Motif ID: ZBTB7A_ZBTB7C

Z-value: 0.619

Transcription factors associated with ZBTB7A_ZBTB7C:

Gene SymbolEntrez IDGene Name
ZBTB7A ENSG00000178951.4 ZBTB7A
ZBTB7C ENSG00000184828.5 ZBTB7C

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB7Chg19_v2_chr18_-_45935663_45935793,
hg19_v2_chr18_-_45663666_45663732		0.735.0e-05Click!
ZBTB7Ahg19_v2_chr19_-_4066890_4066943-0.555.7e-03Click!


Activity profile for motif ZBTB7A_ZBTB7C.

activity profile for motif ZBTB7A_ZBTB7C


Sorted Z-values histogram for motif ZBTB7A_ZBTB7C

Sorted Z-values for motif ZBTB7A_ZBTB7C



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB7A_ZBTB7C

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_16085340 6.275 ENST00000508167.1
 PROM1
prominin 1
chr4_-_16085314 6.248 ENST00000510224.1
 PROM1
prominin 1
chr1_+_205538105 2.046 ENST00000367147.4
ENST00000539267.1
 MFSD4

major facilitator superfamily domain containing 4

chr17_-_1532106 1.690 ENST00000301335.5
ENST00000382147.4
 SLC43A2

solute carrier family 43 (amino acid system L transporter), member 2

chr12_+_50355647 1.507 ENST00000293599.6
 AQP5
aquaporin 5
chr5_+_76506706 1.453 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
 PDE8B




phosphodiesterase 8B




chr8_+_17354617 1.225 ENST00000470360.1
 SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr17_-_1531635 1.063 ENST00000571650.1
 SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr8_+_17354587 1.042 ENST00000494857.1
ENST00000522656.1
 SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr1_-_22469459 0.905 ENST00000290167.6
 WNT4
wingless-type MMTV integration site family, member 4
chr13_+_96204961 0.870 ENST00000299339.2
 CLDN10
claudin 10
chr4_+_72052964 0.784 ENST00000264485.5
ENST00000425175.1
 SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr15_-_62352659 0.721 ENST00000249837.3
 VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr15_+_27112948 0.700 ENST00000555060.1
 GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr9_-_123476612 0.687 ENST00000426959.1
 MEGF9
multiple EGF-like-domains 9
chr3_+_108308513 0.668 ENST00000361582.3
 DZIP3
DAZ interacting zinc finger protein 3
chr7_+_26191809 0.654 ENST00000056233.3
 NFE2L3
nuclear factor, erythroid 2-like 3
chr16_-_19896220 0.649 ENST00000562469.1
ENST00000300571.2
 GPRC5B

G protein-coupled receptor, family C, group 5, member B

chr5_+_149109825 0.633 ENST00000360453.4
ENST00000394320.3
ENST00000309241.5
 PPARGC1B


peroxisome proliferator-activated receptor gamma, coactivator 1 beta


chr7_-_51384451 0.617 ENST00000441453.1
ENST00000265136.7
ENST00000395542.2
ENST00000395540.2
 COBL



cordon-bleu WH2 repeat protein




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 12.5 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.1 2.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.8 2.3 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.3 1.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 1.5 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 1.3 GO:0015701 bicarbonate transport(GO:0015701)
0.4 1.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1 1.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.3 0.9 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) renal vesicle induction(GO:0072034)
0.0 0.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0061055 myotome development(GO:0061055)
0.0 0.7 GO:0060384 innervation(GO:0060384)
0.1 0.6 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 0.6 GO:0001757 somite specification(GO:0001757)
0.0 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.6 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.6 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.2 0.5 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.5 GO:1902361 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
0.1 0.5 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 12.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.7 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.6 GO:0044294 dendritic growth cone(GO:0044294)
0.1 0.5 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.5 GO:0032009 early phagosome(GO:0032009)
0.0 0.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.1 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.2 GO:0071817 MMXD complex(GO:0071817)
0.0 0.2 GO:0001673 male germ cell nucleus(GO:0001673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 GO:0042805 actinin binding(GO:0042805)
0.1 2.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.6 2.3 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.1 1.5 GO:0015250 water channel activity(GO:0015250)
0.0 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.8 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.6 GO:0019239 deaminase activity(GO:0019239)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.1 0.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 0.4 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 0.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR