Motif ID: ZEB1

Z-value: 1.780


Transcription factors associated with ZEB1:

Gene SymbolEntrez IDGene Name
ZEB1 ENSG00000148516.17 ZEB1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZEB1hg19_v2_chr10_+_31610064_31610159-0.546.3e-03Click!


Activity profile for motif ZEB1.

activity profile for motif ZEB1


Sorted Z-values histogram for motif ZEB1

Sorted Z-values for motif ZEB1



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51471362 8.228 ENST00000376853.4
ENST00000424910.2
 KLK6

kallikrein-related peptidase 6

chr19_-_51471381 8.140 ENST00000594641.1
 KLK6
kallikrein-related peptidase 6
chr19_-_51504411 6.536 ENST00000593490.1
 KLK8
kallikrein-related peptidase 8
chr13_-_20806440 5.698 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
 GJB6


gap junction protein, beta 6, 30kDa


chr4_-_57522470 4.281 ENST00000503639.3
 HOPX
HOP homeobox
chr11_-_65667997 3.761 ENST00000312562.2
ENST00000534222.1
 FOSL1

FOS-like antigen 1

chr4_+_75311019 3.486 ENST00000502307.1
 AREG
amphiregulin
chr14_+_75745477 3.435 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
 FOS




FBJ murine osteosarcoma viral oncogene homolog




chr4_+_75310851 3.345 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr1_+_183155373 3.299 ENST00000493293.1
ENST00000264144.4
 LAMC2

laminin, gamma 2

chr14_-_75422280 3.296 ENST00000238607.6
ENST00000553716.1
 PGF

placental growth factor

chr11_-_65667884 3.262 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
 FOSL1


FOS-like antigen 1


chr4_+_75480629 3.258 ENST00000380846.3
 AREGB
amphiregulin B
chr1_+_152956549 3.197 ENST00000307122.2
 SPRR1A
small proline-rich protein 1A
chr3_-_50336548 3.189 ENST00000513170.1
ENST00000450982.1
ENST00000450489.1
 HYAL3

NAT6
hyaluronoglucosaminidase 3

N-acetyltransferase 6 (GCN5-related)
chr19_-_51472222 3.168 ENST00000376851.3
 KLK6
kallikrein-related peptidase 6
chr19_+_54926621 3.118 ENST00000376530.3
ENST00000445095.1
ENST00000391739.3
ENST00000376531.3
 TTYH1



tweety family member 1



chr19_-_51472031 3.010 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_+_54926601 2.997 ENST00000301194.4
 TTYH1
tweety family member 1
chr2_+_234104079 2.982 ENST00000417661.1
 INPP5D
inositol polyphosphate-5-phosphatase, 145kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 827 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 23.6 GO:0016540 protein autoprocessing(GO:0016540)
0.1 13.1 GO:0070268 cornification(GO:0070268)
0.9 8.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
1.0 7.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 7.9 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 7.6 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.9 7.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
1.2 7.0 GO:0007296 vitellogenesis(GO:0007296)
0.5 7.0 GO:0071493 cellular response to UV-B(GO:0071493)
0.9 6.8 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.3 6.8 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 6.6 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.8 6.5 GO:0031642 negative regulation of myelination(GO:0031642)
0.4 6.4 GO:0035878 nail development(GO:0035878)
0.3 6.3 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.3 5.9 GO:0070831 basement membrane assembly(GO:0070831)
0.1 5.9 GO:0051602 response to electrical stimulus(GO:0051602)
0.1 5.8 GO:0007520 myoblast fusion(GO:0007520)
0.2 5.7 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
1.3 5.3 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 308 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 38.7 GO:0005730 nucleolus(GO:0005730)
0.3 21.7 GO:0001533 cornified envelope(GO:0001533)
0.1 11.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.5 10.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 8.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
1.0 7.8 GO:0035976 AP1 complex(GO:0035976)
0.0 7.6 GO:0005925 focal adhesion(GO:0005925)
0.3 7.5 GO:0005922 connexon complex(GO:0005922)
0.1 7.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 6.6 GO:0001726 ruffle(GO:0001726)
0.0 6.4 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.7 6.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1 6.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.1 6.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 6.2 GO:0005882 intermediate filament(GO:0005882)
0.0 5.3 GO:0072562 blood microparticle(GO:0072562)
0.1 5.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 5.1 GO:0031941 filamentous actin(GO:0031941)
0.1 5.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 5.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 498 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 36.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 16.2 GO:0045296 cadherin binding(GO:0045296)
0.1 12.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 12.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 11.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.9 8.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 7.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 7.0 GO:0070412 R-SMAD binding(GO:0070412)
0.1 6.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.6 6.2 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.6 6.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 5.9 GO:0003785 actin monomer binding(GO:0003785)
1.0 5.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 5.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 5.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.4 5.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.2 5.1 GO:0031005 filamin binding(GO:0031005)
1.0 5.0 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
1.0 5.0 GO:0050473 arachidonate 15-lipoxygenase activity(GO:0050473)
0.4 4.9 GO:0038132 neuregulin binding(GO:0038132)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 29.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 20.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 14.0 PID_LKB1_PATHWAY LKB1 signaling events
0.5 12.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 10.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 7.8 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 7.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 7.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 7.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 6.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 6.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 5.9 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 5.7 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.2 4.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 4.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.2 4.5 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 4.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.2 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 4.1 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.1 3.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.1 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 12.5 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.5 9.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 9.9 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 8.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 7.5 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 7.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 6.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 6.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 6.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.7 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 5.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.1 5.4 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 5.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 4.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.1 4.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 4.2 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 3.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane