Motif ID: ZIC2_GLI1

Z-value: 0.697

Transcription factors associated with ZIC2_GLI1:

Gene SymbolEntrez IDGene Name
GLI1 ENSG00000111087.5 GLI1
ZIC2 ENSG00000043355.6 ZIC2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GLI1hg19_v2_chr12_+_57857475_57857475,
hg19_v2_chr12_+_57853918_57853934		-0.359.6e-02Click!
ZIC2hg19_v2_chr13_+_100634004_1006340260.087.3e-01Click!


Activity profile for motif ZIC2_GLI1.

activity profile for motif ZIC2_GLI1


Sorted Z-values histogram for motif ZIC2_GLI1

Sorted Z-values for motif ZIC2_GLI1



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC2_GLI1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_163148973 3.060 ENST00000366888.2
 PACRG
PARK2 co-regulated
chr9_-_34397800 2.247 ENST00000297623.2
 C9orf24
chromosome 9 open reading frame 24
chr22_-_50970506 1.668 ENST00000428989.2
ENST00000403326.1
 ODF3B

outer dense fiber of sperm tails 3B

chrX_+_152240819 1.516 ENST00000535416.1
ENST00000421798.3
 PNMA6A
PNMA6C
paraneoplastic Ma antigen family member 6A
paraneoplastic Ma antigen family member 6C
chr22_-_50970566 1.291 ENST00000405135.1
ENST00000401779.1
 ODF3B

outer dense fiber of sperm tails 3B

chr9_+_131218698 1.224 ENST00000434106.3
ENST00000546203.1
ENST00000446274.1
ENST00000421776.2
ENST00000432065.2
 ODF2




outer dense fiber of sperm tails 2




chr15_-_93616892 1.097 ENST00000556658.1
ENST00000538818.1
ENST00000425933.2
 RGMA


repulsive guidance molecule family member a


chr22_-_50970919 1.065 ENST00000329363.4
ENST00000437588.1
 ODF3B

outer dense fiber of sperm tails 3B

chr15_-_78526855 1.025 ENST00000541759.1
ENST00000558130.1
 ACSBG1

acyl-CoA synthetase bubblegum family member 1

chr1_+_47264711 1.011 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr6_-_29595779 0.973 ENST00000355973.3
ENST00000377012.4
 GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr9_+_131219179 0.972 ENST00000372791.3
 ODF2
outer dense fiber of sperm tails 2
chr9_+_131218408 0.963 ENST00000351030.3
ENST00000604420.1
ENST00000535026.1
ENST00000448249.3
ENST00000393527.3
 ODF2




outer dense fiber of sperm tails 2




chr2_-_28113965 0.963 ENST00000302188.3
 RBKS
ribokinase
chr16_+_75256507 0.869 ENST00000495583.1
 CTRB1
chymotrypsinogen B1
chr12_-_25801478 0.823 ENST00000540106.1
ENST00000445693.1
ENST00000545543.1
ENST00000542224.1
 IFLTD1



intermediate filament tail domain containing 1



chr9_+_131218336 0.743 ENST00000372814.3
 ODF2
outer dense fiber of sperm tails 2
chr20_+_57430162 0.717 ENST00000450130.1
ENST00000349036.3
ENST00000423897.1
 GNAS


GNAS complex locus


chr11_-_75379612 0.689 ENST00000526740.1
 MAP6
microtubule-associated protein 6
chr3_-_52486841 0.668 ENST00000496590.1
 TNNC1
troponin C type 1 (slow)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0007286 spermatid development(GO:0007286)
0.0 1.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 1.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 1.1 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 1.1 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 1.0 GO:0019303 D-ribose catabolic process(GO:0019303)
0.1 1.0 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.9 GO:0009235 cobalamin metabolic process(GO:0009235)
0.1 0.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.2 0.7 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.1 0.7 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 0.6 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.6 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.2 0.5 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.4 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0033578 protein glycosylation in Golgi(GO:0033578)
0.0 0.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.4 GO:0016198 axon choice point recognition(GO:0016198)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.9 GO:0001520 outer dense fiber(GO:0001520)
0.1 3.1 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.2 GO:0097512 cardiac myofibril(GO:0097512)
0.4 1.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.7 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.3 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.1 0.2 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0032279 asymmetric synapse(GO:0032279)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.3 1.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 1.1 GO:1990459 transferrin receptor binding(GO:1990459)
0.1 1.0 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.0 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.7 GO:0031013 troponin I binding(GO:0031013)
0.1 0.7 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.6 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 0.4 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.3 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.3 GO:0070404 NADH binding(GO:0070404)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.7 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.2 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly