Motif ID: ZBTB49

Z-value: 0.592


Transcription factors associated with ZBTB49:

Gene SymbolEntrez IDGene Name
ZBTB49 ENSG00000168826.11 ZBTB49

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB49hg19_v2_chr4_+_4291924_4292011-0.341.0e-01Click!


Activity profile for motif ZBTB49.

activity profile for motif ZBTB49


Sorted Z-values histogram for motif ZBTB49

Sorted Z-values for motif ZBTB49



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB49

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51466681 4.977 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr2_+_95691445 3.346 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
 MAL


mal, T-cell differentiation protein


chr2_+_95691417 3.051 ENST00000309988.4
 MAL
mal, T-cell differentiation protein
chr15_+_90728145 2.849 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
 SEMA4B


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B


chr10_-_90751038 1.547 ENST00000458159.1
ENST00000415557.1
ENST00000458208.1
 ACTA2


actin, alpha 2, smooth muscle, aorta


chr10_+_94352956 1.531 ENST00000260731.3
 KIF11
kinesin family member 11
chr15_+_75639773 1.245 ENST00000567657.1
 NEIL1
nei endonuclease VIII-like 1 (E. coli)
chrX_+_64887512 1.221 ENST00000360270.5
 MSN
moesin
chr3_-_196756646 1.201 ENST00000439320.1
ENST00000296351.4
ENST00000296350.5
 MFI2


antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5


chr22_-_37915247 1.103 ENST00000251973.5
 CARD10
caspase recruitment domain family, member 10
chr17_-_80009650 0.975 ENST00000310496.4
 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_+_35591858 0.955 ENST00000603544.1
 KIAA0391
KIAA0391
chr17_-_74582191 0.879 ENST00000225276.5
 ST6GALNAC2
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr11_+_117857063 0.860 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
 IL10RA


interleukin 10 receptor, alpha


chr1_-_110933663 0.815 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
 SLC16A4


solute carrier family 16, member 4


chr6_-_109777128 0.804 ENST00000358807.3
ENST00000358577.3
 MICAL1

microtubule associated monooxygenase, calponin and LIM domain containing 1

chr9_+_139553306 0.749 ENST00000371699.1
 EGFL7
EGF-like-domain, multiple 7
chr1_-_110933611 0.746 ENST00000472422.2
ENST00000437429.2
 SLC16A4

solute carrier family 16, member 4

chr8_-_82024290 0.735 ENST00000220597.4
 PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr6_-_49604545 0.668 ENST00000371175.4
ENST00000229810.7
 RHAG

Rh-associated glycoprotein


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.4 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.2 5.0 GO:0016540 protein autoprocessing(GO:0016540)
0.0 2.8 GO:0050919 negative chemotaxis(GO:0050919)
0.2 2.0 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.3 1.5 GO:0090131 mesenchyme migration(GO:0090131)
0.1 1.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.2 1.3 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 1.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 1.1 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 1.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 0.9 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 0.9 GO:0097503 sialylation(GO:0097503)
0.3 0.8 GO:0019417 sulfur oxidation(GO:0019417)
0.2 0.7 GO:0035378 carbon dioxide transmembrane transport(GO:0035378)
0.1 0.7 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.7 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.1 0.6 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.6 GO:0051764 actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.3 2.0 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.3 1.5 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.1 1.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 1.1 GO:0032449 CBM complex(GO:0032449)
0.0 1.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.7 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.3 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 5.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 2.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.4 1.1 GO:0038131 neuregulin receptor activity(GO:0038131)
0.2 1.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 1.0 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 0.9 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.9 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.9 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.8 GO:0071949 FAD binding(GO:0071949)
0.2 0.7 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.1 0.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.6 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 2.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.1 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.5 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.3 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.9 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR