Motif ID: ZBTB18

Z-value: 0.628


Transcription factors associated with ZBTB18:

Gene SymbolEntrez IDGene Name
ZBTB18 ENSG00000179456.9 ZBTB18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB18hg19_v2_chr1_+_244214577_244214593-0.835.7e-07Click!


Activity profile for motif ZBTB18.

activity profile for motif ZBTB18


Sorted Z-values histogram for motif ZBTB18

Sorted Z-values for motif ZBTB18



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB18

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_100770328 2.124 ENST00000223095.4
ENST00000445463.2
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr2_+_113885138 1.987 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr3_-_111314230 1.753 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr4_+_75311019 1.695 ENST00000502307.1
AREG
amphiregulin
chr4_+_75480629 1.689 ENST00000380846.3
AREGB
amphiregulin B
chr4_+_75310851 1.679 ENST00000395748.3
ENST00000264487.2
AREG

amphiregulin

chr9_+_125137565 1.548 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr21_+_30502806 1.291 ENST00000399928.1
ENST00000399926.1
MAP3K7CL

MAP3K7 C-terminal like

chr11_-_62323702 1.236 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr15_-_74501360 1.233 ENST00000323940.5
STRA6
stimulated by retinoic acid 6
chrX_+_99899180 1.097 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr19_-_36001113 1.035 ENST00000434389.1
DMKN
dermokine
chr2_+_33359687 0.998 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
LTBP1


latent transforming growth factor beta binding protein 1


chr2_+_33359646 0.954 ENST00000390003.4
ENST00000418533.2
LTBP1

latent transforming growth factor beta binding protein 1

chr22_-_37823468 0.937 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr19_-_36001286 0.901 ENST00000602679.1
ENST00000492341.2
ENST00000472252.2
ENST00000602781.1
ENST00000402589.2
ENST00000458071.1
ENST00000436012.1
ENST00000443640.1
ENST00000450261.1
ENST00000467637.1
ENST00000480502.1
ENST00000474928.1
ENST00000414866.2
ENST00000392206.2
ENST00000488892.1
DMKN














dermokine














chr17_-_41174424 0.859 ENST00000355653.3
VAT1
vesicle amine transport 1
chr8_-_49833978 0.820 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr11_-_5537920 0.807 ENST00000380184.1
UBQLNL
ubiquilin-like
chr11_-_34379546 0.787 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.4 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.7 2.1 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 2.0 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 2.0 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3 1.9 GO:1903575 cornified envelope assembly(GO:1903575)
0.5 1.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 1.5 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 1.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 1.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.1 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.9 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.2 0.8 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.8 GO:0097237 cellular response to toxic substance(GO:0097237)
0.4 0.7 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 0.7 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.7 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.7 GO:0006068 ethanol catabolic process(GO:0006068)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 2.0 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 2.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.2 GO:0043034 costamere(GO:0043034)
0.1 0.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.2 0.5 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.4 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.3 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.2 GO:0043219 myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 2.0 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.4 2.0 GO:0050436 microfibril binding(GO:0050436)
0.0 1.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.4 1.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.8 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 0.7 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.7 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.1 0.6 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.6 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 0.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.9 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 1.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.9 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.8 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.6 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 2.1 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.8 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.7 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.6 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.4 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 0.3 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling