Motif ID: ZNF148

Z-value: 1.385


Transcription factors associated with ZNF148:

Gene SymbolEntrez IDGene Name
ZNF148 ENSG00000163848.14 ZNF148

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF148hg19_v2_chr3_-_125094093_125094198-0.443.3e-02Click!


Activity profile for motif ZNF148.

activity profile for motif ZNF148


Sorted Z-values histogram for motif ZNF148

Sorted Z-values for motif ZNF148



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF148

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_54371114 5.504 ENST00000448420.1
ENST00000439000.1
ENST00000391770.4
ENST00000391771.1
 MYADM



myeloid-associated differentiation marker



chr19_+_41725088 3.826 ENST00000301178.4
 AXL
AXL receptor tyrosine kinase
chr1_-_150208320 3.698 ENST00000534220.1
 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr12_-_58131931 3.337 ENST00000547588.1
 AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr9_+_35673853 3.316 ENST00000378357.4
 CA9
carbonic anhydrase IX
chr10_+_94352956 3.109 ENST00000260731.3
 KIF11
kinesin family member 11
chr4_+_75311019 3.107 ENST00000502307.1
 AREG
amphiregulin
chr4_+_75480629 3.106 ENST00000380846.3
 AREGB
amphiregulin B
chr1_+_150522222 3.104 ENST00000369039.5
 ADAMTSL4
ADAMTS-like 4
chr19_-_19049791 3.059 ENST00000594439.1
ENST00000221222.11
 HOMER3

homer homolog 3 (Drosophila)

chr3_-_52567792 3.043 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
 NT5DC2


5'-nucleotidase domain containing 2


chr10_+_17272608 2.932 ENST00000421459.2
 VIM
vimentin
chr10_+_120967072 2.919 ENST00000392870.2
 GRK5
G protein-coupled receptor kinase 5
chr4_+_75310851 2.887 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr1_+_183155373 2.676 ENST00000493293.1
ENST00000264144.4
 LAMC2

laminin, gamma 2

chrX_-_153599578 2.616 ENST00000360319.4
ENST00000344736.4
 FLNA

filamin A, alpha

chr10_-_25241499 2.587 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
 PRTFDC1


phosphoribosyl transferase domain containing 1


chrX_-_48328631 2.563 ENST00000429543.1
ENST00000317669.5
 SLC38A5

solute carrier family 38, member 5

chrX_-_48328551 2.553 ENST00000376876.3
 SLC38A5
solute carrier family 38, member 5
chr7_+_100770328 2.522 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 198 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 GO:0043486 histone exchange(GO:0043486)
1.9 7.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.7 6.0 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.2 5.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.8 5.3 GO:2000669 positive regulation of pinocytosis(GO:0048549) negative regulation of dendritic cell apoptotic process(GO:2000669)
0.4 5.1 GO:0015816 glycine transport(GO:0015816)
0.5 4.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2 4.9 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.3 4.6 GO:0036066 protein O-linked fucosylation(GO:0036066)
1.2 3.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.6 3.5 GO:0030421 defecation(GO:0030421)
0.2 3.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 3.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 3.2 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.6 2.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 2.9 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.2 2.9 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.9 2.6 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.7 2.6 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.4 2.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 8.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 6.1 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 5.9 GO:0098793 presynapse(GO:0098793)
0.0 5.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 4.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 4.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.0 GO:0005882 intermediate filament(GO:0005882)
0.2 3.5 GO:0033643 host cell part(GO:0033643)
0.1 3.3 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 3.2 GO:0005876 spindle microtubule(GO:0005876)
0.1 2.9 GO:0036020 endolysosome membrane(GO:0036020)
0.0 2.9 GO:0045178 basal part of cell(GO:0045178)
0.1 2.8 GO:0031528 microvillus membrane(GO:0031528)
0.9 2.7 GO:0005607 laminin-2 complex(GO:0005607)
0.9 2.6 GO:0031523 Myb complex(GO:0031523)
0.9 2.6 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.1 2.6 GO:0042627 chylomicron(GO:0042627)
0.0 2.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.1 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 GO:0005096 GTPase activator activity(GO:0005096)
0.1 8.7 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.1 6.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 5.5 GO:0008083 growth factor activity(GO:0008083)
0.3 5.3 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 5.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.5 5.1 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 5.0 GO:0045296 cadherin binding(GO:0045296)
1.2 3.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.5 3.5 GO:1990254 keratin filament binding(GO:1990254)
0.2 3.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 3.1 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 3.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 3.1 GO:0050699 WW domain binding(GO:0050699)
1.0 2.9 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.1 2.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 2.8 GO:0045499 chemorepellent activity(GO:0045499)
0.7 2.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.3 2.6 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 2.6 GO:0038132 neuregulin binding(GO:0038132)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.5 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.2 5.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.2 5.3 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 5.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 4.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 4.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 2.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 1.7 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 1.5 PID_NECTIN_PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 4.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 3.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 3.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 3.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 3.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 2.8 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 2.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 2.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 2.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 2.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.8 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.5 REACTOME_KINESINS Genes involved in Kinesins