Motif ID: WT1_MTF1_ZBTB7B
Z-value: 1.182



Transcription factors associated with WT1_MTF1_ZBTB7B:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
MTF1 | ENSG00000188786.9 | MTF1 |
WT1 | ENSG00000184937.8 | WT1 |
ZBTB7B | ENSG00000160685.9 | ZBTB7B |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
MTF1 | hg19_v2_chr1_-_38325256_38325292 | -0.51 | 1.1e-02 | Click! |
WT1 | hg19_v2_chr11_-_32457075_32457095 | -0.11 | 6.2e-01 | Click! |
ZBTB7B | hg19_v2_chr1_+_154975258_154975330 | 0.06 | 7.9e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 1,420 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 13.4 | GO:0007386 | compartment pattern specification(GO:0007386) |
1.2 | 12.9 | GO:0034465 | response to carbon monoxide(GO:0034465) |
0.4 | 12.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
0.2 | 12.1 | GO:0061620 | glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) |
0.4 | 9.9 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
0.4 | 9.6 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
0.7 | 9.0 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
0.4 | 8.8 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
0.5 | 8.0 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
0.8 | 7.6 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.7 | 7.1 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
0.7 | 6.8 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
0.5 | 6.4 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
0.2 | 6.1 | GO:0034380 | high-density lipoprotein particle assembly(GO:0034380) |
0.1 | 6.1 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.8 | 6.0 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
1.0 | 5.9 | GO:0002803 | positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803) |
0.5 | 5.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
0.4 | 5.8 | GO:0051639 | actin filament network formation(GO:0051639) |
0.1 | 5.8 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 448 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 31.9 | GO:0005924 | cell-substrate adherens junction(GO:0005924) |
0.2 | 19.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
0.2 | 18.4 | GO:0005901 | caveola(GO:0005901) |
0.1 | 17.9 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
0.0 | 16.9 | GO:0005730 | nucleolus(GO:0005730) |
0.2 | 14.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
0.1 | 12.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.1 | 11.9 | GO:0030027 | lamellipodium(GO:0030027) |
0.4 | 10.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
0.5 | 10.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.1 | 9.2 | GO:0001726 | ruffle(GO:0001726) |
0.2 | 8.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.2 | 8.6 | GO:0005865 | striated muscle thin filament(GO:0005865) |
0.2 | 8.4 | GO:0005921 | gap junction(GO:0005921) |
0.1 | 8.1 | GO:0005604 | basement membrane(GO:0005604) |
0.2 | 7.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.0 | 7.2 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
0.3 | 7.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.1 | 6.9 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
1.4 | 6.8 | GO:0032449 | CBM complex(GO:0032449) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 803 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 39.1 | GO:0045296 | cadherin binding(GO:0045296) |
0.2 | 21.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.1 | 17.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 16.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.2 | 13.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.1 | 13.9 | GO:0005178 | integrin binding(GO:0005178) |
1.5 | 12.1 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
0.3 | 11.5 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.1 | 9.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
2.4 | 9.4 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
0.3 | 9.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.2 | 9.3 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.1 | 9.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.1 | 8.7 | GO:0002020 | protease binding(GO:0002020) |
0.2 | 8.3 | GO:0003785 | actin monomer binding(GO:0003785) |
0.5 | 8.2 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
0.3 | 8.2 | GO:0017166 | vinculin binding(GO:0017166) |
0.4 | 7.6 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.1 | 7.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.0 | 7.0 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 111 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 35.4 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.3 | 15.3 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
0.2 | 14.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.2 | 13.7 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
0.1 | 13.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.3 | 12.3 | PID_RAS_PATHWAY | Regulation of Ras family activation |
0.2 | 11.8 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
0.6 | 11.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.4 | 10.2 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
0.1 | 9.7 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
0.1 | 9.5 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
0.1 | 9.2 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
0.2 | 7.9 | PID_IFNG_PATHWAY | IFN-gamma pathway |
0.1 | 7.8 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.3 | 7.7 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
0.1 | 7.3 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.0 | 7.3 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.1 | 7.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
0.2 | 7.0 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.3 | 6.8 | PID_TCR_RAS_PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 194 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 18.2 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
0.1 | 17.4 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
0.3 | 15.6 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
0.2 | 13.2 | REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
0.2 | 11.9 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.1 | 11.4 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
0.6 | 11.0 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.5 | 11.0 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
0.4 | 10.6 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
0.2 | 9.0 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
0.3 | 8.9 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.3 | 8.9 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.2 | 8.8 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
0.3 | 8.6 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.1 | 8.5 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
0.2 | 8.1 | REACTOME_MUSCLE_CONTRACTION | Genes involved in Muscle contraction |
0.3 | 7.5 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
0.4 | 7.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
0.2 | 7.1 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
0.0 | 6.9 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |