Motif ID: ZIC1

Z-value: 0.681


Transcription factors associated with ZIC1:

Gene SymbolEntrez IDGene Name
ZIC1 ENSG00000152977.5 ZIC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZIC1hg19_v2_chr3_+_147127142_1471271710.106.5e-01Click!


Activity profile for motif ZIC1.

activity profile for motif ZIC1


Sorted Z-values histogram for motif ZIC1

Sorted Z-values for motif ZIC1



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_39203519 0.898 ENST00000542137.1
ENST00000391419.3
 KRTAP2-1

keratin associated protein 2-1

chr3_-_58563094 0.649 ENST00000464064.1
 FAM107A
family with sequence similarity 107, member A
chr11_-_2182388 0.644 ENST00000397270.1
ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
 INS-IGF2
INS



INS-IGF2 readthrough
insulin



chr6_-_35656685 0.598 ENST00000539068.1
ENST00000540787.1
 FKBP5

FK506 binding protein 5

chr1_-_177134024 0.582 ENST00000367654.3
 ASTN1
astrotactin 1
chr6_-_35656712 0.561 ENST00000357266.4
ENST00000542713.1
 FKBP5

FK506 binding protein 5

chr16_-_31100284 0.441 ENST00000280606.6
 PRSS53
protease, serine, 53
chr22_-_24622080 0.419 ENST00000425408.1
 GGT5
gamma-glutamyltransferase 5
chr10_+_118350468 0.408 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1


pancreatic lipase-related protein 1


chr16_-_755819 0.387 ENST00000397621.1
 FBXL16
F-box and leucine-rich repeat protein 16
chr1_+_1567474 0.373 ENST00000356026.5
 MMP23B
matrix metallopeptidase 23B
chr7_-_37026108 0.372 ENST00000396045.3
 ELMO1
engulfment and cell motility 1
chr1_+_1567546 0.362 ENST00000378675.3
 MMP23B
matrix metallopeptidase 23B
chr17_-_39216344 0.343 ENST00000391418.2
 KRTAP2-3
keratin associated protein 2-3
chr13_-_29069232 0.339 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
 FLT1


fms-related tyrosine kinase 1


chr1_+_16348366 0.333 ENST00000375692.1
ENST00000420078.1
 CLCNKA

chloride channel, voltage-sensitive Ka

chr8_+_85097110 0.332 ENST00000517638.1
ENST00000522647.1
 RALYL

RALY RNA binding protein-like

chr19_-_8213753 0.332 ENST00000601739.1
 FBN3
fibrillin 3
chr19_+_45409011 0.321 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
 APOE


apolipoprotein E


chr10_+_118350522 0.316 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1



pancreatic lipase-related protein 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0031424 keratinization(GO:0031424)
0.0 1.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.8 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.2 0.6 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0 0.6 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.5 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.5 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.3 GO:2000646 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of receptor catabolic process(GO:2000646)
0.1 0.3 GO:0007538 primary sex determination(GO:0007538)
0.1 0.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.1 0.3 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.3 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
0.0 0.3 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.3 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.1 0.2 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.6 GO:0031904 endosome lumen(GO:0031904)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0034709 methylosome(GO:0034709)
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.2 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.2 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:1901612 cardiolipin binding(GO:1901612)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME_PROSTANOID_LIGAND_RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics