic leukemia factor
chr1_-_217262969 0.851 ENST00000361525.3
 ESRRG
estrogen-related receptor gamma
chr3_-_114790179 0.793 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr7_+_91570165 0.792 ENST00000356239.3
ENST00000359028.2
ENST00000358100.2
 AKAP9


A kinase (PRKA) anchor protein 9


chr9_-_20622478 0.777 ENST00000355930.6
ENST00000380338.4
 MLLT3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr8_+_81397876 0.762 ENST00000430430.1
 ZBTB10
zinc finger and BTB domain containing 10
chr16_+_69599861 0.753 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_+_61547894 0.739 ENST00000403491.3
 NFIA
nuclear factor I/A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.3 GO:0034059 response to anoxia(GO:0034059)
0.5 1.4 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034)
0.3 1.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741) seminal vesicle development(GO:0061107)
0.2 1.4 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 1.4 GO:0032608 interferon-beta production(GO:0032608)
0.1 1.3 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 1.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 1.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.4 1.1 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.0 1.0 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 0.8 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.8 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.8 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.2 0.7 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.7 GO:0009450 acetate metabolic process(GO:0006083) glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.1 0.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.7 GO:0072189 ureter development(GO:0072189)
0.0 0.7 GO:0090102 cochlea development(GO:0090102)
0.2 0.6 GO:1990535 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 GO:0005801 cis-Golgi network(GO:0005801)
0.4 1.2 GO:0072534 perineuronal net(GO:0072534)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.7 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.6 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.2 0.5 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 0.5 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 1.4 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 1.1 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.1 0.9 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.9 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.0 0.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 0.7 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.7 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.7 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.6 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.3 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways