Motif ID: YY1_YY2

Z-value: 0.904

Transcription factors associated with YY1_YY2:

Gene SymbolEntrez IDGene Name
YY1 ENSG00000100811.6 YY1
YY2 ENSG00000230797.2 YY2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
YY1hg19_v2_chr14_+_100705322_1007053600.252.3e-01Click!
YY2hg19_v2_chrX_+_21874105_218741050.058.3e-01Click!


Activity profile for motif YY1_YY2.

activity profile for motif YY1_YY2


Sorted Z-values histogram for motif YY1_YY2

Sorted Z-values for motif YY1_YY2



Network of associatons between targets according to the STRING database.



First level regulatory network of YY1_YY2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_87903079 2.868 ENST00000261622.4
 SLC7A5
solute carrier family 7 (amino acid transporter light chain, L system), member 5
chr16_+_30934376 2.165 ENST00000562798.1
ENST00000471231.2
 FBXL19

F-box and leucine-rich repeat protein 19

chr2_+_64681219 1.466 ENST00000238875.5
 LGALSL
lectin, galactoside-binding-like
chr14_+_75746781 1.427 ENST00000555347.1
 FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_190044480 1.391 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr18_+_21452964 1.304 ENST00000587184.1
 LAMA3
laminin, alpha 3
chr3_+_197677047 1.290 ENST00000448864.1
 RPL35A
ribosomal protein L35a
chr3_-_123304017 1.181 ENST00000383657.5
 PTPLB
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
chr20_+_25228669 1.175 ENST00000216962.4
 PYGB
phosphorylase, glycogen; brain
chr16_+_68877496 1.131 ENST00000261778.1
 TANGO6
transport and golgi organization 6 homolog (Drosophila)
chr18_+_21452804 1.123 ENST00000269217.6
 LAMA3
laminin, alpha 3
chr15_-_90039805 1.089 ENST00000544600.1
ENST00000268122.4
 RHCG

Rh family, C glycoprotein

chr19_-_13044494 1.078 ENST00000593021.1
ENST00000587981.1
ENST00000423140.2
ENST00000314606.4
 FARSA



phenylalanyl-tRNA synthetase, alpha subunit



chr3_-_52567792 1.073 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
 NT5DC2


5'-nucleotidase domain containing 2


chr9_+_131709966 1.073 ENST00000372577.2
 NUP188
nucleoporin 188kDa
chr6_+_151561506 1.064 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr5_-_149669192 1.058 ENST00000398376.3
 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr2_+_48667983 1.050 ENST00000449090.2
 PPP1R21
protein phosphatase 1, regulatory subunit 21
chr1_-_54303949 1.049 ENST00000234725.8
 NDC1
NDC1 transmembrane nucleoporin
chr16_+_30773636 1.039 ENST00000402121.3
ENST00000565995.1
ENST00000563683.1
ENST00000357890.5
ENST00000565931.1
 RNF40




ring finger protein 40, E3 ubiquitin protein ligase





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 532 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 5.5 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.5 3.9 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 3.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 3.5 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 3.2 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.1 2.7 GO:0006491 N-glycan processing(GO:0006491)
0.8 2.4 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 2.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 2.2 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 2.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 2.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 2.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 2.0 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 2.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.9 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 1.8 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2 1.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 1.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 4.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 3.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.4 3.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 3.0 GO:0015934 large ribosomal subunit(GO:0015934)
0.8 2.4 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 2.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.3 2.1 GO:0035976 AP1 complex(GO:0035976)
0.1 2.1 GO:0042555 MCM complex(GO:0042555)
0.1 2.1 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 2.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.2 2.0 GO:0005638 lamin filament(GO:0005638)
0.1 2.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 2.0 GO:0031941 filamentous actin(GO:0031941)
0.0 2.0 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.2 1.7 GO:0000796 condensin complex(GO:0000796)
0.0 1.7 GO:0043195 terminal bouton(GO:0043195)
0.2 1.6 GO:0097209 epidermal lamellar body(GO:0097209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 340 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 8.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 3.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 3.1 GO:0042605 peptide antigen binding(GO:0042605)
0.1 2.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 2.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 2.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.2 GO:0051015 actin filament binding(GO:0051015)
0.0 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.8 GO:0005549 odorant binding(GO:0005549)
0.0 1.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 1.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 1.6 GO:0008184 glycogen phosphorylase activity(GO:0008184)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 3.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.4 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 2.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.1 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 2.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.9 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.8 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.6 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.1 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 6.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 3.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 3.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 2.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.7 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 2.6 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.6 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.0 2.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.5 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 2.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 2.2 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 2.0 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.5 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery