Motif ID: ZBTB6

Z-value: 1.023


Transcription factors associated with ZBTB6:

Gene SymbolEntrez IDGene Name
ZBTB6 ENSG00000186130.4 ZBTB6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB6hg19_v2_chr9_-_125675576_125675612-0.058.3e-01Click!


Activity profile for motif ZBTB6.

activity profile for motif ZBTB6


Sorted Z-values histogram for motif ZBTB6

Sorted Z-values for motif ZBTB6



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_41827594 4.365 ENST00000372591.1
 FOXO6
forkhead box O6
chr21_-_43916433 3.216 ENST00000291536.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr21_-_43916296 3.059 ENST00000398352.3
 RSPH1
radial spoke head 1 homolog (Chlamydomonas)
chr17_+_1633755 2.547 ENST00000545662.1
 WDR81
WD repeat domain 81
chr19_+_54058073 2.405 ENST00000505949.1
ENST00000513265.1
 ZNF331

zinc finger protein 331

chr16_-_52580920 2.170 ENST00000219746.9
 TOX3
TOX high mobility group box family member 3
chr3_-_197686847 1.921 ENST00000265239.6
 IQCG
IQ motif containing G
chr19_-_55672037 1.915 ENST00000588076.1
 DNAAF3
dynein, axonemal, assembly factor 3
chr4_-_7044657 1.843 ENST00000310085.4
 CCDC96
coiled-coil domain containing 96
chr19_-_55677920 1.715 ENST00000524407.2
ENST00000526003.1
ENST00000534170.1
 DNAAF3


dynein, axonemal, assembly factor 3


chr11_+_46299199 1.706 ENST00000529193.1
ENST00000288400.3
 CREB3L1

cAMP responsive element binding protein 3-like 1

chr19_-_55677999 1.681 ENST00000532817.1
ENST00000527223.2
ENST00000391720.4
 DNAAF3


dynein, axonemal, assembly factor 3


chr15_+_71185148 1.643 ENST00000443425.2
ENST00000560755.1
 LRRC49

leucine rich repeat containing 49

chr21_+_36041688 1.610 ENST00000360731.3
ENST00000349499.2
 CLIC6

chloride intracellular channel 6

chr1_-_223537401 1.585 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
 SUSD4


sushi domain containing 4


chr9_+_71320557 1.573 ENST00000541509.1
 PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr13_-_26625169 1.564 ENST00000319420.3
 SHISA2
shisa family member 2
chr14_-_61190754 1.550 ENST00000216513.4
 SIX4
SIX homeobox 4
chr13_+_35516390 1.542 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr20_-_33460621 1.503 ENST00000427420.1
ENST00000336431.5
 GGT7

gamma-glutamyltransferase 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 245 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 2.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 2.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 2.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 2.1 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 2.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 1.9 GO:0072313 metanephric glomerular epithelium development(GO:0072244) metanephric glomerular visceral epithelial cell differentiation(GO:0072248) metanephric glomerular visceral epithelial cell development(GO:0072249) metanephric glomerular epithelial cell differentiation(GO:0072312) metanephric glomerular epithelial cell development(GO:0072313)
0.1 1.8 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.3 1.7 GO:0048880 sensory system development(GO:0048880)
0.2 1.7 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.0 1.7 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 1.7 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.1 1.6 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.2 1.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 1.5 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.5 1.4 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 1.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 1.3 GO:0010226 response to lithium ion(GO:0010226)
0.0 1.3 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 1.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 6.3 GO:0072687 meiotic spindle(GO:0072687)
0.1 3.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 2.6 GO:0097542 ciliary tip(GO:0097542)
0.0 2.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 1.9 GO:0005608 laminin-3 complex(GO:0005608)
0.3 1.9 GO:0002177 manchette(GO:0002177)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.4 GO:0016235 aggresome(GO:0016235)
0.0 1.4 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.3 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.2 1.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 1.0 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.0 1.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 0.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 0.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.2 0.8 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 0.8 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.8 2.5 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.2 2.2 GO:0034056 estrogen response element binding(GO:0034056)
0.3 2.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 2.0 GO:0031489 myosin V binding(GO:0031489)
0.1 1.9 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 1.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.3 1.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 1.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.4 1.3 GO:0070260 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.2 1.2 GO:0045118 azole transporter activity(GO:0045118)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.1 GO:0005537 mannose binding(GO:0005537)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 2.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.0 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.8 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 0.8 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 REACTOME_GENERIC_TRANSCRIPTION_PATHWAY Genes involved in Generic Transcription Pathway
0.1 3.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 2.2 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 1.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 1.2 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 1.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.9 REACTOME_FGFR_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.9 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.9 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions