Motif ID: ZBTB33_CHD2

Z-value: 2.232

Transcription factors associated with ZBTB33_CHD2:

Gene SymbolEntrez IDGene Name
CHD2 ENSG00000173575.14 CHD2
ZBTB33 ENSG00000177485.6 ZBTB33

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB33hg19_v2_chrX_+_119384607_1193847200.691.9e-04Click!
CHD2hg19_v2_chr15_+_93443419_93443580-0.537.2e-03Click!


Activity profile for motif ZBTB33_CHD2.

activity profile for motif ZBTB33_CHD2


Sorted Z-values histogram for motif ZBTB33_CHD2

Sorted Z-values for motif ZBTB33_CHD2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB33_CHD2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_7761013 21.809 ENST00000571846.1
 CYB5D1
cytochrome b5 domain containing 1
chr17_+_7761301 17.924 ENST00000332439.4
ENST00000570446.1
 CYB5D1

cytochrome b5 domain containing 1

chr10_-_75118611 7.793 ENST00000355577.3
ENST00000394865.1
ENST00000310715.3
ENST00000401621.2
 TTC18



tetratricopeptide repeat domain 18



chr22_+_45809560 7.732 ENST00000342894.3
ENST00000538017.1
 RIBC2

RIB43A domain with coiled-coils 2

chr10_-_75118471 7.714 ENST00000340329.3
 TTC18
tetratricopeptide repeat domain 18
chr3_+_108308513 7.283 ENST00000361582.3
 DZIP3
DAZ interacting zinc finger protein 3
chr2_-_207629997 7.225 ENST00000454776.2
 MDH1B
malate dehydrogenase 1B, NAD (soluble)
chrX_+_53449887 7.222 ENST00000375327.3
 RIBC1
RIB43A domain with coiled-coils 1
chr2_-_207630033 6.864 ENST00000449792.1
 MDH1B
malate dehydrogenase 1B, NAD (soluble)
chr2_-_99757977 6.798 ENST00000355053.4
 TSGA10
testis specific, 10
chr15_+_75287861 6.273 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
 SCAMP5







secretory carrier membrane protein 5







chrY_+_15016725 5.943 ENST00000336079.3
 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr11_+_71791849 5.083 ENST00000423494.2
ENST00000539587.1
ENST00000538478.1
ENST00000324866.7
ENST00000439209.1
 LRTOMT




leucine rich transmembrane and O-methyltransferase domain containing




chr17_+_7591639 5.009 ENST00000396463.2
 WRAP53
WD repeat containing, antisense to TP53
chr2_-_99757876 4.844 ENST00000539964.1
ENST00000393482.3
 TSGA10

testis specific, 10

chrX_+_53449805 4.826 ENST00000414955.2
 RIBC1
RIB43A domain with coiled-coils 1
chr17_+_7591747 4.516 ENST00000534050.1
 WRAP53
WD repeat containing, antisense to TP53
chr15_-_56757329 4.450 ENST00000260453.3
 MNS1
meiosis-specific nuclear structural 1
chr15_+_22833395 4.253 ENST00000283645.4
 TUBGCP5
tubulin, gamma complex associated protein 5
chr4_-_17812309 4.109 ENST00000382247.1
ENST00000536863.1
 DCAF16

DDB1 and CUL4 associated factor 16


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 249 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 14.8 GO:0006108 malate metabolic process(GO:0006108)
0.7 14.1 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 12.7 GO:0030031 cell projection assembly(GO:0030031)
3.6 10.7 GO:0032203 telomere formation via telomerase(GO:0032203)
0.2 10.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.9 7.7 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.1 7.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 7.3 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 6.3 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
1.5 6.0 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.2 4.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
1.1 4.2 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.2 4.1 GO:0070986 left/right axis specification(GO:0070986)
0.9 3.5 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.0 3.5 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.9 2.8 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.2 2.8 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 2.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 2.8 GO:0009060 aerobic respiration(GO:0009060)
0.0 2.8 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 12.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.4 11.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 11.6 GO:0031514 motile cilium(GO:0031514)
0.9 7.7 GO:0000923 equatorial microtubule organizing center(GO:0000923)
1.0 7.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 6.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 6.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 4.8 GO:0000786 nucleosome(GO:0000786)
0.4 4.6 GO:0097433 dense body(GO:0097433)
0.2 4.4 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 4.4 GO:0035770 ribonucleoprotein granule(GO:0035770)
0.0 4.3 GO:0030175 filopodium(GO:0030175)
0.1 4.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 3.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 3.5 GO:0005721 pericentric heterochromatin(GO:0005721)
1.1 3.2 GO:0001534 radial spoke(GO:0001534)
0.0 2.6 GO:0044450 microtubule organizing center part(GO:0044450)
0.6 2.5 GO:1990423 RZZ complex(GO:1990423)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 14.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
2.1 14.8 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.3 13.6 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 7.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.4 7.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 6.0 GO:0042805 actinin binding(GO:0042805)
0.4 5.7 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 4.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 4.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 3.9 GO:0004386 helicase activity(GO:0004386)
0.0 3.8 GO:0008017 microtubule binding(GO:0008017)
0.1 3.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 3.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 2.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 2.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.5 GO:0042393 histone binding(GO:0042393)
0.0 2.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 2.4 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.4 2.3 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.2 2.3 GO:0071933 Arp2/3 complex binding(GO:0071933)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.8 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 3.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 2.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.6 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 1.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.2 PID_ALK2_PATHWAY ALK2 signaling events
0.0 1.2 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.1 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.9 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 0.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.3 5.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 2.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.1 REACTOME_PHOSPHORYLATION_OF_THE_APC_C Genes involved in Phosphorylation of the APC/C
0.1 1.9 REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1 1.8 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.1 1.8 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.5 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.4 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.1 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling