Motif ID: ZBTB4

Z-value: 0.402


Transcription factors associated with ZBTB4:

Gene SymbolEntrez IDGene Name
ZBTB4 ENSG00000174282.7 ZBTB4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB4hg19_v2_chr17_-_7387524_7387597,
hg19_v2_chr17_-_7382834_7382855		0.184.0e-01Click!


Activity profile for motif ZBTB4.

activity profile for motif ZBTB4


Sorted Z-values histogram for motif ZBTB4

Sorted Z-values for motif ZBTB4



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_62104897 0.838 ENST00000415229.2
ENST00000535727.1
ENST00000301776.5
 ASRGL1


asparaginase like 1


chr11_+_86511549 0.783 ENST00000533902.2
 PRSS23
protease, serine, 23
chr19_-_9006766 0.502 ENST00000599436.1
 MUC16
mucin 16, cell surface associated
chr16_-_23724518 0.422 ENST00000457008.2
 ERN2
endoplasmic reticulum to nucleus signaling 2
chr12_+_6561190 0.412 ENST00000544021.1
ENST00000266556.7
 TAPBPL

TAP binding protein-like

chr8_-_71581377 0.320 ENST00000276590.4
ENST00000522447.1
 LACTB2

lactamase, beta 2

chrX_-_99665262 0.309 ENST00000373034.4
ENST00000255531.7
 PCDH19

protocadherin 19

chr15_-_77363513 0.306 ENST00000267970.4
 TSPAN3
tetraspanin 3
chr14_+_74417192 0.305 ENST00000554320.1
 COQ6
coenzyme Q6 monooxygenase
chr13_+_24734880 0.299 ENST00000382095.4
 SPATA13
spermatogenesis associated 13
chr1_-_203055129 0.286 ENST00000241651.4
 MYOG
myogenin (myogenic factor 4)
chr8_-_143851203 0.277 ENST00000521396.1
ENST00000317543.7
 LYNX1

Ly6/neurotoxin 1

chr1_+_65886262 0.241 ENST00000371065.4
 LEPROT
leptin receptor overlapping transcript
chr22_+_29279552 0.236 ENST00000544604.2
 ZNRF3
zinc and ring finger 3
chr10_-_53459319 0.233 ENST00000331173.4
 CSTF2T
cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
chr19_+_10131437 0.229 ENST00000587782.1
 RDH8
retinol dehydrogenase 8 (all-trans)
chrX_-_63425561 0.218 ENST00000374869.3
ENST00000330258.3
 AMER1

APC membrane recruitment protein 1

chr11_+_86511569 0.212 ENST00000441050.1
 PRSS23
protease, serine, 23
chr10_+_123922941 0.208 ENST00000360561.3
 TACC2
transforming, acidic coiled-coil containing protein 2
chr17_+_7487146 0.200 ENST00000396501.4
ENST00000584378.1
ENST00000423172.2
ENST00000579445.1
ENST00000585217.1
ENST00000581380.1
 MPDU1





mannose-P-dolichol utilization defect 1






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0006528 asparagine metabolic process(GO:0006528)
0.1 0.4 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.0 0.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.4 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.4 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.3 GO:1903862 regulation of muscle atrophy(GO:0014735) response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.3 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.2 GO:0060356 leucine import(GO:0060356)
0.0 0.2 GO:0038018 Wnt receptor catabolic process(GO:0038018) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.2 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.2 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.2 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.2 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.0 0.2 GO:0032328 alanine transport(GO:0032328)
0.0 0.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0098845 postsynaptic endosome(GO:0098845)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.0 0.1 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.1 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.0 0.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 0.8 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.3 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.0 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane