Motif ID: ZBTB7A_ZBTB7C
Z-value: 0.619
Transcription factors associated with ZBTB7A_ZBTB7C:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ZBTB7A | ENSG00000178951.4 | ZBTB7A |
| ZBTB7C | ENSG00000184828.5 | ZBTB7C |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZBTB7C | hg19_v2_chr18_-_45935663_45935793, hg19_v2_chr18_-_45663666_45663732 | 0.73 | 5.0e-05 | Click! |
| ZBTB7A | hg19_v2_chr19_-_4066890_4066943 | -0.55 | 5.7e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.5 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.8 | 2.3 | GO:1903410 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 0.4 | 1.1 | GO:1904924 | negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924) |
| 0.3 | 0.9 | GO:0060129 | thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034) |
| 0.3 | 1.5 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.2 | 0.5 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.1 | 0.6 | GO:0006145 | purine nucleobase catabolic process(GO:0006145) |
| 0.1 | 0.5 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
| 0.1 | 1.1 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.1 | 0.7 | GO:0061055 | myotome development(GO:0061055) |
| 0.1 | 0.3 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 0.1 | 0.3 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.1 | 0.6 | GO:0001757 | somite specification(GO:0001757) |
| 0.1 | 0.3 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.1 | 0.3 | GO:0010621 | negative regulation of transcription by transcription factor localization(GO:0010621) |
| 0.1 | 0.3 | GO:2001226 | negative regulation of chloride transport(GO:2001226) |
| 0.1 | 0.2 | GO:0032289 | central nervous system myelin formation(GO:0032289) |
| 0.1 | 0.2 | GO:0002949 | tRNA threonylcarbamoyladenosine modification(GO:0002949) |
| 0.1 | 0.4 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.1 | 0.5 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.1 | 2.8 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.1 | 0.3 | GO:0034154 | toll-like receptor 7 signaling pathway(GO:0034154) |
| 0.1 | 0.2 | GO:0090310 | negative regulation of methylation-dependent chromatin silencing(GO:0090310) |
| 0.1 | 0.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.0 | 0.5 | GO:0072718 | response to cisplatin(GO:0072718) |
| 0.0 | 0.2 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.0 | 0.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.1 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.0 | 0.1 | GO:0072053 | renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) inner medullary collecting duct development(GO:0072061) |
| 0.0 | 0.2 | GO:1901675 | response to methylglyoxal(GO:0051595) negative regulation of histone H3-K27 acetylation(GO:1901675) |
| 0.0 | 0.5 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) |
| 0.0 | 0.6 | GO:0060907 | positive regulation of macrophage cytokine production(GO:0060907) |
| 0.0 | 0.2 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.0 | 0.1 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.1 | GO:0030860 | regulation of polarized epithelial cell differentiation(GO:0030860) |
| 0.0 | 0.2 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) |
| 0.0 | 0.1 | GO:0035494 | SNARE complex disassembly(GO:0035494) |
| 0.0 | 0.1 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.0 | 0.6 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 0.0 | 0.1 | GO:0032240 | negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.0 | 0.1 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
| 0.0 | 1.5 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.2 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.0 | 0.1 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.0 | 0.4 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
| 0.0 | 0.5 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.1 | GO:2000302 | regulation of synaptic vesicle priming(GO:0010807) positive regulation of synaptic vesicle exocytosis(GO:2000302) |
| 0.0 | 0.3 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.0 | 0.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.2 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.0 | 0.4 | GO:0021694 | cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702) |
| 0.0 | 0.6 | GO:1904886 | beta-catenin destruction complex disassembly(GO:1904886) |
| 0.0 | 1.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.5 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 0.1 | GO:0002572 | pro-T cell differentiation(GO:0002572) |
| 0.0 | 0.4 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.0 | 0.1 | GO:1900454 | positive regulation of long term synaptic depression(GO:1900454) |
| 0.0 | 0.2 | GO:0061740 | protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740) |
| 0.0 | 0.1 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 0.0 | 0.4 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 0.1 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.0 | 0.1 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.0 | 0.1 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) |
| 0.0 | 0.0 | GO:0090598 | male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598) |
| 0.0 | 0.7 | GO:0060384 | innervation(GO:0060384) |
| 0.0 | 0.1 | GO:1903936 | response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936) |
| 0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.0 | 0.3 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.0 | 0.1 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.0 | 0.0 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.5 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 0.7 | GO:0000836 | Hrd1p ubiquitin ligase complex(GO:0000836) |
| 0.1 | 0.6 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 0.2 | GO:0032302 | MutSbeta complex(GO:0032302) |
| 0.1 | 0.5 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 0.2 | GO:0031166 | integral component of vacuolar membrane(GO:0031166) |
| 0.0 | 0.1 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679) |
| 0.0 | 0.5 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 0.2 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 0.3 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 1.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.2 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 1.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.1 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.0 | 0.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.1 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.0 | 0.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.5 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.1 | GO:1990742 | microvesicle(GO:1990742) |
| 0.0 | 0.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.1 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.1 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.1 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.5 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.3 | GO:0005289 | high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292) |
| 0.2 | 12.4 | GO:0042805 | actinin binding(GO:0042805) |
| 0.2 | 0.5 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.1 | 0.5 | GO:0016215 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.1 | 0.6 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.1 | 0.4 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 0.1 | 1.5 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 0.3 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.1 | 1.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.5 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 0.2 | GO:0000404 | heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
| 0.1 | 2.8 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 0.3 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.1 | 0.4 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.1 | 0.2 | GO:0070579 | methylcytosine dioxygenase activity(GO:0070579) |
| 0.0 | 0.1 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.1 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.0 | 0.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.1 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.0 | 0.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 1.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.1 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.0 | 0.2 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 0.8 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 0.5 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 1.0 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.1 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.2 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 0.3 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.0 | 0.1 | GO:0005483 | soluble NSF attachment protein activity(GO:0005483) |
| 0.0 | 0.1 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.0 | 0.2 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 0.2 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.4 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.2 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.0 | 0.1 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.3 | GO:0035325 | Toll-like receptor binding(GO:0035325) |
| 0.0 | 0.3 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.6 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.4 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.4 | PID_S1P_S1P2_PATHWAY | S1P2 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 5.0 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 0.8 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.0 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.6 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.7 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.4 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.0 | 0.8 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.6 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.4 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 1.3 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.4 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
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