Motif ID: WT1_MTF1_ZBTB7B

Z-value: 1.182

Transcription factors associated with WT1_MTF1_ZBTB7B:

Gene SymbolEntrez IDGene Name
MTF1 ENSG00000188786.9 MTF1
WT1 ENSG00000184937.8 WT1
ZBTB7B ENSG00000160685.9 ZBTB7B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MTF1hg19_v2_chr1_-_38325256_38325292-0.511.1e-02Click!
WT1hg19_v2_chr11_-_32457075_32457095-0.116.2e-01Click!
ZBTB7Bhg19_v2_chr1_+_154975258_1549753300.067.9e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of WT1_MTF1_ZBTB7B

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_128509624 6.843 ENST00000342287.5
ENST00000373487.4
PBX3

pre-B-cell leukemia homeobox 3

chr9_+_128509663 5.965 ENST00000373489.5
ENST00000373483.2
PBX3

pre-B-cell leukemia homeobox 3

chr7_+_157318477 5.216 ENST00000444154.1
AC006372.1
AC006372.1
chr6_-_4135693 4.829 ENST00000495548.1
ENST00000380125.2
ENST00000465828.1
ECI2


enoyl-CoA delta isomerase 2


chr19_+_8429031 4.829 ENST00000301455.2
ENST00000541807.1
ENST00000393962.2
ANGPTL4


angiopoietin-like 4


chr6_-_4135825 4.723 ENST00000380118.3
ENST00000413766.2
ENST00000361538.2
ECI2


enoyl-CoA delta isomerase 2


chr9_+_137218362 4.714 ENST00000481739.1
RXRA
retinoid X receptor, alpha
chr12_-_58131931 4.504 ENST00000547588.1
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr1_-_20812690 4.323 ENST00000375078.3
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr5_-_127873659 3.996 ENST00000262464.4
FBN2
fibrillin 2
chr19_-_19051927 3.765 ENST00000600077.1
HOMER3
homer homolog 3 (Drosophila)
chr8_+_86376081 3.763 ENST00000285379.5
CA2
carbonic anhydrase II
chr18_-_21242833 3.581 ENST00000586087.1
ENST00000592179.1
ANKRD29

ankyrin repeat domain 29

chr1_+_150522222 3.497 ENST00000369039.5
ADAMTSL4
ADAMTS-like 4
chr9_-_123639304 3.495 ENST00000436309.1
PHF19
PHD finger protein 19
chr10_-_79397391 3.465 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr1_-_9189229 3.369 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr2_-_72375167 3.323 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr11_-_568369 3.304 ENST00000534540.1
ENST00000528245.1
ENST00000500447.1
ENST00000533920.1
MIR210HG



MIR210 host gene (non-protein coding)



chr3_-_124774802 3.278 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,420 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.4 GO:0007386 compartment pattern specification(GO:0007386)
1.2 12.9 GO:0034465 response to carbon monoxide(GO:0034465)
0.4 12.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.2 12.1 GO:0061620 glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620)
0.4 9.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.4 9.6 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.7 9.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.4 8.8 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.5 8.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.8 7.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.7 7.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.7 6.8 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.5 6.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 6.1 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.1 6.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.8 6.0 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
1.0 5.9 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.5 5.9 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.4 5.8 GO:0051639 actin filament network formation(GO:0051639)
0.1 5.8 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 448 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.9 GO:0005924 cell-substrate adherens junction(GO:0005924)
0.2 19.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 18.4 GO:0005901 caveola(GO:0005901)
0.1 17.9 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 16.9 GO:0005730 nucleolus(GO:0005730)
0.2 14.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 12.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 11.9 GO:0030027 lamellipodium(GO:0030027)
0.4 10.7 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.5 10.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 9.2 GO:0001726 ruffle(GO:0001726)
0.2 8.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.2 8.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 8.4 GO:0005921 gap junction(GO:0005921)
0.1 8.1 GO:0005604 basement membrane(GO:0005604)
0.2 7.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 7.2 GO:0019898 extrinsic component of membrane(GO:0019898)
0.3 7.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 6.9 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
1.4 6.8 GO:0032449 CBM complex(GO:0032449)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 803 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 39.1 GO:0045296 cadherin binding(GO:0045296)
0.2 21.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 17.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 16.9 GO:0005096 GTPase activator activity(GO:0005096)
0.2 13.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 13.9 GO:0005178 integrin binding(GO:0005178)
1.5 12.1 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.3 11.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 9.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
2.4 9.4 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 9.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 9.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 9.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 8.7 GO:0002020 protease binding(GO:0002020)
0.2 8.3 GO:0003785 actin monomer binding(GO:0003785)
0.5 8.2 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.3 8.2 GO:0017166 vinculin binding(GO:0017166)
0.4 7.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 7.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 7.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 35.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 15.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 14.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 13.7 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 13.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 12.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 11.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.6 11.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.4 10.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 9.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 9.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 9.2 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.2 7.9 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 7.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 7.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 7.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 7.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 7.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 7.0 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.3 6.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 17.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 15.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 13.2 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.2 11.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 11.4 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.6 11.0 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.5 11.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.4 10.6 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 9.0 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.3 8.9 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 8.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 8.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 8.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 8.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 8.1 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.3 7.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.4 7.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 7.1 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 6.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events