Motif ID: VDR
Z-value: 0.794
Transcription factors associated with VDR:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| VDR | ENSG00000111424.6 | VDR |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VDR | hg19_v2_chr12_-_48298785_48298828 | 0.54 | 6.1e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.5 | 2.8 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.4 | 2.5 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.4 | 1.2 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.4 | 1.5 | GO:0042361 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.3 | 1.7 | GO:1902378 | vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040) |
| 0.3 | 1.0 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.3 | 1.3 | GO:0018101 | protein citrullination(GO:0018101) histone citrullination(GO:0036414) |
| 0.2 | 0.7 | GO:1904956 | regulation of endodermal cell fate specification(GO:0042663) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) |
| 0.2 | 0.7 | GO:0045062 | extrathymic T cell selection(GO:0045062) |
| 0.2 | 0.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.2 | 1.0 | GO:0019556 | histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606) |
| 0.2 | 1.0 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction(GO:0010751) |
| 0.2 | 0.5 | GO:0014876 | response to injury involved in regulation of muscle adaptation(GO:0014876) |
| 0.1 | 0.4 | GO:0060545 | CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) positive regulation of necroptotic process(GO:0060545) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452) |
| 0.1 | 0.7 | GO:0021938 | ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) |
| 0.1 | 0.4 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.1 | 0.6 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 0.1 | 0.7 | GO:1903575 | cornified envelope assembly(GO:1903575) |
| 0.1 | 0.3 | GO:0042138 | meiotic DNA double-strand break processing(GO:0000706) meiotic DNA double-strand break formation(GO:0042138) double-strand break repair involved in meiotic recombination(GO:1990918) |
| 0.1 | 0.9 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.1 | 1.1 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 2.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 1.2 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.1 | 0.3 | GO:1990258 | box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258) |
| 0.1 | 0.5 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 0.1 | 0.5 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.1 | 0.5 | GO:0042373 | vitamin K metabolic process(GO:0042373) |
| 0.1 | 0.5 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.1 | 0.3 | GO:0044208 | 'de novo' AMP biosynthetic process(GO:0044208) |
| 0.1 | 6.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 0.3 | GO:1990523 | response to vitamin K(GO:0032571) bone regeneration(GO:1990523) |
| 0.1 | 0.8 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 1.2 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 0.2 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.1 | 1.2 | GO:0043651 | alpha-linolenic acid metabolic process(GO:0036109) linoleic acid metabolic process(GO:0043651) |
| 0.1 | 0.3 | GO:0070086 | ubiquitin-dependent endocytosis(GO:0070086) |
| 0.1 | 0.1 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.1 | 0.3 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.1 | 0.3 | GO:0019249 | lactate biosynthetic process(GO:0019249) |
| 0.1 | 0.9 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.0 | 0.4 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.0 | 0.1 | GO:1904717 | excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719) |
| 0.0 | 0.2 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 0.0 | 2.0 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.0 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.0 | 0.1 | GO:0043311 | positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568) |
| 0.0 | 0.4 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.0 | 0.2 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.0 | 1.0 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity(GO:0032515) |
| 0.0 | 0.2 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.0 | 0.2 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.0 | 0.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.0 | 0.7 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 0.1 | GO:0032058 | positive regulation of translational initiation in response to stress(GO:0032058) |
| 0.0 | 1.8 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 0.4 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.0 | 0.2 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.0 | 1.1 | GO:2000178 | negative regulation of neural precursor cell proliferation(GO:2000178) |
| 0.0 | 0.3 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.0 | 0.2 | GO:0071321 | cellular response to cGMP(GO:0071321) |
| 0.0 | 0.2 | GO:0090166 | Golgi disassembly(GO:0090166) spindle assembly involved in meiosis(GO:0090306) |
| 0.0 | 0.3 | GO:0051026 | chiasma assembly(GO:0051026) |
| 0.0 | 0.5 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.0 | 1.4 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.0 | 0.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 1.1 | GO:0008214 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
| 0.0 | 0.1 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.0 | 0.1 | GO:0042427 | serotonin biosynthetic process(GO:0042427) |
| 0.0 | 0.3 | GO:0051873 | killing by host of symbiont cells(GO:0051873) |
| 0.0 | 0.4 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.0 | 0.6 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.0 | 0.2 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.0 | 0.2 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.0 | 0.3 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.1 | GO:0001983 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) |
| 0.0 | 0.2 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.1 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
| 0.0 | 0.1 | GO:0001300 | chronological cell aging(GO:0001300) |
| 0.0 | 0.5 | GO:0051923 | sulfation(GO:0051923) |
| 0.0 | 0.4 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 0.0 | 0.1 | GO:0035672 | oligopeptide transmembrane transport(GO:0035672) |
| 0.0 | 0.3 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 0.2 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 0.7 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
| 0.0 | 0.1 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.0 | 0.6 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.6 | GO:0035767 | endothelial cell chemotaxis(GO:0035767) |
| 0.0 | 1.5 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 0.1 | GO:0038169 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.0 | 0.2 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 0.0 | 0.1 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.0 | 0.0 | GO:0052199 | negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199) |
| 0.0 | 0.6 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.0 | GO:0043012 | regulation of fusion of sperm to egg plasma membrane(GO:0043012) |
| 0.0 | 0.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.8 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 0.0 | 0.1 | GO:0006933 | immunoglobulin biosynthetic process(GO:0002378) negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.0 | 0.2 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 0.1 | GO:0051660 | establishment of centrosome localization(GO:0051660) |
| 0.0 | 0.2 | GO:0045003 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.0 | 1.2 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.0 | 1.7 | GO:0008543 | fibroblast growth factor receptor signaling pathway(GO:0008543) |
| 0.0 | 0.1 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 0.7 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.0 | 0.0 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.3 | 1.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.3 | 2.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 1.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.1 | 0.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 0.8 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 1.4 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 1.2 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 0.5 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 0.4 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.1 | 0.2 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.1 | 0.5 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 0.5 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.1 | 0.5 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 2.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.2 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.4 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.0 | 0.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 2.0 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.2 | GO:0032798 | Swi5-Sfr1 complex(GO:0032798) |
| 0.0 | 0.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 0.6 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.2 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.0 | 0.6 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.7 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 0.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.4 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 0.1 | GO:0072563 | endothelial microparticle(GO:0072563) |
| 0.0 | 2.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 3.1 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.7 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 1.0 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
| 0.0 | 0.1 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.1 | GO:0070761 | PCAF complex(GO:0000125) pre-snoRNP complex(GO:0070761) |
| 0.0 | 0.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.2 | GO:0001891 | phagocytic cup(GO:0001891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.3 | 1.6 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.3 | 1.3 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.2 | 1.2 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.2 | 0.7 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.2 | 0.7 | GO:0050254 | rhodopsin kinase activity(GO:0050254) |
| 0.2 | 1.2 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
| 0.2 | 1.7 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.2 | 0.9 | GO:0070404 | NADH binding(GO:0070404) |
| 0.2 | 1.0 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.2 | 0.5 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 0.6 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 1.0 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.1 | 2.7 | GO:0019841 | retinol binding(GO:0019841) |
| 0.1 | 0.3 | GO:0004019 | adenylosuccinate synthase activity(GO:0004019) |
| 0.1 | 0.3 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.1 | 0.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 0.5 | GO:0047057 | oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057) |
| 0.1 | 0.6 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 0.1 | 0.3 | GO:1990259 | protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259) |
| 0.1 | 0.5 | GO:0022850 | serotonin-gated cation channel activity(GO:0022850) |
| 0.1 | 0.5 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 1.3 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.1 | 0.3 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.1 | 0.6 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.1 | 0.6 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 0.7 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 0.4 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 0.2 | GO:0008480 | sarcosine dehydrogenase activity(GO:0008480) |
| 0.1 | 0.4 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.0 | 0.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.0 | 1.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.5 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.0 | 0.5 | GO:0035877 | death effector domain binding(GO:0035877) |
| 0.0 | 0.3 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.4 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 1.2 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.6 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.6 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.2 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 0.1 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 0.0 | 0.1 | GO:0031716 | calcitonin receptor binding(GO:0031716) |
| 0.0 | 1.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.1 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.0 | 0.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 1.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.1 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
| 0.0 | 0.1 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 0.4 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.0 | 0.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 5.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.0 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.0 | 0.2 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.0 | 0.7 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.8 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 1.1 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 0.5 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.2 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.0 | 0.5 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.0 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.1 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 0.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 0.2 | GO:0008428 | ribonuclease inhibitor activity(GO:0008428) |
| 0.0 | 0.6 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 1.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.0 | 0.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.1 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.0 | 0.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.2 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 0.1 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.0 | 0.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.1 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.0 | 0.2 | GO:0005165 | neurotrophin receptor binding(GO:0005165) |
| 0.0 | 0.0 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 2.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.1 | GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060) |
| 0.0 | 0.1 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 2.1 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.1 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.3 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 0.7 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.6 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.0 | 0.7 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 0.9 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.7 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.1 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 1.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.0 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 1.2 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 1.0 | REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 2.0 | REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.7 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 1.1 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 2.7 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 1.1 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.0 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.6 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.6 | REACTOME_COMPLEMENT_CASCADE | Genes involved in Complement cascade |
| 0.0 | 1.0 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 1.4 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.5 | REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.0 | 0.8 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.8 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.5 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.3 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.5 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.3 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.5 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 1.5 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.2 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.3 | REACTOME_BETA_DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.5 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.2 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
