Motif ID: ZIC3_ZIC4

Z-value: 0.428

Transcription factors associated with ZIC3_ZIC4:

Gene SymbolEntrez IDGene Name
ZIC3 ENSG00000156925.7 ZIC3
ZIC4 ENSG00000174963.13 ZIC4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZIC4hg19_v2_chr3_-_147124547_1471246470.537.8e-03Click!
ZIC3hg19_v2_chrX_+_136648297_1366483190.001.0e+00Click!


Activity profile for motif ZIC3_ZIC4.

activity profile for motif ZIC3_ZIC4


Sorted Z-values histogram for motif ZIC3_ZIC4

Sorted Z-values for motif ZIC3_ZIC4



Network of associatons between targets according to the STRING database.



First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_1711918 0.903 ENST00000331222.4
 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr5_-_180018540 0.730 ENST00000292641.3
 SCGB3A1
secretoglobin, family 3A, member 1
chr13_+_35516390 0.724 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
 NBEA


neurobeachin


chr5_+_76506706 0.684 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
 PDE8B




phosphodiesterase 8B




chr4_-_149363662 0.626 ENST00000355292.3
ENST00000358102.3
 NR3C2

nuclear receptor subfamily 3, group C, member 2

chr2_-_99552620 0.559 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
 KIAA1211L


KIAA1211-like


chr2_+_8822113 0.558 ENST00000396290.1
ENST00000331129.3
 ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr17_-_74137374 0.525 ENST00000322957.6
 FOXJ1
forkhead box J1
chr1_-_32801825 0.514 ENST00000329421.7
 MARCKSL1
MARCKS-like 1
chr20_+_35201857 0.498 ENST00000373874.2
 TGIF2
TGFB-induced factor homeobox 2
chr14_+_100848311 0.447 ENST00000542471.2
 WDR25
WD repeat domain 25
chr9_-_124989804 0.443 ENST00000373755.2
ENST00000373754.2
 LHX6

LIM homeobox 6

chr19_+_13135731 0.428 ENST00000587260.1
 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_+_73676281 0.410 ENST00000543947.1
 DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr20_+_35201993 0.400 ENST00000373872.4
 TGIF2
TGFB-induced factor homeobox 2
chr4_-_168155730 0.389 ENST00000502330.1
ENST00000357154.3
 SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr11_+_2466218 0.386 ENST00000155840.5
 KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr11_-_67272794 0.383 ENST00000436757.2
ENST00000356404.3
 PITPNM1

phosphatidylinositol transfer protein, membrane-associated 1

chr17_+_39261584 0.372 ENST00000391415.1
 KRTAP4-9
keratin associated protein 4-9
chr1_-_38273840 0.370 ENST00000373044.2
 YRDC
yrdC N(6)-threonylcarbamoyltransferase domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.9 GO:0038092 nodal signaling pathway(GO:0038092)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.2 0.8 GO:0015692 lead ion transport(GO:0015692)
0.2 0.8 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 0.6 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.6 GO:0008272 sulfate transport(GO:0008272)
0.0 0.6 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.2 0.5 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.5 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 0.4 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.1 0.4 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.4 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.4 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.1 0.3 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.3 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 0.3 GO:0097196 Shu complex(GO:0097196)
0.1 0.3 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.8 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.6 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0045545 syndecan binding(GO:0045545)
0.0 0.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 0.4 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.1 0.4 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 0.4 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.3 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.3 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 0.1 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway