Motif ID: VSX1

Z-value: 0.833


Transcription factors associated with VSX1:

Gene SymbolEntrez IDGene Name
VSX1 ENSG00000100987.10 VSX1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
VSX1hg19_v2_chr20_-_25062767_250627790.058.0e-01Click!


Activity profile for motif VSX1.

activity profile for motif VSX1


Sorted Z-values histogram for motif VSX1

Sorted Z-values for motif VSX1



Network of associatons between targets according to the STRING database.



First level regulatory network of VSX1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_35938674 5.304 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
 CAPSL



calcyphosine-like



chr12_+_7014064 3.724 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr12_+_7013897 3.712 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr3_-_197686847 3.373 ENST00000265239.6
 IQCG
IQ motif containing G
chr17_-_1532106 2.746 ENST00000301335.5
ENST00000382147.4
 SLC43A2

solute carrier family 43 (amino acid system L transporter), member 2

chr1_-_36916066 2.486 ENST00000315643.9
 OSCP1
organic solute carrier partner 1
chr12_+_7014126 2.108 ENST00000415834.1
ENST00000436789.1
 LRRC23

leucine rich repeat containing 23

chr1_-_36915880 2.104 ENST00000445843.3
 OSCP1
organic solute carrier partner 1
chr2_-_73460334 1.978 ENST00000258083.2
 PRADC1
protease-associated domain containing 1
chr3_-_148939835 1.781 ENST00000264613.6
 CP
ceruloplasmin (ferroxidase)
chr1_-_36916011 1.704 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
 OSCP1


organic solute carrier partner 1


chr19_+_32897009 1.522 ENST00000342179.5
ENST00000586427.1
 DPY19L3

dpy-19-like 3 (C. elegans)

chr5_-_54468974 1.454 ENST00000381375.2
ENST00000296733.1
ENST00000322374.6
ENST00000334206.5
ENST00000331730.3
 CDC20B




cell division cycle 20B




chr19_+_32896697 1.454 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr11_-_26593779 1.434 ENST00000529533.1
 MUC15
mucin 15, cell surface associated
chrX_-_151999269 1.366 ENST00000370277.3
 CETN2
centrin, EF-hand protein, 2
chr11_-_33913708 1.286 ENST00000257818.2
 LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_138453559 1.274 ENST00000511115.1
 PCDH18
protocadherin 18
chr3_-_112693865 1.249 ENST00000471858.1
ENST00000295863.4
ENST00000308611.3
 CD200R1


CD200 receptor 1


chr11_-_95522907 1.246 ENST00000358780.5
ENST00000542135.1
 FAM76B

family with sequence similarity 76, member B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.1 3.8 GO:0071801 regulation of podosome assembly(GO:0071801)
0.3 3.4 GO:0007288 sperm axoneme assembly(GO:0007288)
0.4 3.0 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 3.0 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.7 GO:0061157 mRNA destabilization(GO:0061157)
0.1 2.7 GO:1902475 neutral amino acid transport(GO:0015804) L-alpha-amino acid transmembrane transport(GO:1902475)
0.3 1.8 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1 1.8 GO:0006825 copper ion transport(GO:0006825)
0.0 1.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.7 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.4 1.6 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
1.5 1.5 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 1.4 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.1 1.3 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 1.2 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.2 1.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.1 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.1 GO:0018149 peptide cross-linking(GO:0018149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 GO:0009925 basal plasma membrane(GO:0009925)
0.1 5.0 GO:0005871 kinesin complex(GO:0005871)
0.0 4.6 GO:0005796 Golgi lumen(GO:0005796)
0.5 3.4 GO:0002177 manchette(GO:0002177)
0.0 3.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.7 GO:0032389 MutLalpha complex(GO:0032389)
0.0 1.6 GO:0016235 aggresome(GO:0016235)
0.1 1.4 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.2 1.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.1 1.2 GO:0034709 methylosome(GO:0034709)
0.2 1.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 1.0 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:0030286 dynein complex(GO:0030286)
0.1 0.9 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.1 0.8 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.2 0.7 GO:0097196 Shu complex(GO:0097196)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 3.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 3.0 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 2.8 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 2.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.3 1.8 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.2 1.8 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.7 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.1 1.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 1.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.3 1.4 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 1.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.2 1.0 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2 1.0 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.3 0.9 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.7 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.2 4.6 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 4.2 REACTOME_KINESINS Genes involved in Kinesins
0.1 2.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 2.5 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.3 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.8 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors