Motif ID: ZNF263

Z-value: 1.653


Transcription factors associated with ZNF263:

Gene SymbolEntrez IDGene Name
ZNF263 ENSG00000006194.6 ZNF263

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF263hg19_v2_chr16_+_3313791_3313834-0.116.0e-01Click!


Activity profile for motif ZNF263.

activity profile for motif ZNF263


Sorted Z-values histogram for motif ZNF263

Sorted Z-values for motif ZNF263



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF263

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_51504852 12.617 ENST00000391806.2
ENST00000347619.4
ENST00000291726.7
ENST00000320838.5
 KLK8



kallikrein-related peptidase 8



chr19_-_51466681 10.404 ENST00000456750.2
 KLK6
kallikrein-related peptidase 6
chr1_+_150480576 8.555 ENST00000346569.6
 ECM1
extracellular matrix protein 1
chr1_+_150480551 8.005 ENST00000369049.4
ENST00000369047.4
 ECM1

extracellular matrix protein 1

chr19_-_51487071 7.694 ENST00000391807.1
ENST00000593904.1
 KLK7

kallikrein-related peptidase 7

chr19_-_55658687 7.218 ENST00000593046.1
 TNNT1
troponin T type 1 (skeletal, slow)
chr19_-_51456198 6.757 ENST00000594846.1
 KLK5
kallikrein-related peptidase 5
chr17_+_70117153 5.857 ENST00000245479.2
 SOX9
SRY (sex determining region Y)-box 9
chr6_-_30654977 5.820 ENST00000399199.3
 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr19_-_51472031 5.168 ENST00000391808.1
 KLK6
kallikrein-related peptidase 6
chr19_-_55658281 4.648 ENST00000585321.2
ENST00000587465.2
 TNNT1

troponin T type 1 (skeletal, slow)

chr1_+_17531614 4.462 ENST00000375471.4
 PADI1
peptidyl arginine deiminase, type I
chr22_-_37640456 4.198 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
 RAC2


ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)


chr8_+_22022800 4.031 ENST00000397814.3
 BMP1
bone morphogenetic protein 1
chr22_-_37640277 3.996 ENST00000401529.3
ENST00000249071.6
 RAC2

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

chr19_+_11200038 3.743 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
 LDLR





low density lipoprotein receptor





chr12_-_54813229 3.662 ENST00000293379.4
 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr12_-_25055949 3.617 ENST00000539282.1
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr6_+_151561506 3.570 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr1_+_20915409 3.542 ENST00000375071.3
 CDA
cytidine deaminase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 440 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 17.8 GO:0016540 protein autoprocessing(GO:0016540)
0.7 16.6 GO:0030502 negative regulation of bone mineralization(GO:0030502)
2.4 14.5 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
1.6 14.5 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
1.6 12.6 GO:0031642 negative regulation of myelination(GO:0031642)
0.9 9.9 GO:0034465 response to carbon monoxide(GO:0034465)
1.6 9.5 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.8 8.4 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.2 6.5 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.1 6.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
1.1 6.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 6.4 GO:0030574 collagen catabolic process(GO:0030574)
2.0 5.9 GO:0060516 primary prostatic bud elongation(GO:0060516) renal vesicle induction(GO:0072034)
0.9 5.4 GO:0032252 secretory granule localization(GO:0032252) endoplasmic reticulum localization(GO:0051643)
0.1 5.4 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 4.9 GO:1901998 toxin transport(GO:1901998)
0.8 4.7 GO:0055064 chloride ion homeostasis(GO:0055064)
0.3 4.7 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.7 4.6 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.9 4.5 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 15.2 GO:0005861 troponin complex(GO:0005861)
2.1 14.5 GO:0097209 epidermal lamellar body(GO:0097209)
0.1 14.0 GO:0005901 caveola(GO:0005901)
0.8 13.7 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 11.5 GO:0005730 nucleolus(GO:0005730)
0.0 10.9 GO:0005925 focal adhesion(GO:0005925)
0.0 8.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.1 7.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 6.6 GO:0044798 nuclear transcription factor complex(GO:0044798)
2.1 6.2 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.2 5.9 GO:0031528 microvillus membrane(GO:0031528)
0.0 5.9 GO:0000790 nuclear chromatin(GO:0000790)
0.9 5.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.6 5.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 5.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.6 5.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.3 4.9 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.4 GO:0005796 Golgi lumen(GO:0005796)
0.3 4.3 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 282 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 51.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.3 18.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
1.2 16.4 GO:0031014 troponin T binding(GO:0031014)
1.2 9.9 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
1.6 9.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 7.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 7.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 6.9 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.4 6.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 6.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.1 6.4 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.6 6.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.2 5.8 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 5.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 5.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 5.2 GO:0019902 phosphatase binding(GO:0019902)
1.0 5.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1 5.0 GO:0005518 collagen binding(GO:0005518)
0.2 4.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 4.6 GO:0019887 protein kinase regulator activity(GO:0019887)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 17.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 14.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 13.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 10.3 NABA_COLLAGENS Genes encoding collagen proteins
0.6 8.7 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 6.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.2 6.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.2 6.1 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 6.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 5.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 5.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 5.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 5.1 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 4.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.2 2.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 12.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.4 10.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 9.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.5 9.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.5 8.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 7.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 6.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.3 5.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 4.6 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 4.5 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 4.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 4.4 REACTOME_CELL_JUNCTION_ORGANIZATION Genes involved in Cell junction organization
0.1 4.3 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.2 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.1 4.0 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.2 3.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 3.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 3.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.1 3.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions