Motif ID: ZNF423

Z-value: 0.959


Transcription factors associated with ZNF423:

Gene SymbolEntrez IDGene Name
ZNF423 ENSG00000102935.7 ZNF423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49698136_496982090.414.6e-02Click!


Activity profile for motif ZNF423.

activity profile for motif ZNF423


Sorted Z-values histogram for motif ZNF423

Sorted Z-values for motif ZNF423



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_22022800 3.292 ENST00000397814.3
 BMP1
bone morphogenetic protein 1
chr5_+_150400124 3.235 ENST00000388825.4
ENST00000521650.1
ENST00000517973.1
 GPX3


glutathione peroxidase 3 (plasma)


chr6_+_151186554 2.507 ENST00000367321.3
ENST00000367307.4
 MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

chr19_-_11689752 2.363 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
 ACP5



acid phosphatase 5, tartrate resistant



chr1_-_204121013 2.289 ENST00000367201.3
 ETNK2
ethanolamine kinase 2
chr10_-_121296045 2.285 ENST00000392865.1
 RGS10
regulator of G-protein signaling 10
chr1_-_204121102 2.277 ENST00000367202.4
 ETNK2
ethanolamine kinase 2
chr1_-_204121298 2.231 ENST00000367199.2
 ETNK2
ethanolamine kinase 2
chr11_-_61062762 2.201 ENST00000335613.5
 VWCE
von Willebrand factor C and EGF domains
chr8_+_22022223 2.161 ENST00000306385.5
 BMP1
bone morphogenetic protein 1
chr17_+_6347729 1.864 ENST00000572447.1
 FAM64A
family with sequence similarity 64, member A
chr5_+_135385202 1.848 ENST00000514554.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr17_+_6347761 1.840 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A




family with sequence similarity 64, member A




chr8_+_22022653 1.839 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
 BMP1


bone morphogenetic protein 1


chr16_+_71392616 1.831 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
 CALB2


calbindin 2


chr12_-_125348329 1.800 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
 SCARB1




scavenger receptor class B, member 1




chr9_-_131486367 1.748 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
 ZDHHC12




zinc finger, DHHC-type containing 12




chrX_-_51239425 1.667 ENST00000375992.3
 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr22_-_37823468 1.660 ENST00000402918.2
 ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr12_-_125348448 1.617 ENST00000339570.5
 SCARB1
scavenger receptor class B, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.6 GO:0001502 cartilage condensation(GO:0001502)
0.3 6.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.9 3.7 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
1.1 3.4 GO:0015920 lipopolysaccharide transport(GO:0015920)
0.5 3.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 3.0 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.5 2.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 2.4 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 2.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 2.3 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 2.2 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.3 1.7 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 1.7 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 1.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.6 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.1 1.5 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 1.4 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 1.3 GO:0060346 bone trabecula formation(GO:0060346)
0.0 1.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.4 GO:0031528 microvillus membrane(GO:0031528)
0.0 3.2 GO:0043679 axon terminus(GO:0043679)
0.0 1.8 GO:0005921 gap junction(GO:0005921)
0.0 1.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.2 1.6 GO:0098845 postsynaptic endosome(GO:0098845)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 1.3 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.2 1.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.9 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 0.6 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.3 GO:0046930 pore complex(GO:0046930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 6.8 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.9 3.7 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
1.1 3.4 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.3 3.2 GO:0008430 selenium binding(GO:0008430)
0.0 2.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 2.4 GO:0043426 MRF binding(GO:0043426)
0.2 2.4 GO:0008199 ferric iron binding(GO:0008199)
0.1 2.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.2 GO:0017166 vinculin binding(GO:0017166)
0.0 2.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 2.0 GO:0043130 ubiquitin binding(GO:0043130)
0.1 1.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 1.7 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.2 1.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 1.5 GO:1990254 keratin filament binding(GO:1990254)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 1.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2 1.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 1.2 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 PID_P73PATHWAY p73 transcription factor network
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 0.9 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 0.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 10.7 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 6.8 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 2.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.2 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.8 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 1.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.5 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 1.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 1.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 0.9 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 0.6 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.6 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling