Motif ID: ZBTB14

Z-value: 1.637


Transcription factors associated with ZBTB14:

Gene SymbolEntrez IDGene Name
ZBTB14 ENSG00000198081.6 ZBTB14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB14hg19_v2_chr18_-_5296001_52960450.331.2e-01Click!


Activity profile for motif ZBTB14.

activity profile for motif ZBTB14


Sorted Z-values histogram for motif ZBTB14

Sorted Z-values for motif ZBTB14



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_28113217 9.217 ENST00000444339.2
 RBKS
ribokinase
chr1_+_111888890 7.318 ENST00000369738.4
 PIFO
primary cilia formation
chr1_+_111889212 7.308 ENST00000369737.4
 PIFO
primary cilia formation
chr2_-_28113965 7.139 ENST00000302188.3
 RBKS
ribokinase
chr9_+_71320557 6.964 ENST00000541509.1
 PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr18_-_45935663 6.910 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
 ZBTB7C







zinc finger and BTB domain containing 7C







chr20_+_9049682 6.390 ENST00000334005.3
ENST00000378473.3
 PLCB4

phospholipase C, beta 4

chr2_-_99757977 5.930 ENST00000355053.4
 TSGA10
testis specific, 10
chr13_-_36705425 5.698 ENST00000255448.4
ENST00000360631.3
ENST00000379892.4
 DCLK1


doublecortin-like kinase 1


chr9_+_71320596 5.491 ENST00000265382.3
 PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr12_-_112450915 5.024 ENST00000437003.2
ENST00000552374.2
ENST00000550831.3
ENST00000354825.3
ENST00000549537.2
ENST00000355445.3
 TMEM116





transmembrane protein 116





chr1_-_223537475 4.681 ENST00000344029.6
ENST00000494793.2
ENST00000366878.4
ENST00000366877.3
 SUSD4



sushi domain containing 4



chr22_-_31741757 4.525 ENST00000215919.3
 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_99757876 4.278 ENST00000539964.1
ENST00000393482.3
 TSGA10

testis specific, 10

chr1_-_223537401 4.245 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
 SUSD4


sushi domain containing 4


chr20_-_62462566 4.100 ENST00000245663.4
ENST00000302995.2
 ZBTB46

zinc finger and BTB domain containing 46

chr11_-_6440283 3.978 ENST00000299402.6
ENST00000609360.1
ENST00000389906.2
ENST00000532020.2
 APBB1



amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)



chr11_+_71791849 3.926 ENST00000423494.2
ENST00000539587.1
ENST00000538478.1
ENST00000324866.7
ENST00000439209.1
 LRTOMT




leucine rich transmembrane and O-methyltransferase domain containing




chr6_+_31865552 3.641 ENST00000469372.1
ENST00000497706.1
 C2

complement component 2

chr20_-_39317868 3.560 ENST00000373313.2
 MAFB
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 340 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.3 16.4 GO:0019303 D-ribose catabolic process(GO:0019303)
0.6 12.8 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 10.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 8.9 GO:0030449 regulation of complement activation(GO:0030449)
0.2 7.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
2.5 7.6 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 7.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
2.3 7.0 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.5 6.7 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 6.6 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.8 6.5 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.5 6.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.3 6.0 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.2 5.2 GO:0016578 histone deubiquitination(GO:0016578)
0.6 5.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 4.4 GO:0018345 protein palmitoylation(GO:0018345)
0.4 4.3 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.3 4.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 4.1 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.1 4.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.9 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 10.1 GO:0031514 motile cilium(GO:0031514)
1.0 9.3 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 8.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 5.5 GO:0000786 nucleosome(GO:0000786)
0.1 5.4 GO:0036064 ciliary basal body(GO:0036064)
0.3 4.7 GO:0000124 SAGA complex(GO:0000124)
0.1 4.7 GO:0031941 filamentous actin(GO:0031941)
0.0 4.5 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
1.4 4.1 GO:0043291 RAVE complex(GO:0043291)
0.0 3.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 3.4 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.5 3.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 3.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 2.7 GO:0044294 dendritic growth cone(GO:0044294)
0.2 2.6 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.2 2.5 GO:0030991 intraciliary transport particle A(GO:0030991)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 16.4 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.3 14.5 GO:0048487 beta-tubulin binding(GO:0048487)
1.4 12.8 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
4.2 12.5 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 10.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 8.4 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 7.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 7.0 GO:0048156 tau protein binding(GO:0048156)
0.5 6.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.2 6.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 6.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 5.8 GO:0031489 myosin V binding(GO:0031489)
0.5 5.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 5.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.8 5.0 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.4 4.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 4.4 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 4.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 4.2 GO:0030332 cyclin binding(GO:0030332)
0.1 3.5 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.8 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 9.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 8.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 8.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 7.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 4.7 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 3.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.9 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 1.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 1.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.3 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.2 PID_ATM_PATHWAY ATM pathway
0.0 1.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 0.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 0.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 6.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 6.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 3.9 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.2 3.6 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.1 3.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 3.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 3.0 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 2.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.6 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 2.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.8 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.8 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.3 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC